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Toxicological evaluation of certain veterinary drug residues in food [Pehme köide]

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  • Formaat: Paperback / softback, 183 pages, kõrgus: 230 mm, figs, tables
  • Sari: WHO food additives series 66
  • Ilmumisaeg: 26-Mar-2012
  • Kirjastus: World Health Organization
  • ISBN-10: 924166066X
  • ISBN-13: 9789241660662
Teised raamatud teemal:
Toxicological evaluation of certain veterinary drug residues in foodSuurem pilt
  • Formaat: Paperback / softback, 183 pages, kõrgus: 230 mm, figs, tables
  • Sari: WHO food additives series 66
  • Ilmumisaeg: 26-Mar-2012
  • Kirjastus: World Health Organization
  • ISBN-10: 924166066X
  • ISBN-13: 9789241660662
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9789241660662.html
Märksõnad:
This volume contains monographs prepared at the seventy-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met in Rome, Italy, from 8 to 17 November 2011.

The toxicological monographs in this volume summarize data on the veterinary drug residues that were evaluated toxicologically by the Committee: the antimicrobial agents amoxicillin and apramycin and the anthelminthics derquantel and monepantel. This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
Preface v
Residues of veterinary drugs
Amoxicillin
3(36)
1 Explanation
4(1)
2 Biological data
5(22)
2.1 Biochemical aspects
5(4)
2.1.1 Absorption, distribution and excretion
5(1)
a Laboratory animals
5(1)
b Humans
6(2)
2.1.2 Biotransformation
8(1)
2.2 Toxicological studies
9(14)
2.2.1 Acute toxicity
9(1)
a Mice
9(1)
b Rats
9(1)
c Dogs
9(1)
2.2.2 Short-term studies of toxicity
10(1)
a Rats
10(1)
b Cats
11(1)
c Dogs
12(1)
2.2.3 Long-term studies of toxicity and carcinogenicity
12(1)
2.2.4 Genotoxicity
12(1)
2.2.5 Reproductive and developmental toxicity
13(1)
a Reproductive toxicity
13(1)
b Developmental toxicity
16(1)
2.2.6 Special studies on microbiological effects
17(6)
2.3 Observations in humans
23(4)
2.3.1 Gastrointestinal effects
23(1)
2.3.2 Allergen and immune response
23(1)
2.3.3 Hepatotoxicity
24(1)
2.3.4 Reproductive toxicity
25(2)
3 Comments
27(4)
3.1 Biochemical data
27(1)
3.2 Toxicological data
27(3)
3.3 Microbiological data
30(1)
4 Evaluation
31(1)
5 References
32(7)
Apramycin
39(26)
1 Explanation
40(1)
2 Biological data
41(14)
2.1 Biochemical aspects
41(1)
2.1.1 Absorption, distribution and excretion
41(1)
a Rats
41(1)
b Dogs
41(1)
2.1.2 Biotransformation
42(1)
2.2 Toxicological studies
42(13)
2.2.1 Acute toxicity
42(1)
a Single-dose toxicity
42(1)
b Irritation and sensitization
43(1)
2.2.2 Short-term studies of toxicity
44(1)
a Mice
44(1)
b Rats
44(1)
c Dogs
45(1)
d Chickens
46(1)
e Pigs
46(1)
f Cattle
47(1)
2.2.3 Long-term studies of toxicity and carcinogenicity
47(1)
a Mice
47(1)
b Rats
47(1)
2.2.4 Genotoxicity
48(1)
2.2.5 Reproductive and developmental toxicity
48(1)
a Multigeneration studies in rats
48(1)
b Reproductive toxicity in pigs
49(1)
c Developmental toxicity
49(1)
2.2.6 Special studies
50(1)
a Gastrointestinal irritation
50(1)
b Kidney toxicity
50(1)
c Ototoxicity
50(1)
d Pharmacology
50(1)
e Microbiological effects
51(4)
2.3 Observations in humans
55(1)
3 Comments
55(5)
3.1 Biochemical data
55(1)
3.2 Toxicological data
55(4)
3.3 Microbiological data
59(1)
4 Evaluation
60(1)
5 References
60(5)
Derquantel
65(54)
1 Explanation
66(1)
2 Biological data
67(37)
2.1 Biochemical aspects
67(7)
2.1.1 Absorption, distribution and excretion
67(1)
a Rats
67(1)
b Rabbits
69(1)
c Dogs
69(1)
d Horses
70(1)
2.1.2 Biotransformation
71(1)
2.1.3 Effects on enzymes and other biochemical parameters
72(2)
2.2 Toxicological studies
74(26)
2.2.1 Acute toxicity
74(1)
a Single-dose toxicity studies
74(1)
b Dermal sensitization
76(1)
c Dermal irritation
76(1)
d Ocular irritation
77(1)
2.2.2 Short-term studies of toxicity
77(1)
a Rats
77(1)
b Dogs
88(5)
2.2.3 Long-term studies of toxicity and carcinogenicity
93(1)
2.2.4 Genotoxicity
93(1)
2.2.5 Reproductive and developmental toxicity
94(1)
a Multigeneration studies
94(1)
b Developmental toxicity
96(3)
2.2.6 Special studies
99(1)
a Structural toxicity alerts for derquantel and related impurities
99(1)
b Impurities
99(1)
c Microbiological effects
100(1)
2.3 Toxicological studies with derquantel/abamectin (Startect)
100(4)
2.3.1 Acute toxicity
100(1)
2.3.2 Short-term studies of toxicity
101(3)
2.4 Observations in humans
104(1)
3 Comments
104(9)
3.1 Biochemical data
104(2)
3.2 Toxicological data
106(7)
3.3 Microbiological data
113(1)
4 Evaluation
113(1)
5 References
113(6)
Monepantel
119(40)
1 Explanation
120(1)
2 Biological data
121(27)
2.1 Biochemical aspects
121(8)
2.1.1 Absorption, distribution and excretion
121(1)
a Rats
121(1)
b Dogs
122(1)
c Sheep
123(1)
d Protein binding in vitro
123(1)
2.1.2 Biotransformation
124(1)
a Rats
124(1)
b Sheep
125(1)
c In vitro
128(1)
2.1.3 Effects on enzymes and other biochemical parameters
128(1)
2.2 Toxicological studies
129(19)
2.2.1 Acute toxicity
129(1)
2.2.2 Short-term studies of toxicity
129(1)
a Mice
129(1)
b Rats
131(1)
c Dogs
134(1)
d Target species: Sheep and Iamb
139(1)
2.2.3 Long-term studies of toxicity and carcinogenicity
139(2)
2.2.4 Genotoxicity
141(2)
2.2.5 Reproductive and developmental toxicity
143(1)
a Multigeneration studies
143(1)
b Developmental toxicity
145(2)
2.2.6 Special studies
147(1)
a Cardiovascular and respiratory end-points
147(1)
b Behavioural end-points
147(1)
c Gastrointestinal end-points
147(1)
d Immune responses
148(1)
e Microbiological effects
148(1)
2.3 Observations in humans
148(1)
3 Comments
148(6)
3.1 Biochemical data
148(1)
3.2 Toxicological data
149(4)
3.3 Microbiological data
153(1)
4 Evaluation
154(1)
5 References
154
Annexes
Annex 1 Reports and other documents resulting from previous meetings of the Joint FAO/WHO Expert Committee on Food Additives
159(12)
Annex 2 Abbreviations used in the monographs
171(2)
Annex 3 Participants in the seventy-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives
173(2)
Annex 4 Recommendations on compounds on the agenda and further information required
175