Muutke küpsiste eelistusi

Toxicological evaluation of certain veterinary drug residues in food [Pehme köide]

  • Formaat: Paperback / softback, 167 pages, kõrgus: 230 mm, col. figs, tables
  • Sari: WHO food additives series 72
  • Ilmumisaeg: 01-Jun-2016
  • Kirjastus: World Health Organization
  • ISBN-10: 9241660724
  • ISBN-13: 9789241660723
Teised raamatud teemal:
  • Formaat: Paperback / softback, 167 pages, kõrgus: 230 mm, col. figs, tables
  • Sari: WHO food additives series 72
  • Ilmumisaeg: 01-Jun-2016
  • Kirjastus: World Health Organization
  • ISBN-10: 9241660724
  • ISBN-13: 9789241660723
Teised raamatud teemal:
Based on working papers prepared by World Health Organization experts, this volume brings together work prepared at the 81st meeting of the Joint FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization) Expert Committee on Food Additives (JECFA), held in Rome, Italy, in November 2015. They summarize data on the safety of veterinary drug residues in food evaluated toxicologically by the Committee (diflubenzuron, ivermectin, sisapronil, and teflubenzuron) and include a summary of the Committee’s recommendations on these and other drugs discussed at the meeting, including acceptable daily intakes, acute reference doses, and proposed maximum residue limits. Each paper details biochemical aspects, toxicological studies, observations in humans, and comments on the biochemical, toxicological, and microbiological data. Annotation ©2017 Ringgold, Inc., Portland, OR (protoview.com)

This volume contains monographs prepared at the eighty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met in Rome, Italy, from 17 to 26 November 2015.

The toxicological monographs in this volume summarize data on the veterinary drug residues that were evaluated toxicologically by the Committee: diflubenzuron, ivermectin, sisapronil and teflubenzuron. Annexed to the report is a summary of the Committee's recommendations on these and other drugs discussed at the eighty-first meeting, including acceptable daily intakes (ADIs), acute reference doses (ARfDs) and proposed maximum residue limits (MRLs).

This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
1 Explanation
4(2)
2 Biological data
6(29)
2.1 Biochemical aspects
6(7)
2.1.1 Absorption, distribution and excretion
6(1)
(a) Oral administration
6(3)
(b) Dermal application
9(1)
2.1.2 Biotransformation
9(1)
(a) Rats
9(2)
(b) Other species
11(2)
2.1.3 Effects on enzymes and other biochemical parameters
13(1)
2.2 Toxicological studies
13(22)
2.2.1 Acute toxicity
13(1)
(a) Lethal doses
13(1)
(b) Dermal irritation
13(1)
(c) Ocular irritation
14(1)
(d) Dermal sensitization
14(1)
2.2.2 Short-term studies of toxicity
14(1)
(a) Oral administration
14(3)
(b) Dermal application
17(1)
(c) Exposure by inhalation
18(1)
2.2.3 Long-term studies of toxicity and carcinogenicity
18(1)
(a) Mice
18(1)
(b) Rats
19(3)
2.2.4 Genotoxicity
22(3)
2.2.5 Reproductive and developmental toxicity
25(1)
(a) Multigeneration reproductive toxicity
25(1)
(b) Developmental toxicity
26(1)
2.2.6 Special studies
27(1)
(a) Metabolite: 4-chlorophenylurea (CPU)
27(1)
(b) Metabolite: p-chloroaniline (PCA)
28(7)
(c) Microbiological effects
35(1)
2.3 Observations in humans
35(1)
3 Comments
35(8)
3.1 Biochemical data
35(1)
3.2 Toxicological data
36(5)
3.3 Toxicological data on PCA (a metabolite of diflubenzuron)
41(2)
3.4 Observations in humans
43(1)
3.5 Microbiological data
43(1)
4 Evaluation
43(1)
4.1 Additional information that would assist in the further evaluation of the compound
43(1)
4.2 Recommendation
43(1)
5 References
44