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WHO classification of tumours of the urinary system and male genital organs 5th ed [Pehme köide]

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Urinary and Male Genital Tumours is Volume 8 in the 5th edition of the WHO series on the classification of human tumors.

This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumors and comprises a unique synthesis of histopathological diagnosis withdigital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education.

What’s new in this edition?

The 5th edition, guided by the WHO Classification of Tumours Editorial Board, will establish a single coherent cancer classification presented across a collection of individual volumes organized on the basis of anatomical site (digestive system, breast, soft tissue and bone, etc.) and structured in a systematic manner, with each tumor type listed within a taxonomic classification: site, category, family (class), type, and subtype. In each volume, the entities are now listed from benign to malignant and are described under an updated set of headings, including histopathology, diagnostic molecular pathology, staging, and easy-to-read essential and desirable diagnostic criteria.

Who should read this book?
  • Pathologists
  • Urologists
  • Radiologists
  • Medical oncologists
  • Radiation oncologists
  • Surgeons
  • Oncology nurses
  • Cancer researchers
  • Epidemiologists
  • Cancer registrars
This volume:
  • Prepared by 181 authors and editors
  • Contributors from around the world
  • More than 900 high-quality images
  • More than 3600 references
List of abbreviations
xi
Foreword xii
ICD-O topographical coding
1(1)
ICD-0 morphological coding
1(15)
Tumours of the kidney
2(2)
Tumours of the urinary tract
4(2)
Tumours of the prostate
6(1)
Tumours of the seminal vesicle
7(1)
Tumours of the testis
8(2)
Tumours of the testicular adnexa
10(1)
Tumours of the penis and scrotum
11(1)
Neuroendocrine neoplasms
12(1)
Mesenchymal tumours
12(2)
Haematolymphoid tumours
14(1)
Melanocyte lesions
15(1)
TNM staging of urological tumours
16(11)
Carcinomas of the penis
17(1)
Adenocarcinomas of the prostate
18(2)
Germ cell tumours of the testis
20(2)
Renal cell carcinoma
22(1)
Carcinomas of the renal pelvis and ureter
23(1)
Carcinomas of the urinary bladder
24(1)
Carcinomas of the urethra
25(2)
1 Introduction to urinary and male genital tumours
27(4)
2 Tumours of the kidney
31(100)
Renal cell tumours
Introduction
32(6)
Clear cell renal tumours
Clear cell renal cell carcinoma
38(5)
Multilocular cystic renal neoplasm of low malignant potential
43(2)
Papillary renal tumours
Renal papillary adenoma
45(2)
Papillary renal cell carcinoma
47(3)
Oncocytic and chromophobe renal tumours Oncocytoma of the kidney
50(3)
Chromophobe renal cell carcinoma
53(3)
Other oncocytic tumours of the kidney
56(3)
Collecting duct tumours
Collecting duct carcinoma
59(2)
Other renal tumours
Clear cell papillary renal cell tumour
61(2)
Mucinous tubular and spindle cell carcinoma
63(2)
Tubulocystic renal cell carcinoma
65(2)
Acquired cystic disease-associated renal cell carcinoma
67(2)
Eosinophilic solid and cystic renal cell carcinoma
69(2)
Renal cell carcinoma NOS
71(1)
Molecularly defined renal carcinomas TFE3-rearranged renal cell carcinomas
72(2)
TFEB-altered renal cell carcinomas
74(2)
ELOC (formerly TCES1)-mutated renal cell carcinoma
76(2)
Fumarate hydratase-deficient renal cell carcinoma
78(2)
Succinate dehydrogenase-deficient renal cell carcinoma
80(2)
ALK-rearranged renal cell carcinomas
82(2)
SMARCBI-deficient renal medullary carcinoma
84(3)
Metanephric tumours
Metanephric adenoma
87(3)
Metanephric adenofibroma
90(2)
Metanephric stromal tumour
92(2)
Mixed epithelial and stromal renal tumours
Mixed epithelial and stromal tumour of the kidney
94(2)
Paediatric cystic nephroma
96(2)
Renal mesenchymal tumours
Adult renal mesenchymal tumours
Classic angiomyolipoma / PEComa of the kidney
98(4)
Epithelioid angiomyolipoma / epithelioid PEComa of the kidney
102(3)
Renal haemangioblastoma
105(2)
Juxtaglomerular cell tumour
107(2)
Renomedullary interstitial cell tumour
109(2)
Paediatric renal mesenchymal tumours
Ossifying renal tumour of infancy
111(1)
Congenital mesoblastic nephroma
112(2)
Rhabdoid tumour of the kidney
114(2)
Clear cell sarcoma of the kidney
116(3)
Embryonal neoplasms of the kidney
Nephroblastic tumours
Nephrogenic rests
119(2)
Cystic partially differentiated nephroblastoma
121(2)
Nephroblastoma
123(6)
Miscellaneous renal tumours
Germ cell tumours of the kidney
129(2)
3 Tumours of the urinary tract
131(62)
Introduction
132(2)
Urothelial tumours
Non-invasive urothelial neoplasms
Urothelial papilloma
134(2)
Inverted urothelial papilloma
136(2)
Papillary urothelial neoplasm of low malignant potential
138(2)
Non-invasive papillary urothelial carcinoma, low-grade
140(3)
Non-invasive papillary urothelial carcinoma, high-grade
143(4)
Urothelial carcinoma in situ
147(3)
Invasive urothelial neoplasms
Invasive urothelial carcinoma
150(16)
Squamous cell neoplasms of the urinary tract Squamous papilloma of the urothelial tract
166(6)
Squamous cell carcinomas of the urinary tract Verrucous carcinoma of the bladder
167(2)
Pure squamous carcinoma of the urothelial tract
169(3)
Glandular neoplasms
Adenomas
Villous adenoma
172(1)
Adenocarcinomas
Adenocarcinoma NOS
173(4)
Urachal and diverticular neoplasms
Urachal carcinoma
177(4)
Diverticular carcinoma
181(2)
Urethral neoplasms
Urethral accessory gland carcinomas
Littre gland adenocarcinoma
183(2)
Skene gland adenocarcinoma
185(1)
Cowper gland adenocarcinoma
186(2)
Tumours of Mullerian type
Clear cell adenocarcinoma of the urinary tract
188(2)
Endometrioid carcinoma of the urinary tract
190(3)
4 Tumours of the prostate
193(42)
Introduction
194(2)
Epithelial tumours of the prostate
Glandular neoplasms of the prostate
Prostatic cystadenoma
196(2)
High-grade prostatic intraepithelial neoplasia
198(2)
Intraductal carcinoma of the prostate
200(3)
Prostatic acinar adenocarcinoma
203(17)
Prostatic ductal adenocarcinoma
220(3)
Treatment-related neuroendocrine prostatic carcinoma
223(2)
Squamous neoplasms of the prostate
Adenosquamous carcinoma of the prostate
225(2)
Squamous cell carcinoma of the prostate
227(2)
Adenoid cystic (basal cell) carcinoma of the prostate
229(2)
Mesenchymal tumours unique to the prostate
Stromal tumours of the prostate
Prostatic stromal tumour of uncertain malignant potential
231(2)
Prostatic stromal sarcoma
233(2)
5 Tumours of the seminal vesicle
235(8)
Introduction
236(1)
Epithelial tumours
Glandular neoplasms
Cystadenoma
237(1)
Adenocarcinoma
238(2)
Squamous neoplasms
Squamous cell carcinoma
240(1)
Other tumours
Mixed epithelial and stromal tumour
241(2)
6 Tumours of the testis
243(78)
Introduction
244(6)
Germ cell tumours derived from germ cell neoplasia in situ Non-invasive germ cell neoplasia
Germ cell neoplasia in situ
250(3)
Specific forms of intratubular germ cell neoplasia
253(2)
Gonadoblastoma
255(3)
The germinoma family of tumours Seminoma
258(4)
Non-seminomatous germ cell tumours Embryonal carcinoma
262(3)
Yolk sac tumour, postpubertal-type
265(3)
Choriocarcinoma
268(3)
Placental site trophoblastic tumour
271(2)
Epithelioid trophoblastic tumour
273(2)
Cystic trophoblastic tumour
275(2)
Teratoma, postpubertal-type
277(4)
Teratoma with somatic-type malignancy
281(3)
Mixed germ cell tumours of the testis
Mixed germ cell tumours
284(2)
Germ cell tumours of unknown type
Regressed germ cell tumours
286(2)
Germ cell tumours unrelated to germ cell neoplasia in situ
Spermatocytic tumour
288(3)
Teratoma, prepubertal-type
291(2)
Yolk sac tumour, prepubertal-type
293(2)
Testicular neuroendocrine tumour, prepubertal-type
295(2)
Mixed teratoma and yolk sac tumour, prepubertal-type
297(2)
Sex cord stromal tumours of the testis
Leydig cell tumour
Leydig cell tumour
299(3)
Sertoli cell tumours
Sertoli cell tumour
302(3)
Large cell calcifying Sertoli cell tumour
305(2)
Granulosa cell tumours
Adult granulosa cell tumour
307(2)
Juvenile granulosa cell tumour
309(2)
The fibroma thecoma family of tumours
Tumours in the fibroma thecoma group
311(2)
Mixed and other sex cord stromal tumours
Mixed sex cord stromal tumour
313(2)
Signet ring stromal tumour
315(2)
Myoid gonadal stromal tumour
317(2)
Sex cord stromal tumour NOS
319(2)
7 Tumours of the testicular adnexa
321(40)
Introduction
322(4)
Ovarian-type tumours of the collecting ducts and rete testis
Serous cystadenoma
326(1)
Serous tumour of borderline malignancy
327(2)
Serous cystadenocarcinoma
329(2)
Mucinous cystadenoma
331(2)
Mucinous borderline tumour
333(2)
Mucinous cystadenocarcinoma
335(2)
Endometrioid tumours
337(2)
Clear cell adenocarcinoma
339(1)
Brenner tumour
340(1)
Tumours of the collecting ducts and rete testis
Adenoma
341(1)
Adenocarcinoma
342(1)
Paratesticular mesothelial tumours
Adenomatoid tumour
343(3)
Well-differentiated papillary mesothelial tumour
346(2)
Mesothelioma
348(3)
Tumours of the epididymis
Cystadenoma
351(1)
Papillary cystadenoma
352(2)
Adenocarcinoma
354(2)
Squamous cell carcinoma
356(2)
Melanotic neuroectodermal tumour
358(3)
8 Tumours of the penis and scrotum
361(24)
Introduction
362(2)
Benign and precursor squamous lesions
Condyloma acuminatum
364(2)
Squamous cell carcinoma precursors, HPV-associated Penile intraepithelial neoplasia, HPV-associated
366(3)
Squamous cell carcinoma precursors, HPV-independent Differentiated penile intraepithelial neoplasia, HPV-independent
369(3)
Invasive epithelial tumours of the penis and scrotum Invasive squamous epithelial tumours
HPV-associated squamous cell carcinoma
372(3)
HPV-independent squamous cell carcinoma
375(3)
Squamous cell carcinoma NOS
378(2)
Other epithelial tumours
Penile adenosquamous and mucoepidermoid carci-nomas
380(1)
Extramammary Paget disease
381(2)
Other scrotal tumours
Basal cell carcinoma of the scrotum
383(2)
9 Neuroendocrine neoplasms
385(16)
Introduction
386(1)
Neuroendocrine tumours
Well-differentiated neuroendocrine tumour
387(2)
Neuroendocrine carcinomas
Small cell neuroendocrine carcinoma
389(3)
Large cell neuroendocrine carcinoma
392(2)
Mixed neuroendocrine neoplasms
394(3)
Paragangliomas
Paraganglioma
397(4)
10 Mesenchymal tumours
401(32)
Introduction
402(1)
Fibroblastic and myofibroblastic tumours
The angiofibroma family of tumours
403(2)
Solitary fibrous tumour
405(2)
Inflammatory myofibroblastic tumour
407(2)
Vascular tumours
Haemangioma
409(3)
Angiosarcoma
412(2)
Pericytic (perivascular) tumours
Glomus tumour
414(2)
Myointimoma
416(2)
Myopericytoma
418(1)
Extrarenal PEComa
419(2)
Smooth muscle tumours
Leiomyoma
421(2)
Leiomyosarcoma
423(2)
Skeletal muscle tumours
Rhabdomyosarcoma
425(2)
Tumours of uncertain differentiation
Synovial sarcoma
427(2)
Extrarenal rhabdoid tumour
429(2)
Desmoplastic small round cell tumour
431(2)
11 Haematolymphoid tumours
433(14)
Introduction
434(2)
Mature B-cell lymphomas
Extranodal marginal zone lymphoma of MALT
436(3)
Diffuse large B-cell lymphoma
439(3)
Plasmacytoma
442(3)
Histiocytic tumours
Juvenile xanthogranuloma
445(2)
12 Melanocytic lesions
447(4)
Mucosal melanoma
448(3)
13 Metastases in the genitourinary system
451(10)
Introduction
452(3)
Metastasis to the urinary tract
455(2)
Metastasis to the kidney
457(2)
Metastasis to the testis and paratestis
459(2)
14 Genetic tumour syndromes of the urinary and male genital tracts
461(36)
Introduction
462(2)
Von Hippel--Lindau syndrome
464(2)
Birt--Hogg--Dube syndrome
466(3)
Hereditary papillary renal carcinoma
469(2)
Hereditary leiomyomatosis and renal cell carcinoma syndrome
471(3)
Succinate dehydrogenase--deficient tumour syndromes
474(5)
BAP1 tumour predisposition syndrome
479(2)
Hereditary phaeochromocytoma--paraganglioma syndromes
481(3)
Tuberous sclerosis
484(3)
Genitourinary system and Lynch syndrome
487(3)
Hereditary tumour syndromes associated with homologous recombination pathway mutations
490(2)
Carney complex
492(2)
Peutz--Jeghers syndrome
494(3)
Contributors 497(6)
Declaration of interests 503(1)
IARC/WHO Committee for ICD-0 504(1)
Sources 505(6)
References 511(56)
Subject Index 567(9)
Previous volumes in the series 576