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Supercritical Fluid Chromatography [Pehme köide]

Edited by (Department of Chemistry, Wayne State University, Detroit, MI, USA)
  • Formaat: Paperback / softback, 572 pages, kõrgus x laius: 229x152 mm, kaal: 910 g
  • Sari: Handbooks in Separation Science
  • Ilmumisaeg: 20-Feb-2017
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128092076
  • ISBN-13: 9780128092071
Teised raamatud teemal:
Supercritical Fluid ChromatographySuurem pilt
  • Formaat: Paperback / softback, 572 pages, kõrgus x laius: 229x152 mm, kaal: 910 g
  • Sari: Handbooks in Separation Science
  • Ilmumisaeg: 20-Feb-2017
  • Kirjastus: Elsevier Science Publishing Co Inc
  • ISBN-10: 0128092076
  • ISBN-13: 9780128092071
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9780128092071.html
Märksõnad:

Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in supercritical fluid chromatography (SFC) and how it should be implemented in laboratory science. Supercritical fluid chromatography is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in supercritical fluid chromatography in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and underappreciated.

Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique, introducing SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at a more advanced level than is currently used in many laboratories.

  • Edited and authored by world-leading chromatography experts
  • Provides comprehensive coverage of SFC in a single volume
  • Contains extensive referencing that facilitates identification of key research developments
  • Presents more than 200 figures and tables to aid in the retention of key concepts

Muu info

Defines the concept of contemporary practice in supercritical fluid chromatography and how it should be implemented in laboratory science
List of Contributors
xi
Handbooks in Separation Science Series xiii
1 Milestones in Supercritical Fluid Chromatography: A Historical View of the Modernization and Development of Supercritical Fluid Chromatography
1(22)
R. Mcclain
1.1 Introduction
2(1)
1.2 The 1960s
2(2)
1.3 The 1970s
4(2)
1.4 The 1980s
6(3)
1.5 The 1990s
9(4)
1.6 The 2000s
13(2)
1.7 The 2010s
15(5)
1.8 Conclusion
20(3)
References
20(3)
2 Theory of Supercritical Fluid Chromatography
23(34)
D.P. Poe
2.1 Introduction
24(1)
2.2 The Mobile Phase in SFC
24(8)
2.3 Fluid Compressibility and Average Parameters in Nonuniform Columns
32(2)
2.4 Retention in SFC
34(3)
2.5 Kinetic Theory
37(12)
2.6 Kinetic Theory and Contemporary Practice
49(3)
2.7 Conclusions
52(5)
Acknowledgments
52(1)
References
52(5)
3 Practical Approaches to Column Selection for Supercritical Fluid Chromatography
57(46)
W.P. Farrell
3.1 Introduction
58(2)
3.2 Key Parameters Governing SFC Separations
60(16)
3.3 Stationary Phases
76(13)
3.4 New Stationary Phases and Their Potential Impact on SFC
89(6)
3.5 Conclusion
95(8)
Acknowledgments
96(1)
References
96(7)
4 Column Characterization
103(24)
C. West
4.1 Introduction
103(1)
4.2 Nonchromatographic Methods
104(1)
4.3 Stability of Stationary Phases
105(1)
4.4 Column Efficiency
106(1)
4.5 Probe Analytes
107(4)
4.6 Quantitative Structure---Retention Relationships
111(10)
4.7 Conclusion
121(6)
References
121(6)
5 Method Development in Supercritical Fluid Chromatography
127(26)
M. Ashraf-Khorassani
M. Combs
5.1 Introduction
128(1)
5.2 Sample Type
129(2)
5.3 Detectors
131(1)
5.4 Columns
132(12)
5.5 Mobile Phase for pSFC
144(1)
5.6 Additives
145(2)
5.7 Density
147(1)
5.8 Method Development in Practice
148(1)
5.9 Conclusion
149(4)
References
149(4)
6 Application of Multiple Column Supercritical Fluid Chromatography
153(20)
C. Wang
A.A. Tymiak
Y. Zhang
6.1 Introduction
154(1)
6.2 Applications of SFC in Two-Dimensional Chromatography
155(5)
6.3 Tandem Column SFC
160(4)
6.4 Method Development in Tandem Column SFC
164(2)
6.5 The Role of Pressure in Tandem Column SFC
166(4)
6.6 Conclusion
170(3)
References
170(3)
7 Evolution of Instrumentation for Analytical Scale Supercritical Fluid Chromatography
173(40)
T.A. Berger
7.1 Introduction
174(11)
7.2 Pumping CO2
185(7)
7.3 Pump Drives
192(8)
7.4 Pump Head Chillers
200(2)
7.5 Mixers
202(2)
7.6 Autosamplers
204(1)
7.7 Oven/Column Compartment
205(1)
7.8 UV--Vis Detectors
206(3)
7.9 Back Pressure Regulators
209(2)
7.10 Miscellaneous
211(2)
References
212(1)
8 Hyphenated Detectors: Mass Spectrometry
213(32)
V. Desfontaine
J.-L. Veuthey
D. Guillarme
8.1 Introduction
214(1)
8.2 Ionization Sources for SFC-MS Operation
215(4)
8.3 Available Interfaces for SFC-MS Hyphenation
219(7)
8.4 Mass Analyzers for SFC-MS Operation
226(3)
8.5 Performance Comparison Between LC-ESI/MS and SFC-ESI/MS
229(4)
8.6 Applications of SFC-MS
233(5)
8.7 Conclusion
238(7)
References
238(7)
9 Theories for Preparative SFC
245(30)
A. Tarafder
9.1 Introduction
245(3)
9.2 Factors Influencing Preparative SFC Performance
248(3)
9.3 Designing a Preparative SFC Method
251(21)
9.4 Conclusion
272(3)
References
273(2)
10 Practical Aspects and Applications of Preparative Supercritical Fluid Chromatography
275(42)
E.R. Francotte
10.1 Introduction
276(1)
10.2 Short History of Preparative SFC
277(1)
10.3 General Considerations
278(6)
10.4 Preparative Chiral Separation on Packed Column SFC
284(9)
10.5 Preparative-Scale Achiral SFC Purifications on Packed Columns
293(9)
10.6 High-Throughput Achiral SFC Purifications
302(2)
10.7 Preparative SFC by Simulated Moving Bed Chromatography (SMB)
304(1)
10.8 Large Scale and Industrial Applications
304(1)
10.9 Conclusion
305(12)
References
306(11)
11 Validation of Supercritical Fluid Chromatography Methods
317(28)
A. Dispas
P. Lebrun
P. Hubert
11.1 Introduction
318(1)
11.2 Validation Criteria
319(3)
11.3 Total Error Approach
322(4)
11.4 Robust Optimization Strategy
326(2)
11.5 Method Transfer
328(1)
11.6 SFC Methods Validation
328(13)
11.7 Conclusion
341(4)
References
341(4)
12 Separation of Stereoisomers
345(36)
C.M. Galea
Y. Vander Heyden
D. Mangelings
12.1 Introduction
346(1)
12.2 Stereoisomerism
347(1)
12.3 Separations of Enantiomers
348(2)
12.4 Chiral Stationary Phases
350(8)
12.5 Chromatographic Parameters in Chiral SFC
358(3)
12.6 Comparison to Other Techniques
361(2)
12.7 Recent Developments in Stereoselective SFC
363(3)
12.8 Overview of SFC Stereoisomeric Applications
366(1)
12.9 Separation of Diastereomers
366(6)
12.10 Conclusion
372(9)
References
373(8)
13 Supercritical Fluid Chromatography of Petroleum Products
381(38)
D. Thiebaut
13.1 Introduction
382(2)
13.2 Technical Part: The Coupling and Use of Supercritical Fluid Chromatography-Flame-Ionization Detector
384(3)
13.3 Simulated Distillation
387(6)
13.4 Group-Type Analysis in Supercritical Fluid Chromatography and Related Applications
393(14)
13.5 Separation of Base Stocks and Lubricant Additives
407(4)
13.6 Conclusion---Perspectives
411(8)
Acknowledgments
412(1)
References
413(6)
14 Separation of Lipids
419(20)
T. Yamada
K. Taguchi
T. Bamba
14.1 Introduction
420(2)
14.2 SFC-MS Methods for Various Lipid Classes
422(12)
14.3 Online SFE-SFC-MS Methods for Lipid Profiling
434(3)
14.4 Application of SFC-MS Methods in Life Science
437(1)
14.5 Conclusion and Future Perspectives
437(2)
References
437(2)
15 Separation of Natural Products
439(22)
M. Ganzera
A. Murauer
15.1 Introduction
439(1)
15.2 Selected Applications
440(21)
Conclusion
456(1)
References
457(4)
16 Pharmaceutical Applications
461(34)
L. Novakova
K. Plachka
16.1 Introduction
462(6)
16.2 SFC in Drug Discovery
468(4)
16.3 SFC in Analysis of Drug Substances and Drug Products
472(11)
16.4 SFC in Analysis of Drugs and Their Metabolites in Biological Fluids
483(5)
16.5 Conclusion
488(7)
References
489(6)
17 Applications to Food Analysis
495(20)
J. Bernal
A.M. Ares
L. Toribio
17.1 Introduction
495(3)
17.2 Food of Animal Origin and Related Products
498(2)
17.3 Food of Plant Origin and Related Products
500(9)
17.4 Other Origins
509(3)
17.5 Conclusion
512(3)
References
512(3)
18 Physicochemical Property Measurements Using SFC Instrumentation
515(26)
T.L. Chester
18.1 Introduction
516(1)
18.2 A Simple Example: Viscosity Estimation
516(2)
18.3 Determination of Phase Behavior
518(11)
18.4 Direct Solubility Estimation
529(1)
18.5 Adsorption Isotherm Determinations
530(2)
18.6 Diffusion
532(1)
18.7 Limitations of Estimates
533(3)
18.8 Conclusion
536(5)
References
536(5)
Index 541
Colin F. Poole was born and educated in the United Kingdom receiving a B.Sc. in Chemistry from the University of Leeds (1971) followed by graduate studies at the University of Bristol, MSc. in analytical chemistry (1972), and Ph.D. with Prof. E. D. Morgan at the University of Keele (1975) on the analysis of insect moulting hormones. Since 1980 he has been at the Department of Chemistry, Wayne State University, Detroit, Michigan, USA , except for 1995-1996, spent as the Governors Lecturer and Professor of Analytical Chemistry at Imperial College of Science, Technology & Medicine, London, in the United Kingdom. He is a former Science Advisor to the US Food and Drug Administration, a position he occupied for 25 years. Professor Poole has broad interests in the separation and detection of small molecules in biological, environmental, and food samples using a range of sample preparation, chromatographic and data analysis tools. He is the co-author of over 400 papers, 20 books, an editor of Journal of Chromatography A and a member of the editorial boards of 5 other analytical chemistry journals. .