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Biological Membrane Ion Channels: Dynamics, Structure, and Applications 2007 [Kõva köide]

  • Formaat: Hardback, 658 pages, kõrgus x laius: 234x156 mm, kaal: 2460 g, 168 Illustrations, black and white; XIV, 658 p. 168 illus., 1 Hardback
  • Sari: Biological and Medical Physics, Biomedical Engineering
  • Ilmumisaeg: 17-Nov-2006
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 0387333231
  • ISBN-13: 9780387333236
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  • Formaat: Hardback, 658 pages, kõrgus x laius: 234x156 mm, kaal: 2460 g, 168 Illustrations, black and white; XIV, 658 p. 168 illus., 1 Hardback
  • Sari: Biological and Medical Physics, Biomedical Engineering
  • Ilmumisaeg: 17-Nov-2006
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 0387333231
  • ISBN-13: 9780387333236
Teised raamatud teemal:
Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Key FeaturesPresents the latest information on the molecular mechanisms of ion permeation through membrane ion channelsUses schematic diagrams to illustrate important concepts in biophysicsContains a CD-ROM with computer programs used for making theoretical calculations, as well as video animations illustrating various features of ion channelsWritten by leading researchers in the area of ion channel investigations

This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Preface v
List of Contributors xi
Part I. Introduction
1 Ion Channels, from Fantasy to Fact in Fifty Years
3(30)
Peter C. Jordan
Part II. Specific Channel Types
2 Gramicidin Channels: Versatile Tools
33(48)
Olaf S. Andersen, Roger E. Koeppe II, and Benoit Roux
3 Voltage-Gated Ion Channels
81(38)
Francisco Bezanilla
4 Voltage-Gated Potassium Channels
119(52)
Stephen J. Korn and Josef G. Trapani
5 BKca-Channel Structure and Function
171(48)
Daniel H. Cox
6 Voltage-Gated Sodium Channels
219(22)
Dorothy A. Hanck and Harry A. Fozzard
7 Calcium Channels
241(60)
Ben Corry and Livia Hool
8 Chloride Transporting CLC Proteins
301(34)
Michael Pusch
9 Ligand-Gated Ion Channels: Permeation and Activation
335(34)
Joseph W. Lynch and Peter H. Barry
10 Mechanosensitive Channels
369(30)
Boris Martinac
11 TRP Channels
399(26)
Thomas Voets, Grzegorz Owsianik, and Bernd Nilius
12 Ion Channels in Epithelial Cells
425(24)
Lawrence G. Palmer
Part III. Theoretical Approaches
13 Poisson–Nernst–Planck Theory of Ion Permeation Through Biological Channels
449(36)
Rob D. Coalson and Maria G. Kurnikova
14 A Mesoscopic–Microscopic Perspective on Ion Channel Permeation Energetics: The Semi-Microscopic Approach
485(22)
Peter C. Jordan
15 Brownian Dynamics Simulation for Ion Channel Permeation
507(38)
Shin-Ho Chung and Vikram Krishnamurthy
16 Molecular Dynamics Simulation Approaches to K Channels
545(26)
Alessandro Grottesi, Shozeb Haider, and Mark S.P. Sansom
Part IV. Emerging Technologies
17 Patch-Clamp Technologies for Ion Channel Research
571(24)
Fred J. Sigworth and Kathryn G. Klemic
18 Gated Ion Channel-Based Biosensor Device
595(28)
Frances Separovic and Bruce A. Cornell
19 Signal Processing Based on Hidden Markov Models for Extracting Small Channel Currents
623(28)
Vikram Krishnamurthy and Shin-Ho Chung
Index 651