KEY TOPICS:
Ig A Deficiency
The Role of Cellular Immunity in Protection against HIV Infection
Mouse Mammary Tumour Virus: Immunological Interplays between Virus and Host
The Transporter Associated with Antigen Processing
NF-kB in cytokine gene expression
NF-kB as a target for immunosuppressive and anti-inflammatory molecules
Key Features
* A Deficiency
* The Role of Cellular Immunity in Protection against HIV Infection
* Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host
* The Transporter Associated with Antigen Processing
* NF-kB in cytokine gene expression
* NF-kB as a target for immunosuppressive and anti-inflammatory molecules
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CONTRIBUTORS ix NF-IL6 and NF-kB in Cytokine Gene Regulation 1(46) SHIZUO AKIRA TADAMITSU KISHIMOTO I. Introduction 1(1) II. NF-IL6 1(10) III. NF-kB 11(5) IV. Protein-Protein interaction in Gene Regulation 16(9) V. Cytokine Gene Regulation 25(4) VI. Cytokine Induction in NF-IL6 Family Knockout Mice 29(1) VII. Cytokine Induction in NF-kB Knockout Mice 30(2) VIII. Conclusion 32(1) References 33(14) Transporter Associated with Antigen Processing 47(64) TIM ELLIOTT I. Introduction 47(9) II. ABC Transporters 56(2) III. Gene Structure of TAP and Its Regulation 58(3) IV. TAP Protein Structure 61(10) V. TAP Polymorphism 71(4) VI. Function of the TAP Complex 75(12) VII. TAP and MHC Class I Assembly 87(5) VIII. TAP in Disease 92(4) IX. Concluding Remarks 96(1) References 96(15) NF-kB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules 111(28) PATRICK A. BAEUERLE VIJAY R. BAICHWAL I. Introduction 111(7) II. Glucocorticoids and Other Steroid Hormones 118(2) III. Cyclosporin A and FK506 120(1) IV. Rapamycin 121(1) V. Salicylates 121(1) VI. Antioxidants and Inhibitors of Enzymes Generating Reactive Oxygen Intermediates 122(1) VII. Anti-TNF-XXX Antibodies and Gold Compounds in Treatment of Rheumatoid Arthritis 123(1) VIII. Immunosuppressive Activity of cAMP 124(1) IX. The Bacterial Metabolite Spergualin 125(1) X. The Fungal Metabolite Gliotoxin 126(1) XI. Viral Strategies to Control NF-kB 127(1) XII. Conclusion 128(4) References 132(7) Mouse Mammary Tumor Virus: Immunological interplays between Virus and Host 139(106) SANJIV A. LUTHER HANS ACHA-ORBEA I. Introduction 139(1) II. Mouse Mammary Tumor Virus 140(17) III. Structure of the SAg Protein 157(10) IV. Immune Response to MMTV 167(29) V. T and B Cell Response to Endogenous Mtv 196(12) VI. Comparison with Other SAgs 208(3) VII. Conclusions 211(1) References 212(33) IgA Deficiency 245(32) PETER D. BURROWS MAX D. COOPER I. Introduction 245(1) II. Clinical Manifestations of IgA Deficiency 246(2) III. IgA Structure, Production, and Function 248(3) IV. IgA Deficiency Viewed in the Context of the Genesis of IgA-Producing Cells 251(5) V. Relationship of IgAD with Common Variable Immunodeficiency 256(1) VI. Genetic Susceptibility for IgAD and CVID 256(4) VII. Pathogenesis of IgA Deficiency 260(3) VIII. Conclusions 263(1) References 263(14) Role of Cellular Immunity in Protection against HIV Infection 277(70) SARAH ROWLAND-JONES RUSUNG TAN ANDREW MCMICHAEL I. Introduction 277(1) II. Cellular Immunity in the Control of Other Viruses 278(2) III. CTL Effector Mechanisms 280(4) IV. HLA and HIV Infection 284(2) V. The Nature of HIV-Specific CTLs 286(1) VI. Measurement of HIV-Specific CTLs 287(3) VII. Role of HIV-Specific CTLs in the Natural History of HIV Infection 290(21) VIII. Does HIV Escape from the CTL Response? 311(6) IX. Therapeutic Implications of the Importance of HIV-Specific CTLs 317(5) X. Conclusions 322(1) References 323(24) High Endothelial Venules: Lymphocyte Traffic Control and Controlled Traffic 347(50) GEORG KRAAL REINA E. MEBIUS I. Introduction 347(1) II. Structure of High Endothelial Venules 348(2) III. Role of HEVs and Lymphocyte Migration 350(1) IV. In Vitro HEV Binding Assay 351(1) V. Molecules Determining HEV-Lymphocyte Interactions 352(1) VI. L Selectin 352(6) VII. Integrins and Their Role in Lymphocyte-HEV Interactions 358(1) VIII. CD44 and Lymphocyte Homing 359(1) IX. Homing Receptor Ligands on High Endothelial Cells 360(5) X. Additional Molecules on High Endothelial Venules Involved in Lymphocyte Migration 365(1) XI. Adhesion and Extravasation 365(4) XII. Adhesion Cascade and Specificity of Lymphocyte Homing 369(3) XIII. Regulation of the Unique Features of the High Endothelial Venule 372(7) XIV. Concluding Remarks 379(1) References 380(17) INDEX 397(10) CONTENTS OF RECENT VOLUMES 407
