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Stress Response in Pathogenic Bacteria [Kõva köide]

Contributions by (The University of Birmingham, UK), Contributions by (The University of Manchester, UK), Contributions by (Umeå), Edited by (The University of Adelaide, Australia), Contributions by (Washington University School of Medicine, USA), Contributions by , Contributions by , Contributions by (University of Massachusetts, USA), Contributions by , Contributions by (Washington University, USA)
The ability of pathogenic bacteria to adapt to various chemical, biochemical and physical conditions within the human host and their ability to respond to stresses generated in these environments is a central feature of infectious diseases and the outcome of bacterial infection. This book covers the key aspects of this rapidly developing field, including the generation of stresses by the host immune system, bacterial response to reactive chemicals, and adaptation to environmental conditions of anatomical niches such as the gut, mouth and urogenital tract. It also addresses the increasing importance of different metal ions in the pathogenesis and survival of specific bacteria. With chapters by active research experts in the field, the book provides a comprehensive outline of the current understanding of this field, the latest developments and where future research is likely to be directed.
Contributors vii
Preface ix
PART 1 Oxidative and Nitrosative Stress
1 Oxidative and Nitrosative Stress Defence Systems in Escherichia coli and Pseudomonas aeruginosa: A Model Organism of Study Versus a Human Opportunistic Pathogen
3(30)
James A. Imlay
Daniel J. Hassett
2 Coordinated Regulation of Stress and Virulence Adaptations in Stages of Haemophilus Pathogenesis
33(15)
Sandy M.S. Wong
Brian J. Akerley
3 Nitric Oxide Stress in Escherichia coli and Salmonella
48(20)
Stephen Spiro
4 Nitric Oxide and Gram-positive Pathogens: Host Triggers and Bacterial Defence Mechanisms
68(25)
Glen Ulett
Adam Potter
PART 2 Novel Gene Regulation in Response to Host Defences
5 Novel Regulation in Response to Host-generated Stresses: The MerR Family of Regulators in Pathogenic Bacteria
93(22)
Stephen P. Kidd
6 Stress Responses in the Pathogenic Neisseria: Overlapping Regulons and sRNA Regulation
115(20)
Stuart A. Hill
PART 3 Acid Stress, pH Control and Survival in the Human Host
7 Acid Survival Mechanisms of Bacterial Pathogens of the Digestive Tract
135(32)
Hanan Gancz
D. Scott Merrell
8 Urease and the Bacterial Acid Stress Response
167(18)
Peter T. Olivers
PART 4 Nutrient Stress
9 Secretion Systems and Metabolism in the Pathogenic Yersiniae
185(36)
Matthew S. Francis
10 Response of Neisseria gonorrhoeae to Oxygen Limitation and Excess
221(24)
Jeffery A. Cole
PART 5 Metal Ions and Pathogenic Bacteria
11 Copper and Zinc Stress in Bacteria
245(21)
Selina R. Clayton
Karin Heurlier
Taku Oshima
Jon L. Hobman
12 Metal Ion Sensing in Mycobacterium tuberculosis
266(17)
Jennifer S. Cavet
13 Salmonella and the Host in the Battle for Iron
283(14)
Elisa Deriu
Janet Z. Liu
Manuela Raffatellu
Index 297
Dr Stephen Kidd was awarded his PhD in Molecular Microbiology from the University of Queensland. He then worked in Prof. Nigel Brown's research group (The University of Birmingham, UK) on the transcription factor MerR; the mechanism of its environmental stress response. He started work on a number of other MerR-like regulators and then after moving back to the University of Queensland, some of these which functioned in disulfide stress response in pathogenic bacteria. In November 2008 he started working at the University of Adelaide as a Group Leader in Microbiology and Immunology.