The definitive resource for understanding infectious disease in veterinary medicine
The revised third edition of Veterinary Microbiology and Microbial Disease equips veterinary professionals with essential knowledge of bacteriology, mycology and virology. Serving as both an authoritative reference and practical clinical guide to infectious disease, the authors provide up-to-date information relevant to animal and public health, along with the latest diagnostic tools and the information required to treat and control them.
This new edition incorporates substantial advances in molecular biology and genome sequencing that have transformed veterinary microbiology. New material also addresses contemporary challenges in infectious disease management, such as drug-resistant microorganisms, zoonotic pathogens, and other emerging threats.
Readers will find:
Expanded coverage of molecular diagnostic methods and genome sequencing for pathogen identification and characterization Comprehensive analysis of antibacterial resistance mechanisms, multiple drug resistance patterns, and their implications for zoonotic and nosocomial pathogens Updated taxonomy of important pathogens in line with the recommendations of international committees Colour photographs illustrating important grossly- and microscopically-visible responses to infectious agents A fully revised section on the interactions of microbial pathogens with animal body systems to facilitate a systematic approach to investigating the role of infectious agents in disease production and differential diagnosis Access to a companion website providing all figures from the text as downloadable slides for educational use
Veterinary Microbiology and Microbial Disease provides undergraduate and postgraduate veterinary students, practicing veterinary surgeons, researchers, and graduates specializing in diagnostic microbiology or regulatory activities with up-to-date information on bacterial, fungal, and viral pathogens.
Preface ix
Acknowledgements x
Author biographies xi
About the Companion Website xiv
Section I Introduction to Microbiology, Infection, Immunity and Molecular
Diagnostic Methods
1 Microbiology, microbial pathogens and infectious disease 3
2 Subdivisions, classification and morphological characterization of
infectious agents 8
3 Immunity and infection 14
4 Immune system disorders 78
5 Vaccines and vaccination 96
6 Molecular diagnostic methods 114
Section II Introductory Bacteriology
7 The structure of bacterial cells and bacterial taxonomy 143
8 Cultivation, preservation and inactivation of bacteria 151
9 Bacterial genetics, mechanisms of genetic variation and gene databases
158
10 Laboratory diagnosis of bacterial disease 177
11 Antibacterial agents 183
12 Antibacterial resistance 192
13 Bacterial colonization, tissue invasion and clinical disease 202
Section III Pathogenic Bacteria
14 Overview of bacteria of veterinary importance 217
15 Staphylococcus species 225
16 Streptococcus species and Enterococcus species 233
17 Actinomycetes 242
18 Corynebacterium species 253
19 Rhodococcus equi 260
20 Listeria species 264
21 Erysipelothrix rhusiopathiae 269
22 Bacillus species 273
23 Clostridium and Clostridioides species 280
24 Mycobacterium species 296
25 Enterobacterales 309
26 Pseudomonas aeruginosa and Burkholderia species 335
27 Actinobacillus species 342
28 Pasteurella species, Mannheimia haemolytica and Bibersteinia trehalosi
349
29 Francisella tularensis 358
30 Histophilus somni, Glaesserella parasuis, Avibacterium paragallinarum and
Gallibacterium anatis 362
31 Taylorella species 369
32 Bordetella species 372
33 Moraxella species 378
34 Brucella species 382
35 Campylobacter and Helicobacter species 390
36 Lawsonia intracellularis 397
37 Spirochaetes 400
38 Pathogenic anaerobic non-spore-forming Gram-negative bacteria 415
39 Mycoplasmas 421
40 Chlamydia species 432
41 Rickettsiales and Coxiella burnetii 442
42 Bacterial species of limited pathogenic significance in animals 453
Section IV Mycology
43 General features of fungi and an overview of their veterinary importance
461
44 Dermatophytes 471
45 Aspergillus species 478
46 Yeasts and disease production 484
47 Dimorphic fungi 494
48 Zygomycetes of veterinary importance 502
49 Fungus-like organisms of veterinary importance 508
50 Pneumocystis species 513
51 Opportunistic infections caused predominantly by phaeoid fungi 516
52 Mycotoxins and mycotoxicoses 520
53 Pathogenic algae and cyanobacteria 535
54 Antifungal chemotherapy 541
Section V Introductory Virology
55 Nature, structure and taxonomy of viruses 561
56 Replication of viruses 572
57 Virus evolution 580
58 Propagation of viruses and viruscell interactions 585
59 Pathogenesis of viral diseases 590
60 Laboratory diagnosis of viral infections 597
61 Antiviral chemotherapy 603
Section VI Viruses and Prions
62 Overview of viruses of veterinary importance 623
63 Orthoherpesviridae 628
64 Papillomaviridae 645
65 Adenoviridae 651
66 Poxviridae 657
67 Asfarviridae 668
68 Parvoviridae 672
69 Circoviridae and Anelloviridae 681
70 Retroviridae 685
71 Sedoreoviridae and Spinareoviridae 701
72 Birnaviridae 710
73 Orthomyxoviridae 714
74 Paramyxoviridae and Pneumoviridae 723
75 Rhabdoviridae 736
76 Bornaviridae 743
77 Peribunyaviridae, Nairoviridae, Phenuiviridae and Hantaviridae 746
78 Picornaviridae 752
79 Caliciviridae 762
80 Astroviridae 768
81 Coronaviridae 771
82 Arteriviridae 784
83 Flaviviridae 790
84 Togaviridae 801
85 Prions: unconventional infectious agents 806
Section VII Microbial Agents and Disease
86 Lesions resulting from interaction of bacterial, fungal and viral
pathogens with host organ systems 817
87 Interactions of microbial pathogens with the nervous system 819
88 Interactions of microbial pathogens with the male and female reproductive
systems 828
89 The role of microbial pathogens in intestinal and liver disease 837
90 The role of microbial pathogens in respiratory disease 849
91 Interactions of microbial pathogens with the urinary system 859
92 Microbial diseases of the cardiovascular system 870
93 Interactions of microbial pathogens with the musculoskeletal system 880
94 The role of microbial pathogens in diseases of the integumentary system
895
95 Bacterial causes of bovine mastitis 908
96 Disinfection, biosecurity and other aspects of disease control 922
Appendix: Relevant websites 966
Index 969
Patrick Joseph Quinn MVB, PhD, MRCVS (deceased 2025) was Professor Emeritus of Veterinary Microbiology and Parasitology at the School of Veterinary Medicine, University College Dublin, Ireland
Bryan K. Markey MVB, PhD, DipStat, Dipl.ECVM, MRCVS is former Professor of Veterinary Microbiology and EBVS® European Specialist in Veterinary Microbiology at the School of Veterinary Medicine, University College Dublin, Ireland
Finola C. Leonard MVB, PhD, Dipl.ECVM, MRCVS is Professor of Veterinary Microbiology and EBVS® European Specialist in Veterinary Microbiology at the School of Veterinary Medicine, University College Dublin, Ireland
Joseph P. Cassidy MVB, PhD, FRCPath, MRCVS is Associate Professor of Veterinary Pathology at the School of Veterinary Medicine, University College Dublin, Ireland
Stephen V. Gordon BSc, PhD is Professor of Infection Biology at the Schools of Veterinary Medicine; Biomolecular and Biomedical Science; and Medicine, University College Dublin, Ireland
Séamus Fanning BSc, PhD, FAAM, DSc is Professor of Food Safety and Zoonoses at the School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland
Gerald Barry MSc, PhD is Assistant Professor of Virology at the School of Veterinary Medicine, University College Dublin, Ireland
Eamonn S. FitzPatrick FIBMS, FRMS is former Chief Technical Officer at the School of Veterinary Medicine, University College Dublin, Ireland
Aidan P. Kelly is former Chief Technical Officer at the School of Veterinary Medicine, University College Dublin, Ireland
Kieran G. Meade BAgrSc, PhD, Dipl. T&L is Professor of Immunobiology at the School of Agriculture and Food Science, University College Dublin, Ireland
