Synthetic Polymers in Drug and Biotherapeutics Delivery covers recent advances in the design, synthesis and application of engineered polymers in the delivery of drugs and other biotherapeutic agents. The book covers new polymers that are fast replacing obsolete polymers in the field of drug delivery. Each chapter focuses on a specific polymer, detailing its design, synthesis, fabrication techniques and applications in drug and biotherapeutics delivery. This thorough examination provides a review of the latest research in this rapidly-changing field. Hence, it will be of interest to materials scientists, pharmaceutical scientists, biomedical engineers, chemical engineers and clinicians with an interest in materials development. Synthetic polymers provide a unique set of opportunities in drug and bio-therapeutic delivery due to their chemical versatility and tunable physicochemical properties. Such polymers can be formulated into nanoparticles, nanofibers, nanogels, microparticles, beads, hydrogels, and scaffolds to suit specific needs such as drug release rate and biodegradation with low toxicity.
- Details the immunological aspects of synthetic polymeric materials, helping the reader prepare for, and even avoid, unwanted side effects of use
- Reviews each polymer sub-type, chapter-by-chapter, ensuring thorough coverage and detailed analysis of each
- Explores a range of applications in drug and biotherapeutics delivery, including treatments for cardiovascular, neurological and gastrointestinal diseases
1. Role and challenges of synthetic biopolymers in drug/bio-therapeutics delivery
2. Poly (caprolactone)
3. Poly (d,l lactide-co-glycolide)
4. Poly (amidoamines)
5. Poly (vinyl alcohol)
6. Poly (oxozolines)
7. Poly (amides)
8. Poly (ethylenimine)
9. Poly (ethylene oxide)
10. Poly (N-isopropyl acrylamide)
11. Poly (2- hydroxyethyl methacrylate)
12. Poly (N-(2-hydroxypropyl methacrylamide)
13. Poly (dioxanone)
14. Poly (phosphazenes)
15. Blending techniques and formulation strategies
16. Clinical application, regulatory status, and future perspective of synthetic biopolymers in drug/bio-therapeutics delivery
Rangasamy Jayakumar is a Professor at the Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (Deemed University), Kerala, India. He received his PhD degree in polymer chemistry from Anna University, Chennai, India (2002) and MSc degree from Bharathidasan University.
Már Másson is a Professor of medicinal chemistry at the Faculty of Pharmaceutical Sciences in the University of Iceland. He graduated as a Doctor of Engineering (biotechnology) from Tokyo Institute of Technology, Japan, in 1995 and with a Cand. Scient (MS) in organic chemistry from Copenhagen University, Denmark, in 1990.
Deepagan Veerasikku Gopal is a Research Fellow at Monash Institute of Pharmaceutical Sciences, Australia, since March 2018. He completed his PhD in polymer science and engineering at Sungkyunkwan University, Republic of Korea, and Masters in nanomedicine at Amrita University, India.
