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Thoracic tumours 5th ed., 2021 [Pehme köide]

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Thoracic Tumours is the fifth available volume in the fifth edition of the WHO series on the classification of human tumours. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education.

What’s new in this edition?

The fifth edition, guided by the WHO Classification of Tumours Editorial Board, establishes a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumour type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria.

Who should read this book?

• Pathologists
• Oncologists
• Respiratory physicians
• Thoracic radiologists
• Cancer researchers
• Surgeons
• Epidemiologists
• Cancer registrars

This volume:

• Prepared by 217 authors and editors
• Contributors from around the world
• More than 1000 high-quality images
• More than 3500 references
List of abbreviations
xi
Foreword xii
ICD-O topographical coding
1(1)
ICD-O morphological coding
1(4)
Tumours of the lung
2(2)
Tumours of the pleura and pericardium
4(1)
Tumours of the heart
5(1)
Mesenchymal tumours of the thorax
6(1)
Tumours of the thymus
7(1)
Germ cell tumours of the mediastinum
8(1)
Haematolymphoid tumours of the mediastinum
8(1)
Ectopic tumours of thyroid and parathyroid origin
9(1)
TNM staging of lung, pleural, and thymic tumours
10(1)
Carcinomas of the lung
11(2)
Pleural mesothelioma
13(1)
Epithelial tumours of the thymus
14(1)
TNM staging of tumours of soft tissues
15(2)
Staging of Hodgkin and non-Hodgkin lymphomas
17(2)
1 Tumours Of The Lung
19(174)
Introduction
20(9)
Small diagnostic samples
29(8)
Epithelial tumours
Papillomas
Bronchial papillomas
37(4)
Adenomas
Sclerosing pneumocytoma
41(3)
Alveolar adenoma
44(2)
Papillary adenoma
46(2)
Bronchiolar adenoma/ciliated muconodular papillary tumour
48(3)
Mucinous cystadenoma
51(2)
Mucous gland adenoma
53(2)
Precursor glandular lesions
Atypical adenomatous hyperplasia
55(2)
Adenocarcinoma in situ
57(3)
Adenocarcinomas
Minimally invasive adenocarcinoma
60(4)
Invasive non-mucinous adenocarcinoma
64(11)
Invasive mucinous adenocarcinoma
75(4)
Colloid adenocarcinoma
79(2)
Fetal adenocarcinoma
81(2)
Enteric-type adenocarcinoma
83(2)
Squamous precursor lesions
Squamous dysplasia and carcinoma in situ
85(4)
Squamous cell carcinomas
Squamous cell carcinoma
89(5)
Lymphoepithelial carcinoma
94(3)
Large cell carcinomas
Large cell carcinoma
97(3)
Adenosquamous carcinoma
Adenosquamous carcinoma
100(3)
Sarcomatoid carcinomas
Pleomorphic carcinoma
103(3)
Pulmonary blastoma
106(3)
Carcinosarcoma
109(2)
Other epithelial tumours
NUT carcinoma of the lung (see Ch. 5)
Thoracic SMARCA4-deficient undifferentiated tumour
111(4)
Salivary gland-type tumours
Pleomorphic adenoma
115(2)
Adenoid cystic carcinoma
117(2)
Epithelial-myoepithelial carcinoma
119(2)
Mucoepidermoid carcinoma
121(2)
Hyalinizing clear cell carcinoma
123(2)
Myoepithelioma and myoepithelial carcinoma
125(2)
Lung neuroendocrine neoplasms
Introduction
127(3)
Precursor lesion
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
130(3)
Neuroendocrine tumours
Carcinoid/neuroendocrine tumour
133(6)
Neuroendocrine carcinomas
Small cell lung carcinoma
139(5)
Large cell neuroendocrine carcinoma
144(6)
Tumours of ectopic tissues
Melanoma
150(2)
Meningioma
152(2)
Mesenchymal tumours specific to the lung
Pulmonary hamartoma
154(2)
Pulmonary chondroma
156(2)
Diffuse pulmonary lymphangiomatosis
158(2)
Pleuropulmonary blastoma
160(4)
Pulmonary artery intimal sarcoma
164(2)
Congenital peribronchial myofibroblastic tumour
166(2)
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion
168(2)
PEComatous tumours
Lymphangioleiomyomatosis
170(2)
PEComa
172(2)
Haematolymphoid tumours
Introduction
174(1)
MALT lymphoma
175(3)
Diffuse large B-cell lymphoma
178(3)
Lymphomatoid granulomatosis
181(3)
Intravascular large B-cell lymphoma
184(2)
Pulmonary Langerhans cell histiocytosis
186(3)
Erdheim-Chester disease
189(4)
2 Tumours Of The Pleura And Pericardium
193(34)
Introduction
194(2)
Mesothelial tumours
Benign and preinvasive mesothelial tumours
Adenomatoid tumour
196(2)
Well-differentiated papillary mesothelial tumour
198(2)
Mesothelioma in situ
200(2)
Mesothelioma
Localized mesothelioma
202(2)
Diffuse mesothelioma
204(16)
Haematolymphoid tumours
Introduction
220(1)
Primary effusion lymphoma
221(3)
Diffuse large B-cell lymphoma associated with chronic inflammation
224(3)
3 Tumours Of The Heart
227(46)
Introduction
228(2)
Benign tumours
Papillary fibroelastoma
230(3)
Cardiac myxoma
233(4)
Cardiac fibroma
237(2)
Cardiac rhabdomyoma
239(2)
Adult cellular rhabdomyoma
241(2)
Cardiac lipoma and lipomatous hypertrophy of the atrial septum
243(2)
Lipomatous hamartoma of the atrioventricular valve
245(2)
Hamartoma of mature cardiac myocytes
247(2)
Mesenchymal cardiac hamartoma
249(2)
Cardiac haemangiomas
251(2)
Conduction system hamartoma
253(3)
Cystic tumour of the atrioventricular node
256(2)
Malignant tumours
Cardiac angiosarcoma
258(2)
Cardiac leiomyosarcoma
260(2)
Cardiac undifferentiated pleomorphic sarcoma
262(3)
Other sarcomas that may involve the heart
265(1)
Haematolymphoid tumours
Introduction
266(1)
Cardiac diffuse large B-cell lymphoma
267(2)
Cardiac fibrin-associated diffuse large B-cell lymphoma
269(4)
4 Mesenchymal Tumours Of The Thorax
273(46)
Introduction
274(2)
Mesenchymal tumours
Adipocytic tumours Lipoma
276(2)
Thymolipoma
278(2)
Liposarcoma
280(2)
Fibroblastic and myofibroblastic tumours Desmoid fibromatosis
282(2)
Solitary fibrous tumour
284(2)
Calcifying fibrous tumour
286(2)
Inflammatory myofibroblastic tumour
288(2)
Myxofibrosarcoma
290(2)
Vascular tumours
Haeniangioma
292(2)
Lymphangioma
294(2)
Epithelioid haemangioendothelioma
296(3)
Angiosarcoma
299(2)
Skeletal muscle tumours
Rhabdomyosarcoma
301(2)
Peripheral nerve sheath and neural tumours Paraganglioma
303(2)
Granular cell tumour
305(2)
Schwannoma
307(2)
Malignant peripheral nerve sheath tumour
309(2)
Peripheral neuroblastic tumours
311(3)
Tumours of uncertain differentiation Synovial sarcoma
314(2)
Undifferentiated small round cell sarcomas
316(3)
5 Tumours Of The Thymus
319(80)
Epithelial tumours
Thymoma
Introduction
320(6)
Type A thymoma (including atypical subtype)
326(3)
Type AB thymoma
329(3)
Type B1 thymoma
332(4)
Type B2 thymoma
336(4)
Type B3 thymoma
340(5)
Micronodular thymoma with lymphoid stroma
345(2)
Metaplastic thymoma
347(2)
Lipofibroadenoma
349(2)
Thymic carcinoma
Introduction
351(3)
Squamous cell carcinoma
354(5)
Basaloid carcinoma
359(2)
Lymphoepithelial carcinoma
361(3)
NUT carcinoma of the thorax
364(4)
Clear cell carcinoma
368(2)
Low-grade papillary adenocarcinoma
370(2)
Mucoepidermoid carcinoma
372(3)
Thymic carcinoma with adenoid cystic carcinoma-like features
375(2)
Enteric-type adenocarcinoma
377(2)
Adenocarcinoma NOS
379(2)
Adenosquamous carcinoma
381(2)
Sarcomatoid carcinoma
383(3)
Undifferentiated carcinoma
386(2)
Thymic carcinoma NOS
388(1)
Thymic neuroendocrine neoplasms Introduction
Neuroendocrine tumours
389(2)
Carcinoid/neuroendocrine tumour
391(4)
Neuroendocrine carcinomas Small cell carcinoma
395(2)
Large cell neuroendocrine carcinoma
397(2)
6 Germ Cell Tumours Of The Mediastinum
399(26)
Introduction
400(2)
Seminoma
402(3)
Embryonal carcinoma
405(2)
Yolk sac tumour
407(5)
Choriocarcinoma
412(2)
Teratoma
414(3)
Mixed germ cell tumours
417(2)
Germ cell tumours with somatic-type solid malignancy
419(3)
Germ cell tumours with associated haematological malignancy
422(3)
7 Haematolymphoid Tumours Of The Mediastinum
425(20)
Introduction
426(1)
Primary mediastinal large B-cell lymphoma
427(3)
MALT lymphoma
430(2)
T-lymphoblastic leukaemia/lymphoma
432(3)
Classic Hodgkin lymphoma
435(3)
Mediastinal grey zone lymphoma
438(3)
Follicular dendritic cell sarcoma
441(2)
Myeloid sarcoma
443(2)
8 Ectopic Tumours Of Thyroid And Parathyroid Origin
445(6)
Ectopic thyroid tumours
446(2)
Ectopic parathyroid tumours
448(3)
9 Metastases
451(20)
Metastasis to the lung
452(7)
Metastasis to the pleura
459(4)
Metastasis to the thymus and mediastinal lymph nodes
463(4)
Metastasis to the heart and pericardium
467(4)
10 Genetic Tumour Syndromes Involving The Thorax
471(10)
Introduction
472(2)
Li-Fraumeni syndrome
474(2)
BAP1 tumour predisposition syndrome
476(2)
Carney complex
478(3)
Contributors 481(7)
Declaration of interests 488(2)
IARC/WHO Committee for ICD-0 490(1)
Sources 491(8)
References 499(56)
Subject index 555(10)
Previous volumes in the series 565