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Studies on Renal Disorders Softcover reprint of the original 1st ed. 2011Suurem pilt
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Conditions such as oxidative stress and hypoxia have been implicated in the genesis of kidney disease. This book collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances.

Conditions such as oxidative stress and hypoxia, which have a generalized impact on the oxygen metabolism, have been implicated in the genesis of kidney disease. This means that deepening our understanding of the pathobiology of oxygen metabolism in such diseases could be a fruitful path towards tangible clinical benefits. Studies in Renal Disorder collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances.The causal role of impaired oxygen metabolism in kidney disease has numerous clinical implications. It affects our understanding of the therapeutic benefits accruing from anti-hypertensive agents; the way we control hyperglycemia/hyperinsulinemia and hyperlipidemia; and our use of dietary approaches to the correction of obesity. The defensive mechanisms against oxidative stress, such as the Nrf2-Keap1 system, and hypoxia, such as the PHD-HIF system, have recently been explored in various cells, including kidney cells. These mechanisms include intracellular sensors for oxidative stress and hypoxia. This means that novel approaches targeting these sensors may offer clinical benefits in kidney disease in which oxidative stress and/or hypoxia is a final, common pathway.

Conditions such as oxidative stress and hypoxia have been implicated in the genesis of kidney disease. This book collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances.

Arvustused

From the reviews:

This book is a collection of reviews on derangements of oxygen metabolism in kidney diseases. addressed to students (mostly postgraduate), researchers, and academic clinicians . I liked the organization of each chapter with an abstract, key words, introduction, and conclusion as well as extensive, up-to-date, relevant references. This is the only book that I am aware of that is an extensive, updated review of abnormal oxygen metabolism in a large number of pathologic renal diseases. (Mony Fraer, Doodys Review Service, July, 2011)

Preface.
Chapter
1. Oxidative stress injury in glomerular mesangium .-
Chapter
2. Transition Metals and other Forms of Oxidative Protein Damage in
.- Renal Disease.
Chapter
3. Cyclo-oxygenase in the kidney and oxidative
stress .
Chapter
4. Renin angiotensin system in the kidney and oxidative
stress -Local Renin-Angiotensin-Aldosterone-System and NAD(P)H
oxidase-dependent oxidative stress in the kidney- .
Chapter
5. Thiamine in
diabetic renal disease dietary insufficiency, renal.- washout, anti-stress
gene response, therapeutic supplements, risk predictor and link to genetic
susceptibility.
Chapter
6. Novel members of the globin family and their
function against oxidative stress .- Clinical Aspects of Oxidative Stress in
the Kidney.
Chapter
7. Hypertension .
Chapter
8. Uric acid and oxidative
stress .
Chapter
9. Reactive oxygen and nitrogen species, oxidative and
nitrosative .- stress and their role in the pathogenesis of acute kidney
injury.
Chapter
10. Oxidative stress in the kidney: proximal tubule
disorders .
Chapter
11. Iron metabolism and oxidative stress .
Chapter
12.
Hypoxia, oxidative stress and the pathophysiology of contrast-media-induced
nephropathy .
Chapter
13. Cardiovascular complications in renal failure:
implications of advanced glycation end-products and their receptor, RAGE .-
Chapter
14. Infection and the kidney .
Chapter
15. Oxidative/carbonyl stress
in the renal circulation and cardiovascular renal injury .- .- Current
Therapy Targeting Oxidative Stress.
Chapter
16. Renin angiotensin system .-
Chapter
17. Oxidative stress in kidney injury-peroxisome
proliferator-activated receptor- agonists are in control.
Chapter
18.
Statin .
Chapter
19. N-acetylcysteine in kidney disease .
Chapter
20.
Advanced glycation end products (AGEs) inhibitor .- Section
2. Hypoxia.-
Hypoxia Biology.
Chapter
21. Involvement of hypoxia-inducible factor 1 in
physiological and pathological responses to continuous and
intermittenthypoxia: Role of reactive oxygen species .
Chapter
22.
Regulation of oxygen homeostasis by PHDs .
Chapter
23. Oxygen-dependent
regulation of erythropoiesis .
Chapter
24. Intricate link between hypoxia
and oxidative stress in chronic kidney disease .
Chapter
25. RNA
interference and the regulation of renal gene expression in .- hypoxia.-
Hypoxia Pathology in Renal Disorders.
Chapter 26.Cardio-renal connection:
The role of hypoxia and oxidative stress .
Chapter
27. HIF in acute kidney
injury from pathophysiology to a novel approach of organ protection .-
Chapter
28. Hypoxia in chronic kidney disease: the final common pathway to
end stage renal disease .
Chapter
29. Oxidative stress and hypoxia in the
pathogenesis of diabetic.- nephropathy .
Chapter
30. Estimation of kidney
oxygenation by BOLD-MRI .
Chapter
31. Anemia and progression of chronic
kidney disease.- Section
3. Novel therapeutic approaches against oxidative
stress and hypoxia.
Chapter
32. Novel therapeutic approaches against hypoxia
and oxidative stress,targeting intracellular sensor molecules for oxygen and
oxidative stress .
Chapter
33. Endoplasmic reticulum (ER) stress as a target
of therapy against oxidative stress and hypoxia .
Chapter
34. Stem cell
therapy against oxidative stress and hypoxia.