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E-raamat: Biological Membrane Ion Channels: Dynamics, Structure, and Applications

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Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology.This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.The book includes a CD-ROM with computer programs used for making theoretical calculations, as well as video animations illustrating various features of ion channels.

This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Ion Channels, from Fantasy to Fact in Fifty Years1.- Specific Channel
Types.- Gramicidin Channels: Versatile Tools.- Voltage-Gated Ion Channels.-
Voltage-Gated Potassium Channels.- BKCa-Channel Structure and Function.-
Voltage-Gated Sodium Channels.- Calcium Channels.- Chloride Transporting CLC
Proteins1.- Ligand-Gated Ion Channels: Permeation and Activation1.-
Mechanosensitive Channels.- TRP Channels.- Ion Channels in Epithelial Cells.-
Theoretical Approaches.- PoissonNernstPlanck Theory of Ion Permeation
Through Biological Channels.- A MesoscopicMicroscopic Perspective on Ion
Channel Permeation Energetics: The Semi-Microscopic Approach1.- Brownian
Dynamics: Simulation for Ion Channel Permeation1.- Molecular Dynamics
Simulation Approaches to K Channels.- Emerging Technologies.- Patch-Clamp
Technologies for Ion Channel Research.- Gated Ion Channel-Based Biosensor
Device.- Signal Processing Based on Hidden Markov Models for Extracting Small
Channel Currents.