Preface |
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vii | |
About the Authors |
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viii | |
About the National Pharmacy Technician Association |
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ix | |
Acknowledgments |
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x | |
Contributors |
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xi | |
Reviewers |
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xii | |
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chapter 1 Introduction to Sterile Products |
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1 | (10) |
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1 | (1) |
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Parenteral Routes of Administration |
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2 | (1) |
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3 | (1) |
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4 | (1) |
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Sterile Products: Terminology and Abbreviations |
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4 | (7) |
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8 | (1) |
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8 | (1) |
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8 | (1) |
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8 | (3) |
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chapter 2 USP 797 Guidelines: Compounding Areas and Equipment |
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11 | (19) |
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11 | (4) |
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USP <797> Guidebook to Pharmaceutical Compounding---Sterile Preparations |
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12 | (1) |
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Facilities and Clean Room |
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13 | (1) |
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14 | (1) |
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14 | (1) |
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Primary Engineering Controls |
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15 | (4) |
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19 | (1) |
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19 | (1) |
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Personal Protection Equipment |
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19 | (1) |
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20 | (10) |
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21 | (1) |
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21 | (1) |
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21 | (2) |
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23 | (4) |
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27 | (1) |
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27 | (1) |
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27 | (1) |
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27 | (3) |
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chapter 3 Aseptic Calculations |
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30 | (23) |
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30 | (1) |
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Intravenous Additive Dosage Calculations |
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31 | (2) |
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Diluent, Powder, and Final Volume of Reconstituted Powder Vials |
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33 | (3) |
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36 | (1) |
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36 | (1) |
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Intravenous Frequency or Schedule |
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37 | (1) |
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37 | (2) |
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Percentage Concentrations |
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39 | (3) |
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42 | (4) |
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Electrolytes Added to Total Parenteral Nutrition Preparations |
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46 | (2) |
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48 | (5) |
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48 | (1) |
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48 | (5) |
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chapter 4 Properties of Sterile Products |
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53 | (7) |
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53 | (1) |
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54 | (1) |
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54 | (1) |
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54 | (1) |
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Compatibility and Stability |
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55 | (1) |
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56 | (1) |
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Osmolality and Osmolarity |
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56 | (4) |
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57 | (1) |
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57 | (1) |
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57 | (3) |
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chapter 5 Aseptic Technique |
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60 | (19) |
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60 | (1) |
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61 | (1) |
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61 | (1) |
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61 | (1) |
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62 | (12) |
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63 | (4) |
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67 | (5) |
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Preparing a Sterile Dosage Form |
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72 | (2) |
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Additional Aseptic Procedures |
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74 | (5) |
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75 | (1) |
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75 | (1) |
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76 | (1) |
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76 | (3) |
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chapter 6 Sterile Product Preparations |
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79 | (10) |
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79 | (1) |
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80 | (2) |
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80 | (1) |
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81 | (1) |
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82 | (1) |
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82 | (1) |
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Patient-Controlled Analgesia |
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83 | (1) |
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83 | (1) |
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Neonates and Pediatric Patients |
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83 | (1) |
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84 | (1) |
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84 | (1) |
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Total Parenteral Nutrition |
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84 | (1) |
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84 | (2) |
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84 | (1) |
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85 | (1) |
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85 | (1) |
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85 | (1) |
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86 | (1) |
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86 | (3) |
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87 | (1) |
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87 | (1) |
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87 | (2) |
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chapter 7 Total Parenteral Nutrition |
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89 | (10) |
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89 | (1) |
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90 | (1) |
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90 | (1) |
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Calories and Carbohydrates |
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90 | (1) |
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91 | (1) |
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Electrolytes and Minerals |
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91 | (1) |
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91 | (2) |
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Compounding the Total Parenteral Nutrition |
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93 | (2) |
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95 | (4) |
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95 | (1) |
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95 | (1) |
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96 | (1) |
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96 | (1) |
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96 | (1) |
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96 | (3) |
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99 | (19) |
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99 | (2) |
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101 | (1) |
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Compounding Chemotherapy Medications |
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102 | (9) |
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102 | (6) |
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108 | (1) |
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109 | (2) |
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Procedures for Handling Sterile Injectable Hazardous Drugs |
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111 | (1) |
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112 | (1) |
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Disposal of Cytotoxic Medications |
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113 | (1) |
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113 | (1) |
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ASHP Guidelines for Safe Handling of Cytotoxic Drugs |
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114 | (1) |
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115 | (3) |
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115 | (1) |
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115 | (1) |
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116 | (2) |
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chapter 9 Quality Control and Assurance |
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118 | (16) |
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118 | (1) |
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Elements of Quality in Pharmacy |
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119 | (1) |
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119 | (1) |
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Quality Assurance Functions |
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119 | (1) |
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119 | (1) |
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120 | (1) |
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Food and Drug Administration |
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120 | (1) |
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120 | (1) |
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Centers for Disease Control and Prevention |
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120 | (1) |
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American Society of Health-System Pharmacists |
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120 | (1) |
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United States Pharmacopeia |
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121 | (1) |
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121 | (1) |
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ASHP Guidelines on Quality Assurance for Pharmacy-Prepared Sterile Products |
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121 | (5) |
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121 | (2) |
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123 | (2) |
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125 | (1) |
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United States Pharmacopeia 797 |
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126 | (5) |
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127 | (1) |
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Low-Risk-Level Compounded Sterile Products |
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127 | (1) |
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Medium-Risk-Level Compounded Sterile Products |
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128 | (1) |
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High-Risk-Level Compounded Sterile Products |
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128 | (1) |
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Environmental Sampling Testing |
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129 | (1) |
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Cleaning and Disinfecting the Compounding Area |
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129 | (1) |
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130 | (1) |
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Personnel, Education, and Evaluation |
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130 | (1) |
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Storage and Handling inside and outside the Pharmacy |
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130 | (1) |
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130 | (1) |
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Aseptic Technique, Product Preparation, and Garb |
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130 | (1) |
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130 | (1) |
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131 | (1) |
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Documentation and Labeling |
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131 | (3) |
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132 | (1) |
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132 | (1) |
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132 | (2) |
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Appendix A Terminology and Abbreviations |
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134 | (3) |
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Appendix B Common Intravenous Medications |
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137 | (3) |
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Appendix C Training and Validation Forms |
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140 | (20) |
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Appendix D Instructions for Left-Handed Personnel |
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160 | (6) |
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Appendix E Institutional Intravenous Certification Test |
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166 | (7) |
Index |
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173 | |