List of Contributors |
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xv | |
Preface |
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xix | |
Acknowledgments |
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xxi | |
Part 1: Analysis In Nutrition Research |
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Chapter 1 Design of Observational Nutrition Studies |
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3 | (20) |
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1.1 Introduction to Observational Nutrition Studies |
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3 | (2) |
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1.2 Ecological Nutrition Studies |
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5 | (1) |
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5 | (1) |
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5 | (1) |
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1.2.3 Example of Ecological Study on Diet and Cancer |
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6 | (1) |
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1.3 Cross-Sectional Nutrition Studies |
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6 | (6) |
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6 | (2) |
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8 | (2) |
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10 | (1) |
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1.3.4 Example of the National Health and Nutrition Examination Survey |
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11 | (1) |
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1.4 Case-Control Nutrition Studies |
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12 | (3) |
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12 | (1) |
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12 | (2) |
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14 | (1) |
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1.4.4 An Example in the Study of Hodgkin Lymphoma |
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15 | (1) |
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1.5 Cohort Nutrition Studies |
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15 | (4) |
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15 | (1) |
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16 | (1) |
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17 | (1) |
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1.5.4 Example of the Nurses' Health Study |
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18 | (1) |
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19 | (4) |
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Chapter 2 Study Design in Experimental Settings |
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23 | (20) |
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24 | (1) |
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24 | (5) |
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25 | (1) |
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25 | (2) |
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27 | (2) |
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2.3 Planning a Dietary Intervention |
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29 | (8) |
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2.3.1 Definition of the Research Question, Hypothesis, and Main Objectives |
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30 | (1) |
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2.3.2 Primary and Secondary Outcomes |
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30 | (1) |
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30 | (5) |
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2.3.4 Selection of the Study Design |
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35 | (1) |
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35 | (1) |
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35 | (2) |
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2.4 Conducting the Dietary Intervention |
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37 | (2) |
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2.4.1 Recruitment and Screening of Participants |
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37 | (1) |
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2.4.2 Compliance of Participants |
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37 | (1) |
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38 | (1) |
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2.4.4 Statistical Analysis |
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39 | (1) |
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39 | (1) |
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39 | (2) |
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41 | (2) |
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Chapter 3 Collection and Management of Dietary Data |
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43 | (32) |
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44 | (1) |
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45 | (12) |
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3.2.1 Methods for Collecting Dietary Information |
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45 | (9) |
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54 | (1) |
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3.2.3 Types of Collected Dietary Information |
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54 | (3) |
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3.3 Data Management and Dietary Analysis |
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57 | (7) |
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57 | (1) |
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3.3.2 Estimations of Nutrient Content of Foods |
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58 | (2) |
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3.3.3 Configuration and Labeling of Datasets |
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60 | (1) |
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3.3.4 Handling of Food Group Data |
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61 | (3) |
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64 | (3) |
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3.4.1 Validation, Reproducibility, Calibration, and Biomarkers |
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64 | (1) |
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3.4.2 Measurement Error, Misreporting, and Outliers |
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65 | (2) |
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67 | (1) |
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67 | (8) |
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Chapter 4 Dietary Pattern Analysis |
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75 | (28) |
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76 | (1) |
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4.2 Types of Dietary Pattern Analysis |
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77 | (1) |
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4.3 A Priori Dietary Pattern Analysis |
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77 | (9) |
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77 | (2) |
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4.3.2 Key Aspects for the Development of a Dietary Score |
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79 | (2) |
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4.3.3 Dietary Assessment Methodologies for a Priori Dietary Pattern Analysis |
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81 | (1) |
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4.3.4 Evaluation of the Quality of an a Priori Dietary Pattern |
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81 | (1) |
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4.3.5 Examples of a Priori Dietary Patterns |
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82 | (4) |
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4.4 A Posteriori Dietary Pattern Analysis |
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86 | (8) |
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86 | (1) |
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86 | (3) |
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4.4.3 Examples of Factor Analysis |
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89 | (1) |
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89 | (2) |
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4.4.5 Examples of Cluster Analysis |
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91 | (1) |
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4.4.6 Comparison of Factor and Cluster Analysis |
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91 | (1) |
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4.4.7 Reproducibility and Validity of a Posteriori Dietary Pattern Analysis |
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92 | (2) |
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4.5 Hybrid Dietary Pattern Analysis |
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94 | (1) |
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94 | (1) |
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4.5.2 Examples of Hybrid Dietary Pattern Analysis |
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94 | (1) |
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4.6 Challenges in Dietary Pattern Analysis |
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95 | (1) |
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96 | (7) |
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Chapter 5 Statistical Analysis of Retrospective Health and Nutrition Data |
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103 | (42) |
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104 | (1) |
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105 | (1) |
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5.3 Descriptive Statistics |
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106 | (5) |
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107 | (1) |
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107 | (4) |
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5.4 Assessment of Normality |
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111 | (2) |
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113 | (2) |
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5.6 Pearson Chi-Square Test |
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115 | (2) |
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5.7 Statistical Tests for Comparison of Means |
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117 | (3) |
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117 | (1) |
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5.7.2 One-Way Analysis of Variance |
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118 | (2) |
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5.8 Pearson Correlation Coefficient |
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120 | (1) |
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121 | (1) |
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5.10 Linear Regression Analysis |
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122 | (13) |
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5.10.1 Simple Linear Regression |
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122 | (8) |
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5.10.2 Multiple Linear Regression Analysis |
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130 | (5) |
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5.11 Logistic Regression Analysis |
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135 | (5) |
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135 | (1) |
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5.11.2 Simple Binary Logistic Regression Analysis |
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136 | (1) |
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5.11.3 Multiple Binary Logistic Regression Analysis |
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137 | (1) |
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138 | (2) |
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140 | (5) |
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Chapter 6 Statistical Analysis of Prospective Health and Nutrition Data |
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145 | (18) |
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145 | (1) |
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6.2 Descriptive Statistics |
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146 | (1) |
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6.3 Measures to Calculate the Occurrence of a Health Outcome |
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146 | (3) |
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146 | (2) |
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148 | (1) |
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149 | (10) |
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149 | (1) |
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6.4.2 Kaplan-Meier Analysis |
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150 | (2) |
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152 | (3) |
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6.4.4 Cox Regression Analysis |
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155 | (4) |
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159 | (4) |
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Chapter 7 Meta-Analysis of Nutrition Studies |
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163 | (34) |
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164 | (1) |
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7.2 Methodology of Meta-Analysis in Nutrition Research |
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165 | (5) |
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7.2.1 Defining the Search Strategy |
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166 | (3) |
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7.2.2 Study Selection Procedure |
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169 | (1) |
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169 | (1) |
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170 | (1) |
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7.3 Statistical Methodologies Applied in Meta-Analysis of Nutrition Studies |
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170 | (8) |
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7.3.1 Statistical Measures of Effect Included in Meta-Analysis |
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171 | (2) |
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7.3.2 Choice of Meta-Analytical Method |
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173 | (2) |
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7.3.3 Statistical Heterogeneity |
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175 | (2) |
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7.3.4 Small-Study Effects |
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177 | (1) |
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7.3.5 Software for Meta-Analysis |
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178 | (1) |
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7.4 Presentation and Interpretation of Results |
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178 | (9) |
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179 | (1) |
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7.4.2 Study Characteristics |
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179 | (1) |
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179 | (3) |
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7.4.4 Assessing Heterogeneity |
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182 | (2) |
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184 | (1) |
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184 | (3) |
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7.5 Limitations and Biases |
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187 | (4) |
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189 | (2) |
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191 | (6) |
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Chapter 8 Principles of Research Publication |
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197 | (36) |
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198 | (1) |
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8.2 Citation Impact and Metrics |
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198 | (2) |
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200 | (7) |
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200 | (3) |
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203 | (1) |
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204 | (1) |
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8.3.4 Methods and Results |
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205 | (2) |
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8.3.5 Discussion and Conclusions |
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207 | (1) |
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8.4 Web Tools for Writing |
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207 | (4) |
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208 | (1) |
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208 | (2) |
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210 | (1) |
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211 | (1) |
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8.5 Reporting Data and Analysis |
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211 | (7) |
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8.5.1 Dietary Evaluation and Analysis |
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212 | (1) |
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8.5.2 Statistical Analysis |
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212 | (1) |
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213 | (4) |
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217 | (1) |
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218 | (2) |
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8.6.1 Selecting the Journal |
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218 | (1) |
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8.6.2 A Winning Cover Letter |
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218 | (2) |
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8.7 Authorship Criteria and Acknowledgments |
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220 | (3) |
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8.8 Strengthening the Reporting of Observational Studies in Epidemiology and Consolidated Standards of Reporting Trials Statements |
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223 | (1) |
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224 | (1) |
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225 | (8) |
Part 2: Challenges In Nutrition Science |
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Chapter 9 Mediterranean Diet: A Health-Protective Dietary Pattern for Modern Times |
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233 | (26) |
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234 | (1) |
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9.2 Scientific Definition of Mediterranean Diet |
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234 | (1) |
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9.2.1 Historical Overview |
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234 | (1) |
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9.2.2 The Traditional Mediterranean Diet |
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235 | (1) |
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9.3 Evidence on Health Benefits of the Mediterranean Diet |
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235 | (4) |
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9.3.1 Cardiovascular Diseases |
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235 | (1) |
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236 | (1) |
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237 | (1) |
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9.3.4 Nonalcoholic Fatty Liver Disease |
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237 | (1) |
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9.3.5 Rheumatoid Arthritis |
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238 | (1) |
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238 | (1) |
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9.4 Food Components of Mediterranean Diet |
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239 | (5) |
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9.4.1 Fish and Marine Omega-3 Polyunsaturated Fats |
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239 | (1) |
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240 | (1) |
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241 | (1) |
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9.4.4 Fruits and Vegetables |
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241 | (1) |
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242 | (1) |
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243 | (1) |
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244 | (1) |
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9.5 Mediterranean Diet Adherence in Modern Times |
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244 | (2) |
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9.5.1 Level of Adherence in Modern Populations |
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244 | (2) |
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9.5.2 Challenges of Adhering to the Mediterranean Diet |
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246 | (1) |
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9.6 Shifting to the Mediterranean Diet in the Modern Context |
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246 | (4) |
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9.6.1 Updated Mediterranean Diet Recommendations |
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246 | (2) |
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9.6.2 Focus on Sustainability |
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248 | (2) |
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250 | (1) |
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250 | (9) |
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Chapter 10 Polyphenol-Rich Diets in Cardiovascular Disease Prevention |
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259 | (40) |
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260 | (1) |
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10.2 Polyphenols: Classes, Structures, and Chemical Properties |
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261 | (1) |
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10.3 Polyphenols in Human Diet |
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261 | (6) |
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10.3.1 Major Dietary Sources |
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261 | (3) |
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10.3.2 Analytical Techniques to Determine Phenolic Contents |
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264 | (1) |
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10.3.3 Estimation of Polyphenol Intakes in Human Populations |
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265 | (2) |
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10.4 Dietary Polyphenols and Cardiovascular Disease |
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267 | (20) |
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10.4.1 Cardiovascular Disease Incidence and Mortality: Evidence From Epidemiological Studies |
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267 | (5) |
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10.4.2 Cardiovascular Disease Biomarkers: Evidence From Epidemiological Studies |
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272 | (2) |
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10.4.3 Cardiovascular Disease Biomarkers: Evidence From Interventional Studies |
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274 | (6) |
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10.4.4 Biological Functions of Polyphenols in Cardiovascular Disease Prevention |
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280 | (7) |
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10.5 Challenges in Polyphenol Research |
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287 | (1) |
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288 | (1) |
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289 | (9) |
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298 | (1) |
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Chapter 11 Hydration and Health |
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299 | (22) |
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300 | (1) |
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11.1.1 Terminology and Measurement of Hydration Status |
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300 | (1) |
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11.2 Hydration and Kidney Health |
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301 | (3) |
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301 | (1) |
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11.2.2 Hydration and Kidney Function |
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302 | (1) |
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11.2.3 Arginine Vasopressin and Chronic Kidney Disease |
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302 | (1) |
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11.2.4 Mesoamerican Nephropathy |
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303 | (1) |
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11.2.5 Other Kidney Diseases |
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303 | (1) |
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11.2.6 Water Intake Intervention in Chronic Kidney Disease |
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304 | (1) |
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11.3 Hydration and Glucose Regulation |
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304 | (2) |
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304 | (1) |
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11.3.2 Implications of Arginine Vasopressin in Glucose Regulation |
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304 | (2) |
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11.3.3 Other Considerations in Hydration and Glucose Regulation |
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306 | (1) |
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11.4 Implications of Fluid Balance and Obesity |
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306 | (3) |
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306 | (1) |
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11.4.2 Sugar-Sweetened Beverages |
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307 | (1) |
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11.4.3 Hydration Status and Obesity |
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307 | (2) |
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11.5 Hydration and Cardiovascular Health |
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309 | (1) |
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309 | (1) |
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11.5.2 Cardiovascular Effects |
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310 | (1) |
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11.6 Hydration and Oxidative Stress |
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310 | (1) |
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310 | (1) |
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11.6.2 Implications of Poor Fluid Balance |
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311 | (1) |
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11.7 Hydration and Risk of Bladder Cancer |
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311 | (1) |
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311 | (1) |
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312 | (1) |
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312 | (1) |
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313 | (8) |
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Chapter 12 Diet, Healthy Aging, and Cognitive Function |
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321 | (16) |
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321 | (1) |
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12.2 Definition and Epidemiology of Cognitive Decline |
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322 | (1) |
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12.3 Bioactive Components of a Healthy Diet and Cognitive Decline |
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323 | (3) |
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12.3.1 Antioxidant Vitamins |
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323 | (1) |
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323 | (1) |
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12.3.3 Vitamins of the B Complex |
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324 | (1) |
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12.3.4 Unsaturated Fatty Acids |
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325 | (1) |
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326 | (1) |
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12.4 Dietary Patterns and Cognitive Decline |
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326 | (2) |
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12.4.1 The Mediterranean Diet |
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327 | (1) |
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12.4.2 The DASH Diet Plan |
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327 | (1) |
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327 | (1) |
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12.5 Modern Approaches in the Study of Diet and Cognitive Health |
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328 | (1) |
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329 | (1) |
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330 | (1) |
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330 | (7) |
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Chapter 13 Diet and Bone Health |
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337 | (18) |
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338 | (1) |
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13.2 Brief Overview of Bone Physiology |
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338 | (1) |
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13.2.1 Overview of Bone Structure and Function |
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338 | (1) |
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13.2.2 Bone Modeling and Remodeling |
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338 | (1) |
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13.2.3 Assessment of Bone Outcomes in Research |
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339 | (1) |
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13.3 Calcium and Vitamin D |
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339 | (5) |
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13.3.1 Calcium and Bone, an Overview |
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339 | (1) |
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13.3.2 Vitamin D and Bone, an Overview |
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340 | (1) |
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341 | (1) |
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342 | (1) |
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343 | (1) |
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343 | (1) |
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343 | (1) |
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13.4 Life Course Perspective on Nutrition and Bone |
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344 | (7) |
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13.4.1 Osteoporosis: Burden and Epidemiology |
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344 | (1) |
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13.4.2 Etiology of Osteoporosis and Role of Diet |
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344 | (1) |
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13.4.3 Maternal Nutrition and Bone Outcomes |
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345 | (1) |
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13.4.4 Childhood and Adolescence |
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346 | (2) |
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13.4.5 Bone Health in the Older Adult: Menopause and Beyond |
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348 | (3) |
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13.5 Challenges in Nutrition and Bone Research |
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351 | (1) |
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352 | (3) |
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Chapter 14 Diet and Lung Health |
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355 | (28) |
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Konstantinos I. Gourgoulianis |
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356 | (1) |
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14.2 Diet and Pulmonary Function |
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357 | (1) |
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357 | (3) |
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358 | (1) |
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358 | (1) |
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359 | (1) |
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359 | (1) |
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359 | (1) |
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360 | (1) |
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14.4 Diet and Chronic Obstructive Pulmonary Disease |
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360 | (2) |
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360 | (1) |
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360 | (1) |
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361 | (1) |
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361 | (1) |
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14.4.5 Probiotics and Dietary Fibers |
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361 | (1) |
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362 | (1) |
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14.5 Diet and Lower Respiratory Tract Infections |
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362 | (3) |
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363 | (1) |
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364 | (1) |
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364 | (1) |
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14.5.4 Probiotics-Prebiotics |
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364 | (1) |
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365 | (1) |
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14.6 Diet and Tuberculosis |
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365 | (2) |
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365 | (1) |
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365 | (1) |
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366 | (1) |
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366 | (1) |
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366 | (1) |
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366 | (1) |
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14.7 Diet and Lung Cancer |
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367 | (2) |
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367 | (1) |
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367 | (1) |
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368 | (1) |
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368 | (1) |
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368 | (1) |
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14.8 Diet and Cystic Fibrosis |
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369 | (1) |
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369 | (1) |
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369 | (1) |
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370 | (1) |
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370 | (1) |
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370 | (1) |
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14.9 Diet and Interstitial Lung Diseases |
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370 | (1) |
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14.10 Maternal Diet in Early Life and Lung Health |
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371 | (1) |
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371 | (1) |
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371 | (1) |
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372 | (1) |
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372 | (1) |
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14.11 Challenges in Diet and Lung Health Research |
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372 | (1) |
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373 | (8) |
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381 | (2) |
Index |
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383 | |