The increasing demand for innovative techniques arises from the lack of effective, and patient-friendly therapies for neurodegenerative disorders. With this objective in mind, the chapters of the book are structured to offer a thorough insight into recent advancements in utilizing the Zebrafish as a model for studying Parkinson's disease.
The increasing demand for innovative techniques arises from the lack of safe, effective, and patient-friendly therapies for neurodegenerative disorders. With this objective in mind, the chapters of the book are structured to offer a thorough insight into recent advancements in utilizing the zebrafish (ZF) as a model for studying Parkinson’s disease (PD). This book aims to present readers with a comprehensive understanding of the clinical application of the ZF model in treating PD, encompassing the latest developments, challenges, safety considerations, toxicity issues, regulatory aspects, future potential, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain stand to benefit from this resource.
Key Features
Provides a comparative perspective of the zebrafish–Parkinson’s disease modelHighlights the restrictions of available medicinesDescribes biochemical and histopathological characteristics, advantages, and disadvantages of this modelEmphasizes distinct facets of histopathologyPresents advances and developments of the future potential perspectives
SECTION-I: FROM AQUARIUM TO LAB: THE RISE OF ZEBRAFISH AS A MODEL
ORGANISM.
1. General Methods For Zebrafish Care.
2. Breeding of Zebrafish and
its life cycle.
3. Neurobehavioral assessment of Zebrafish.
4. Cellular and
Genetic Methods in Zebrafish.
5. Repeated blood sampling from an adult Danio
rerio.
6. Zebrafish Culture.
7. Calcium Imaging of Neuronal Activity in
Free-Swimming Larval Zebrafish.
8. Anesthesia, Analgesia, and Euthanasia of
the Laboratory Zebrafish.
9. Zebrafish Guidelines, Policies and Regulations
in Research. SECTION-II: ZEBRAFISH AS A MODEL OF PARKINSONS DISEASE.10. The
Role of Neurotransmitters in the Pathophysiology of Parkinson's Disease.
11.
Diagnosis and Biomarkers of PD.
12. Parkinson's Disease Models Pros and Cons.
13. Pharmacotherapy of PD and their limitations.
14. Induction and VALIDATION
OF ZF model of PD.
15. Zebra fish as a model for a novel Parkinsons disease
protective natural Product.
16. Zebrafish model for studying microbiome
associated Parkinsons Disease.
17. Transgenic zebrafish reporter lines for
in vivo studying of Parkinsons disease.
18. Interplay of neurodenegrative
disorders in zebrafish: unlocking the mystery.
19. Smart Capsule and Edible
Bird's Nest: Charting New Frontiers in Parkinsons Disease Defense-An
Experimental Protocol Perspective.
20. Zebrafish Model for Drug Discovery and
Screening.
Wael Mohamed Yousef Mohamed
BBCH (Egypt), MMSc (Egypt), MD/PhD (USA)
Dr. Mohamed, a Physician Neuroscientist, earned his PhD from PSU in the USA and currently holds the position of Associate Professor at IIUM Medical School in Malaysia. With an extensive background, Dr. Mohamed has been invited to deliver over 150 lectures both domestically and internationally. His contributions to Neuroscience/Psychiatry are notable, with the publication of more than 100 peer-reviewed papers, boasting an h-index of 20. Furthermore, Dr. Mohamed serves as an editor for Frontiers in Neurology and PLOS-ONE Journals, where he has contributed to various journal special issues on brain disorders. In the realm of book editing, he is actively involved with Springer, CRC, and Cambridge in the field of neuroscience. His research endeavors have attracted numerous grants from esteemed national and international organizations, including IBRO, ISN, MJF, STDF, FRGS, and INDO-ASEAN, amounting to a total research funding of half a million US$. Notably, he is the founder and chair of the AfrAbia-PD-Genomic Consortium.
