First Published in 1986, this two-volume set explores the methods of toxicological risk assessment. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for toxicologists and other practitioners in their respective fields.
Volume I.
SECTION A BIOLOGICAL CRITERIA.
1. Interspecies Exploration of Drug and Genetic Toxicity Data.
2.
Pharmacokinetic Differences Between Species.
3. Differences in Metabolism at
Different Dose Levels.
4. Toxicological Effects on Carcinogenesis.
5.
Problems in Interspecies Exploration.
SECTION B STATISTICAL CRITERIA.
6. Statistical Design and Analysis of the Long-Term Carcinogenicity
Bioassay.
7. Statistical Analysis of Rodent Tumorigenicity Experiments. 8.
Use of the Hartley-Sielken Model in Low-Dose Extrapolation.
9. A Review of
Methods for Calculating Statistical Confidence Limits in Low-Dose
Extrapolation. 10. Incorporation of Pharmacokinetics in Low-Dose Risk
Estimation. Index.
Volume II.
SECTION A GENERAL CRITERIA.
1. Epidemiological Methods for the Assessment of Human Cancer at Risk. 2.
Assessment of Human Exposure to Environmental Contaminants with Special
Reference. 3. The Influence of Nutrition, Immunologic Status, and Other
Factors on the Development of Cancer.
4. The Significance of Benefits in
Regulatory Decision Making. 5. Measuring Health Benefits. 6. Food Safety
Regulations.
SECTION B CASE STUDIES
7. Case Study Asbestos. 8. Vinyl Chloride A Cancer Case Study.
9. An
Integrated Approach to the Study of Formaldehyde Carcinogenicity in Rats and
Mice.
10. Determination of Human Risk in Regulating Polychlorinated
Biphenyls (PCBs) A Case Study. 11. Saccharin A Bitter Sweet Case. Index.
D. B. Clayson, D. Krewski, I. Munro
