The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
Tools for optogenetic probing of nociceptive pathways; Monitoring
activity.- An open science model to accelerate the generation, implementation
and distribution of optogenetics and viral tools.- Vagal neuroinflammation
accompanying respiratory viral infection: An overview of mechanisms and
possible clinical significance.- Stress-induced Visceral Analgesia: Concept
and Pathways.- Evidence of early life stress exposure and epigenetic
modifications in functional chronic pain disorders.- EPIGENETIC REGULATION OF
STRESS-INDUCED VISCERAL PAIN.- The biomechanics and mechanotransduction in
visceral nociception.- VISCERAL NOCICEPTION IN GASTROINTESTINAL
DISEASE.- Epithelial-Neuronal Communication in Visceral Pain.- Physiological
Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling
in Irritable Bowel Syndrome.- A fentanyl analogue that activates u-opioid
receptors in acidified tissues inhibits colitis pain without opioid side
effects.- Signalling in the Gut.- Translating colonic sensory afferent
peripheral mechanosensitivity into the spinal cord dorsal horn.- Translating
colonic afferent peripheral sensitivity into the spinal cord dorsal
horn.- Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain.- Pre-clinical
Models of Endometriosis.- Spinal afferent innervation of the
uterus.- Post-infectious bladder hypersensitivity in the development of
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
Dr. Stuart Brierley, PhD, is a Matthew Flinders Professor in Gastrointestinal Neuroscience, a NHMRC Investigator Leadership Fellow and Director of the Visceral Pain Research Group at Flinders University in Adelaide, South Australia. He is also Director of the Hopwood Centre for Neurobiology and co-lead of the Lifelong Health Theme at the South Australian Health & Medical Research Institute in Adelaide.
Dr. Nick Spencer, PhD is a Mathew Flinders Professor of Neurophysiology at Flinders Medical Centre in Adelaide, South Australia.
