This comprehensive textbook brings together global experts to deliver an in depth, evidence based guide covering the full spectrum of acquired and inherited marrow failure syndromes. It explores cutting edge advances in diagnostics including next generation sequencing , other genetic studies and the evolving progress in treatment strategies including immunosuppressive therapy, hematopoietic stem cell transplantation, and targeted agents. Special attention is given to age specific management, overlap syndromes and the increasingly recognized inherited bone marrow failure disorders. A dedicated section addresses the unique challenges faced in resource limited settings, offering strategies to improve global access to care. Designed for clinicians, researchers, and allied health professionals, this textbook serves as an essential, practical reference that bridges research and real world practice. It equips readers with the tools to improve outcomes for patients worldwide affected by bone marrow failure.
This book is open access.
Epidemiology of Acquired Bone Marrow Failure.- Pathophysiology of
Acquired Bone Marrow Failure.- Role of Next Generation Sequencing in
Diagnosis of Inherited and Acquired Bone Marrow Failure.- Diagnosis of
Acquired Aplastic Anemia.- Acquired Overlap Bone Marrow Failure Disorders.-
Supportive Care in Aplastic Anemia.- Immunosuppressive Therapy for Aplastic
Anemia.- Identical Sibling Donor Transplantation.- Unrelated Donor
Transplants for Acquired Aplastic Anemia.- Umbilical Cord Blood
Transplantation for Patients.- Haploidentical Transplantation.- Management of
Acquired Aplastic Anemia in Children.- Treatment of Elderly Patients with
Aplastic Anemia.- Emerging New Therapies for Acquired Bone Marrow Failure
Disorders.- Bone Marrow Failure in Paroxysmal Nocturnal Hemoglobinuria.-
Managing Bone Marrow Failure in Countries with Restricted Resource.- Telomere
Biology and Disease.- Fanconi Anemia.- Ribosomopathies and the Quality
Control of Ribosome Assembly.- Dyskeratosis Congenita.- Amegakaryocytic
Thrombocytopenia.- Severe Congenital Neutropenias and Other Rare Inherited
Disorders with Marrow Failure.- Bone Marrow Failure Syndromes in Children.
Dr. Mahmoud Aljurf MD Director of Adult Stem Cell Transplantation and Cell Therapy Program Deputy Director of the Oncology Centre King Faisal Specialist Hospital & Research Centre Riyadh, Saudi Arabia
Régis Peffault de Latour Professor of Hematology Department of Hematology and Bone Marrow Transplant Saint-Louis Hospital Paris, France
Antonio M Risitano Head of the Clinical Unit of Hematopoietic Stem Cell Transplantation Department of Hematology Moscati Hospital Avellino, Italy
Andrea Bacigalupo Fondazione Policlinico Universitario Gem Rome, Italy
Carlo Dufour Chair of the Clinical and Experimental Hematology Unit Department of Hematology G. Gaslini Children Research Hospital Genova, Italy
