Series Preface |
|
vii | |
Preface |
|
ix | |
Series Editor |
|
xi | |
Acknowledgments |
|
xiii | |
Contributors |
|
xv | |
|
1 Amperometric Biosensors in Food Processing, Safety, and Quality Control |
|
|
1 | (52) |
|
|
|
|
2 | (1) |
|
1.2 Amperometric Biosensors |
|
|
2 | (7) |
|
1.2.1 Principles of Amperometric Transduction |
|
|
3 | (1) |
|
1.2.2 Amperometric Enzyme Electrode |
|
|
3 | (2) |
|
1.2.3 Mediated Amperometric Enzyme Electrodes |
|
|
5 | (2) |
|
1.2.4 Amperometric Enzyme Electrodes with Nondiffusing Mediators |
|
|
7 | (1) |
|
1.2.5 Multienzyme Electrodes |
|
|
7 | (2) |
|
1.3 Basic Construction and Measurement Principles |
|
|
9 | (4) |
|
1.4 The Interference-Free Biosensors |
|
|
13 | (6) |
|
1.5 Applications of Amperometric Biosensors |
|
|
19 | (11) |
|
1.5.1 Determination of Food Components |
|
|
20 | (1) |
|
|
20 | (3) |
|
|
23 | (1) |
|
|
24 | (1) |
|
|
24 | (1) |
|
|
25 | (1) |
|
1.5.1.6 Other Food Components |
|
|
26 | (1) |
|
1.5.2 Determination of Food Contaminants |
|
|
27 | (1) |
|
|
27 | (1) |
|
1.5.2.2 Foodborne Pathogens |
|
|
27 | (1) |
|
|
28 | (1) |
|
1.5.2.4 Other Contaminants |
|
|
29 | (1) |
|
1.5.3 Determination of Food Additives |
|
|
29 | (1) |
|
1.6 Commercial Availability of Amperometric Biosensors for Food |
|
|
30 | (8) |
|
|
38 | (1) |
|
|
39 | (14) |
|
2 Basic Principles of Optical Biosensors in Food Engineering |
|
|
53 | (18) |
|
|
|
|
53 | (1) |
|
|
54 | (1) |
|
2.3 Principles of Optical Detection |
|
|
55 | (1) |
|
2.4 Types of Optical Biosensors |
|
|
55 | (8) |
|
2.4.1 Direct Optical Detection |
|
|
55 | (1) |
|
2.4.1.1 Reflectometric Detection |
|
|
55 | (1) |
|
2.4.1.2 Reflectometric Interference Spectroscopy |
|
|
56 | (1) |
|
|
56 | (1) |
|
2.4.1.4 Evanescent Field Techniques |
|
|
56 | (2) |
|
2.4.1.5 Mach-Zehnder Interferometer |
|
|
58 | (1) |
|
2.4.1.6 Young Interferometer |
|
|
58 | (1) |
|
2.4.1.7 Resonant Mirror Sensor |
|
|
59 | (1) |
|
2.4.1.8 Surface Plasmon Resonance |
|
|
59 | (2) |
|
|
61 | (1) |
|
2.4.2 Labeled Systems Detection |
|
|
61 | (1) |
|
2.4.3 Fiber-Optic Biosensors |
|
|
62 | (1) |
|
2.5 Optical Biosensors for Food Quality and Food Safety |
|
|
63 | (3) |
|
|
66 | (1) |
|
|
66 | (5) |
|
3 Mass Sensitive Biosensors Principles and Applications in Food |
|
|
71 | (18) |
|
|
|
71 | (2) |
|
3.2 Detection Scheme of Quartz Crystal Microbalance (QCM) |
|
|
73 | (1) |
|
|
74 | (1) |
|
3.4 Applications of QCM in Food Analysis |
|
|
75 | (1) |
|
3.5 QCM Immunosensor for Histamine |
|
|
76 | (3) |
|
3.5.1 Modification of Quartz Crystal Surfaces |
|
|
76 | (1) |
|
3.5.1.1 Chemical Treatment |
|
|
76 | (1) |
|
3.5.1.2 Plasma Polymerization |
|
|
77 | (2) |
|
3.6 Activation of Modified Quartz Crystal Surfaces |
|
|
79 | (1) |
|
3.6.1 Functionalization of the Surfaces by Glutaraldehyde |
|
|
79 | (1) |
|
3.6.2 Treatment with EDC/NHS |
|
|
80 | (1) |
|
3.7 Biomolecule Immobilization |
|
|
80 | (1) |
|
3.8 Analysis of Toxins in Food |
|
|
81 | (2) |
|
3.8.1 Determination of Histamine |
|
|
81 | (1) |
|
3.8.1.1 Calibration of the Histamine Immunosensor |
|
|
82 | (1) |
|
3.8.1.2 Performance of the Histamine Immunosensor |
|
|
82 | (1) |
|
|
83 | (1) |
|
|
83 | (6) |
|
4 Biosensing for Food Safety |
|
|
89 | (34) |
|
|
|
|
89 | (8) |
|
4.1.1 Food Residues and Pathogens in Food Safety |
|
|
89 | (2) |
|
4.1.2 Food Pathogen Detection by Culture and Rapid Methods |
|
|
91 | (2) |
|
4.1.3 Pesticide and Drug Residue Detection Methods |
|
|
93 | (4) |
|
4.2 Biosensing: A Novel Strategy for Food Safety |
|
|
97 | (7) |
|
4.2.1 Transducing Features in Electrochemical Biosensors |
|
|
98 | (2) |
|
4.2.2 Immobilization Strategies in Electrochemical Biosensors for Food Safety |
|
|
100 | (2) |
|
4.2.3 Electrochemical Detection Strategies in Electrochemical Biosensors for Food Safety |
|
|
102 | (2) |
|
4.3 Electrochemical Immunosensing for Food Safety |
|
|
104 | (4) |
|
4.4 Electrochemical Genosensing for Food Safety |
|
|
108 | (6) |
|
4.5 Electrochemical Biosensing Approaches Combining Both Immunological and Genetic Information for Food Safety |
|
|
114 | (2) |
|
|
116 | (1) |
|
|
117 | (6) |
|
5 Electrochemical DNA Biosensors in Food Safety |
|
|
123 | (12) |
|
|
|
|
|
123 | (1) |
|
|
124 | (6) |
|
5.2.1 Biosensors According to Biorecognition Elements |
|
|
125 | (1) |
|
5.2.1.1 Enzyme Biosensors |
|
|
125 | (1) |
|
|
125 | (1) |
|
5.2.1.3 Nucleic Acid Biosensors |
|
|
126 | (1) |
|
5.2.2 Biosensors According to Transduction Technology |
|
|
126 | (1) |
|
5.2.2.1 Optical Biosensors |
|
|
127 | (1) |
|
5.2.2.2 Piezoelectrical Biosensors |
|
|
127 | (1) |
|
5.2.2.3 Electrochemical Biosensors |
|
|
127 | (1) |
|
5.2.3 Electrochemical DNA Biosensors in Food Analysis |
|
|
127 | (1) |
|
5.2.3.1 Detection of Genetically Modified Organisms (GMOs) |
|
|
128 | (1) |
|
5.2.3.2 Detection of Foodborne Pathogenic Microorganisms |
|
|
129 | (1) |
|
|
130 | (1) |
|
|
130 | (5) |
|
6 Biosensors for the Assessment of Natural Toxins in Food |
|
|
135 | (12) |
|
|
|
|
|
135 | (5) |
|
|
136 | (2) |
|
|
138 | (2) |
|
6.2 Biosensors for Natural Toxins Detection in Food |
|
|
140 | (3) |
|
6.2.1 Electrochemical Biosensors for Natural Toxin Detection and Their Applicability to Food Samples |
|
|
141 | (2) |
|
|
143 | (1) |
|
|
144 | (1) |
|
|
144 | (3) |
|
7 Biosensors for Pesticides and Foodborne Pathogens |
|
|
147 | (46) |
|
|
|
|
|
148 | (1) |
|
|
149 | (1) |
|
7.3 Pesticide Detection Using Biosensors |
|
|
150 | (15) |
|
7.3.1 Enzyme-Based Biosensors for Organophosphorous Pesticides |
|
|
150 | (2) |
|
7.3.1.1 Enzyme Inactivation Problems with AchE |
|
|
152 | (1) |
|
7.3.1.2 Acid Phosphatase Inhibition-Based Detection |
|
|
152 | (1) |
|
7.3.1.3 Ascorbate Oxidase-Based Biosensors |
|
|
153 | (1) |
|
7.3.1.4 Biosensors for Organochlorine Pesticides |
|
|
153 | (1) |
|
|
154 | (1) |
|
7.3.2.1 Advantages of Immunosensor Methods over Conventional Methods |
|
|
154 | (1) |
|
|
154 | (1) |
|
7.3.2.3 Label-Free Formats |
|
|
155 | (1) |
|
7.3.3 Electrochemical Immunosensors |
|
|
156 | (1) |
|
7.3.3.1 Potentiometric Methods |
|
|
156 | (1) |
|
7.3.3.2 Amperometric Methods |
|
|
157 | (1) |
|
7.3.3.3 Capacitance/Conductance/Impedance Methods |
|
|
158 | (1) |
|
7.3.4 Optical Immunosensors |
|
|
158 | (1) |
|
7.3.5 Reflectometric Interference Spectroscopy |
|
|
159 | (1) |
|
|
159 | (1) |
|
7.3.7 Optical Wave-Guide Light Mode Spectroscopy |
|
|
160 | (1) |
|
7.3.8 Total Internal Reflection Fluorescence |
|
|
160 | (1) |
|
7.3.9 Surface Plasmon Resonance |
|
|
161 | (1) |
|
7.3.10 Fluorescence/Luminescence |
|
|
162 | (1) |
|
7.3.11 Piezoelectric Immunosensors |
|
|
163 | (1) |
|
7.3.12 Micronanomechanics Immunosensors |
|
|
164 | (1) |
|
|
165 | (4) |
|
7.4.1 Luminol-Based Chemiluminescence |
|
|
166 | (1) |
|
7.4.2 Chemiluminescent Immunoassays |
|
|
167 | (2) |
|
|
169 | (1) |
|
7.6 Nanoparticle-Based Immunoassays and Immunosensors |
|
|
170 | (6) |
|
7.6.1 Gold Nanoparticle-Based Immunosensors and Immunoassays |
|
|
170 | (4) |
|
7.6.2 Quantum Dot-Based Fluorescence Immunoassays |
|
|
174 | (2) |
|
7.7 Biosensors for Pathogen Detection |
|
|
176 | (5) |
|
|
177 | (1) |
|
7.7.2 Gold Nanoparticle-Based Detection of Pathogens and Their Toxins |
|
|
177 | (2) |
|
7.7.3 Fluoroimmunoassays and Quantum Dot-Based Detection of Pathogens and Their Toxins |
|
|
179 | (2) |
|
|
181 | (2) |
|
|
181 | (2) |
|
|
183 | (1) |
|
|
183 | (1) |
|
|
184 | (1) |
|
|
184 | (9) |
|
8 Impedance Biosensors/Biochips for Detection of Foodborne Pathogens |
|
|
193 | (34) |
|
|
|
194 | (3) |
|
8.1.1 Foodborne Pathogens and Their Detection |
|
|
194 | (1) |
|
8.1.2 Impedance Technique for Foodborne Pathogen Detection |
|
|
195 | (1) |
|
8.1.3 Impedance Properties of Bacterial Cells |
|
|
196 | (1) |
|
8.1.4 Mechanisms for Impedance Detection of Bacteria |
|
|
196 | (1) |
|
8.2 Basics of Impedance Technique |
|
|
197 | (3) |
|
8.2.1 Definition of Impedance |
|
|
197 | (1) |
|
8.2.2 Electrical/Electrochemical Impedance Spectroscopy |
|
|
198 | (1) |
|
|
199 | (1) |
|
8.3 Microfabricated Interdigitated Microelectrodes for Impedance Measurements |
|
|
200 | (2) |
|
8.4 Microchip Impedance Detection of Salmonella Based on Bacterial Metabolism |
|
|
202 | (5) |
|
8.4.1 The Principle of Metabolism-Based Impedance Detection |
|
|
202 | (1) |
|
8.4.2 The Microchip and Methods |
|
|
203 | (1) |
|
8.4.3 Impedance Spectrum of the IME System and Its Equivalent Circuit |
|
|
204 | (1) |
|
8.4.4 Impedance Change Due to the Growth of S. typhimurium |
|
|
205 | (1) |
|
8.4.5 Impedance Detection of S. typhimurium |
|
|
206 | (1) |
|
8.5 Microchip Impedance Detection of Salmonella Based on Ion Release |
|
|
207 | (5) |
|
8.5.1 The Microchip and Methods |
|
|
208 | (1) |
|
8.5.2 Impedance Spectra of Salmonella Cell Suspensions in Deionized (DI) Water and in a Phosphate Buffered Solution (PBS) |
|
|
209 | (1) |
|
8.5.3 Impedance Response to Ion Release from Bacterial Cells in Suspensions |
|
|
210 | (1) |
|
8.5.4 Impedance Detection of Salmonella Cells in Suspensions |
|
|
211 | (1) |
|
8.6 Interdigitated Microelectrode (IME)-Based Impedance Immunosensors for Detection of Escherichia coli O157:H7 |
|
|
212 | (4) |
|
8.6.1 The IME Microchip and Antibody Immobilization |
|
|
213 | (1) |
|
8.6.2 Principle of the Impedance Immunosensor |
|
|
213 | (2) |
|
8.6.3 The Equivalent Circuit and the Measurement of Electron-Tranfer Resistance |
|
|
215 | (1) |
|
8.6.4 Detection of Escherichia coli O157:H7 Cells |
|
|
215 | (1) |
|
8.7 Enhanced Immunocapture of Bacterial Cells on Interdigitated Microelectrodes by Dielectrophoresis |
|
|
216 | (5) |
|
8.7.1 The Microchip Device |
|
|
217 | (1) |
|
8.7.2 Principle of Dielectrophoresis-Enhanced Immunocapture of Bacterial Cells on the Chip |
|
|
218 | (1) |
|
8.7.3 Dielectrophoresis-Enhanced Immunocapture of Salmonella Cells on the Interdigitated Microelectrode |
|
|
219 | (2) |
|
|
221 | (1) |
|
|
221 | (1) |
|
|
221 | (6) |
|
9 Application of Biosensors for the Quality Assurance of Dairy Products |
|
|
227 | (30) |
|
|
|
|
228 | (1) |
|
9.2 General Principle for Biosensors Used in the Dairy Industry |
|
|
229 | (1) |
|
9.3 Applications of Biosensors in the Dairy Industry |
|
|
230 | (18) |
|
9.3.1 Biosensors for Milk Component Analysis |
|
|
230 | (1) |
|
9.3.1.1 Lactose and Other Milk Carbohydrates |
|
|
230 | (8) |
|
|
238 | (1) |
|
|
239 | (1) |
|
9.3.1.4 Milk Enzymes and Hormones |
|
|
240 | (1) |
|
|
240 | (1) |
|
|
241 | (1) |
|
9.3.1.7 Lactate/Lactic Acid |
|
|
241 | (1) |
|
9.3.2 Biosensors for Milk Adulterant and Preservative Analyses |
|
|
242 | (1) |
|
|
242 | (1) |
|
|
243 | (1) |
|
9.3.3 Biosensors for Milk Contaminant Analysis |
|
|
243 | (1) |
|
9.3.3.1 Antibiotics and Veterinary Drug Residues |
|
|
243 | (2) |
|
9.3.3.2 Pesticide Residues and Dioxins |
|
|
245 | (1) |
|
9.3.4 Biosensors for Detection of Microbes and Their Metabolites in Dairy Products |
|
|
246 | (1) |
|
9.3.4.1 Pathogenic Microorganisms |
|
|
247 | (1) |
|
|
248 | (1) |
|
|
248 | (1) |
|
|
249 | (1) |
|
|
249 | (8) |
|
10 Electrochemical Biosensors as a Tool for the Determination of Phenolic Compounds and Antioxidant Capacity in Foods and Beverages |
|
|
257 | (16) |
|
|
|
|
|
|
257 | (1) |
|
10.2 Biosensors for Determination of the Total Phenol Content |
|
|
258 | (5) |
|
10.2.1 Polyphenol Oxidase-Based Biosensors |
|
|
259 | (1) |
|
10.2.1.1 Tyrosinase-Based Biosensors |
|
|
259 | (2) |
|
10.2.1.2 Laccase-Based Biosensors |
|
|
261 | (1) |
|
10.2.2 Peroxidase-Based Biosensors |
|
|
262 | (1) |
|
10.3 Biosensors for Determination of the Reactive Oxygen Species (ROS) Scavenging Capacity |
|
|
263 | (5) |
|
10.3.1 Cyt c-Based Biosensors |
|
|
264 | (2) |
|
10.3.2 Superoxide Dismutase-Based Biosensors |
|
|
266 | (1) |
|
10.3.3 DNA-Based Biosensors |
|
|
267 | (1) |
|
|
268 | (1) |
|
|
269 | (1) |
|
|
269 | (4) |
|
11 Neural Networks Their Role in the Field of Sensors |
|
|
273 | (14) |
|
|
|
273 | (1) |
|
|
274 | (5) |
|
|
274 | (4) |
|
11.2.2 Principal Component Analysis Description |
|
|
278 | (1) |
|
|
278 | (1) |
|
11.3 Principal Results and Discussions |
|
|
279 | (4) |
|
11.3.1 Determination of Two Ionic Liquids, Heptane, and Toluene Concentrations |
|
|
279 | (2) |
|
11.3.2 Determination of Carotenoid Concentrations in Foods |
|
|
281 | (1) |
|
11.3.3 Determination of Polyphenolic Compounds Concentrations in Olive Oil Mill Wastewater |
|
|
281 | (1) |
|
11.3.4 Determination of Glucose, Uric Acid, and Ascorbic Acid in Biological Mixtures |
|
|
282 | (1) |
|
11.3.5 Identification of Edible and Vegetable Oils and Detection of Extra Virgin Olive Oil (EVOO) Adulteration |
|
|
282 | (1) |
|
|
283 | (1) |
|
|
284 | (3) |
|
12 Trends in Biosensing and Biosensors |
|
|
287 | (38) |
|
|
|
|
287 | (1) |
|
12.2 Electrochemical Sensing |
|
|
288 | (9) |
|
12.2.1 Conducting Polymers |
|
|
289 | (4) |
|
12.2.2 Electrochemical Microarrays |
|
|
293 | (1) |
|
12.2.3 Incorporation of Nanosized Objects into Electrochemical Systems |
|
|
294 | (2) |
|
12.2.4 Practical Applications of Electrochemical Sensors |
|
|
296 | (1) |
|
|
297 | (3) |
|
12.4 Quartz Crystal Microbalance and Surface Acoustic Wave Sensors |
|
|
300 | (2) |
|
12.5 Micro-and Nanobiosensors |
|
|
302 | (5) |
|
12.5.1 Miniaturized Transducers |
|
|
303 | (1) |
|
|
303 | (2) |
|
|
305 | (2) |
|
12.6 Gold-Thiol Monolayers |
|
|
307 | (3) |
|
|
310 | (4) |
|
|
314 | (1) |
|
12.9 Applications of Biosensors and Conclusions |
|
|
315 | (1) |
|
|
315 | (10) |
Index |
|
325 | |