The specificity of certain chemicals to induce a wide variety of differing toxicities, including hepatotoxicity, neurotoxicity, pulmonary toxicity, nephrotoxicity, ototoxicity, and cancer in particular organs is a fascinating problem currently under active investigation in many laboratories.
This two-volume text provides a valuable reference for established investigators and postgraduate student in toxicology. Essential information on the general principles of target organ toxicity is provided in the first volume. It includes the importance of pharmacokinetics, metabolic activation and key defence mechanisms, excretion, species variation, and tissue specific biochemistry. Volume II illustrates these general principles by dealing with specific examples of toxicity to different target organs, such as lung, liver, kidney, nervous system, ear, eye, and the male and female reproductive systems.
