Zebrafish are becoming a fascinating new animal model for a variety of neurodegenerative diseases such as Parkinson’s disease, Alzheimer‘s disease, multiple sclerosis and other demyelinating diseases. Zebrafish produce a lot of embryos, grow quickly, are optically clear, and are receptive to genetic modification. They are therefore superior to current in vivo models in that they may be used to study neurological illnesses and create high-throughput drug screens. This book presents information on the use of zebrafish as a model organism in the modeling of neurodegenerative diseases with contributions from experts in the field. The general characteristics of zebrafish as a model organism are reviewed and neurogenesis and its regulation in zebrafish embryos is explained. Information about the use of zebrafish in NGS diseases such as Parkinson's, Alzheimer's and multiple sclerosis is presented. It is aimed to explain both toxin-induced and genetic models of separately.
Discussing the basic molecular mechanisms of neurodegenerative disorders and continuing the detailed exploration of zebrafish physiology, genetics, technologies including CRISPR/Cas9 genome editing, and analysis of zebrafish models highlighting their strengths in modelling disease progression and therapeutic testing.
Chapter 1: Main Molecular Mechanisms of Neurodegenerative Disorders.
Chapter 2: Molecular Markers of Neurodegenerative Disorders.
Chapter 3:
Pharmacotherapy of Neurodegenerative Diseases.
Chapter 4: Zebrafish Model of
Neurodegenerative Disorders.
Chapter 5: Zebrafish as a Model Organism for the
Investigation of Neurodegenerative Aspects of Autism Spectrum Disorders.
Chapter 6: Neurogenesis in the Zebrafish Olfactory Epithelium in Response to
Nuerotoxicity and Injury.
Chapter 7: Epigenetic Regulations during
Neurogenesis in Zebrafish.
Chapter 8: Proteomic Approaches on
Neurodegenerative Disease Models in Zebrafish.
Chapter 9: Zebrafish as a
Model for Functional Analyses of Alzheimer's Disease-Related Genes and Drug
Development.
Chapter 10: Perfluorinated Chemicals, Zebrafish, and
Neurodegenerative Disorders.Chapter 11: Effect of Myelination of
Neurodegeneration and Neurodegenerative Diseases in the Zebrafish
Model.Chapter 12: Zebrafish as a Model Organism to Evaluate the Neurotoxic
Effects of Endocrine Disruptive Chemicals.
Chapter 13: Using Zebrafish to
Explore the Brain-Gut Axis in Neurodegenerative Disorders.
Chapter 14:
Glyphosate Exposure and Neurological Outcomes in Zebrafish.
Chapter 15:
Zebrafish Model Organism to Investigate Pain in Neurodegenerative Diseases.
Chapter 16: Neurodegenerative Disease Modelling with CRISPR/CAS Systems in
Zebrafish.
Chapter 17: Zebrafish Genetic Models of Alzheimer's Disease.
Chapter 18: Neurodegenerative Effects of Boron and Other Elements on
Zebrafish and Zebrafish Embryos.
Chapter 19: Effects of Microplastics and
Nano-plastics on Neurodevelopment and Neurodegeneration in Zebrafish.
Chapter
20: Investigation of the Effects of Vitamins on Neurodegenerative Diseases
using Zebrafish as a Model Organism.Chapter 21: Usability of Zebrafish as a
Model Organism to Investigate the Relationship between Breast Milk and
Neurodegeneration.
Chapter 22: Antimicrobial Agents in Mouthwashes: Unveiling
Neurotoxic and Neurodegenerative Impacts through Zebrafish Models.
Dr. Ebru Emekli-Alturfan received her PhD in biochemistry from the University of Marmara in 2006 and was appointed as a professor in the Faculty of Dentistry at Marmara University, specifically within the Department of Basic Medical Sciences in 2016. Ebru Emekli-Alturfan leads a research group using Zebrafish as a model organism to investigate molecular mechanisms of neurodegeneration. Their research encompasses neurodegeneration, neurodevelopment, and its molecular regulation in vertebrate development. They use zebrafish as a main model system. To investigate the genetic foundation of human diseases, they work together with colleagues both within the Medical and Dental School and internationally to develop and implement in vivo models. Besides leading a research group, Ebru Emekli-Alturfan teaches medical biochemistry courses at Marmara University's Faculty of Dentistry and Institute of Health Sciences.
