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Biology, Computing, and the History of Molecular Sequencing: From Proteins to DNA, 1945-2000 [Kõva köide]

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Püsilink: https://www.kriso.ee/db/9780230250321.html
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Sequencing is often associated with the Human Genome Project and celebrated achievements concerning the DNA molecule. However, the history of this practice comprises not only academic biology, but also the world of computer-assisted information management. The book uncovers this history, qualifying the hype and expectations around genomics.

Arvustused

"Overall, this book provides a detailed time line of the events from the earliest methodologies to the metagenomic sequencing standard of today, and is a useful resource for anyone interested in the historical angle of DNA sequencing. Highly recommended." - M.C. Pavao, Worcester State College, Choice





"...an invaluable, possibly even essential, addition to the bookshelf of anyone wishing to understand modern biology in all its facets...The author has done a masterful job of integrating information about the way in which different aspects of computer science...have contributed to the development of sequencing." - Neeraja Sankaran, British Journal for the History of Science, 46: 544





"...a revised dissertation, grounded in a remarkable variety of primary sources including corporate records and oral history interviews." - Ruth Schwatz Cowan, American Historical Review, June 2013: 827





"...a timely and informative history of molecular sequencing ... Overall, Garcia-Sancho's book provides a highly readable and insightful analysis of the history of molecular sequencing, one that should be appreciated for its broad synthesis of existing scholarship and its extensive use of historical documents.." - Doogab Yi, History and Philosophy of the Life Sciences





"Supported by an impressive archival and oral research, and by a thorough revision of the secondary literature of the field, García-Sancho´s book is a celebration of what the history of recentand contemporary science can achieve, and for years to come it will remain as an obliged reference not only for historians of science, but for sociologists and all those interested in the detailed development of the industrialized-information society." - Edna Suarez-Diaz, Dynamis

List of Figures
x
Acknowledgements xii
Introduction: An Historical Approach to Sequencing 1(16)
A long history writ short
3(6)
A short history writ long
9(2)
Sequencing as a form of work
11(3)
Structure and methodology
14(3)
Part I Emergence: Frederick Sanger's Pioneering Techniques (1943-1977)
17(48)
1 The Sequence of Insulin and the Configuration of a New Biochemical Form of Work (1943-1962)
21(18)
1.1 Chibnall, Fischer and the chemical analysis of proteins
22(2)
1.2 Periodical or undetermined chains?
24(1)
1.3 Determining an unpredictable `sequence'
25(4)
1.4 An emerging form of work
29(3)
1.5 Absorbing (bio)chemical practices
32(2)
1.6 Expansion and the convergence with molecular biology
34(5)
2 From Chemical Degradation to Biological Replication (1962-1977)
39(26)
2.1 The move to a new centre
41(3)
2.2 Molecular biology and Sanger's professional identity
44(2)
2.3 Protein synthesis and the transition to nucleic acids
46(3)
2.4 The development of new techniques
49(4)
2.5 The insufficiency of a technological explanation
53(5)
2.6 Sequencing and the move towards biology
58(4)
2.7 Rival attempts and the idea of `elegance'
62(3)
Part II Mechanisation - 1: Computing and the Automation of Sequence Reconstruction (1962-1987)
65(50)
3 Sequencing Software and the Shift in the Practice of Computation
71(20)
3.1 Reading-off, puzzle-solving and the first computer program
72(2)
3.2 The crystallographers and the difference between sequence and structure
74(2)
3.3 Sequence determination and the changing use of computers
76(4)
3.4 Biological computing and Cambridge molecular biology
80(3)
3.5 Sequencing software and the difficult formation of a community
83(8)
4 Sequence Databases and the Emergence of `Information Engineers'
91(24)
4.1 The European workshop on sequencing and computers
92(4)
4.2 Information engineers and the problem of interdisciplinarity
96(4)
4.3 Data management practices and earlier biological collections
100(4)
4.4 Sequencing algorithms, database technologies and operating systems
104(6)
4.5 Hierarchy, biocomputing and cooperation with biologists
110(5)
Part III Mechanisation - 2: The Sequencer and the Automation of Sequence Construction (1980-2000)
115(54)
5 A New Approach to Sequencing at Caltech
119(25)
5.1 Contrasting groups, different personas
119(7)
5.2 Institutional differences v national stereotypes
126(5)
5.3 Research values and attitudes towards automation
131(3)
5.4 Out of the `autoradiograph world'
134(2)
5.5 String decoding and the computer as model
136(5)
5.6 Rival automation attempts
141(3)
6 The Commercialisation of the DNA Sequencer
144(25)
6.1 Academic-industrial complexes
146(3)
6.2 ABI as an instrument-making firm
149(3)
6.3 Managerial practices and the sequencer as information technology
152(2)
6.4 The reception of the sequencer and the different standards of sequencing
154(6)
6.5 Thermal cyclers and the introduction of PCR
160(3)
6.6 Genomics and the organisation of large-scale sequencing
163(6)
Conclusions: A Long History of Practices 169(9)
Appendix I Oral Histories 178(1)
Appendix II Archival Sources 179(1)
Notes 180(23)
Bibliography 203(28)
General Index 231(6)
Index of Persons-Institutions 237
Miguel Garcia-Sancho obtained his Ph.D. at Imperial College London, UK, and has worked at the University of Manchester and Spanish National Research Council (CSIC). He is currently a Chancellor's Fellow at the Department of Science, Technology and Innovation Studies of the University of Edinburgh. His interests lay in the history and social studies of twentieth century biomedicine, as well as science communication and free-lance scientific journalism.