| List of Contributors |
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xii | |
| Preface to the Second Edition |
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xvi | |
| Foreword to the First Edition |
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xvii | |
| Acknowledgments |
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xix | |
| Chapter 1 Introduction |
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1 | (4) |
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| Chapter 2 Diagnostic Approach in Bone and Joint Infections |
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5 | (16) |
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5 | (2) |
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Common Microorganisms Causing Bone and Joint Infection |
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7 | (1) |
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Diagnostic Approach in Spinal Infection |
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8 | (2) |
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Diagnostic Approach in Bone Fixation Device-Associated Infection |
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10 | (2) |
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Diagnostic Approach in Native Arthritis and Infections after Anterior Cruciate Ligament Repair (ACL-R) |
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12 | (3) |
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Diagnostic Approach in Periprosthetic Joint Infections (PJI) |
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15 | (2) |
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17 | (1) |
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17 | (4) |
| Chapter 3 Unusual Microorganisms in Periprosthetic Joint Infection |
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21 | (30) |
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21 | (1) |
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Gram-Positive Microorganisms |
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21 | (5) |
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Gram-Negative Microorganisms |
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26 | (3) |
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29 | (5) |
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34 | (1) |
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35 | (3) |
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38 | (2) |
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40 | (1) |
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40 | (11) |
| Chapter 4 Identification of Pathogens in Bone and Joint Infections by Non-Culture Techniques |
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51 | (14) |
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51 | (1) |
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51 | (2) |
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53 | (1) |
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54 | (1) |
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Next-Generation Sequencing Approach |
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55 | (3) |
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Mass Spectrometry-Based Methods |
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58 | (3) |
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61 | (1) |
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61 | (4) |
| Chapter 5 Bacteriophages for Treatment of Biofilm Infections |
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65 | (16) |
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History of Bacteriophage Use in Human Infections |
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65 | (1) |
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Principles of Bacteriophage Therapy |
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66 | (3) |
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Activity of Bacteriophages against Bacterial Biofilms and Persisters |
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69 | (2) |
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Bacteriophage Susceptibility Testing: the Phagogram |
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71 | (1) |
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Experimental and Clinical Evidence with Bacteriophage Treatment |
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72 | (2) |
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Local Delivery and Systemic Bacteriophage Application |
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74 | (2) |
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Outlook and Future Perspectives |
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76 | (1) |
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77 | (1) |
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78 | (3) |
| Chapter 6 Pharmacokinetics and Pharmacodynamics of Antibiotics in Bone |
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81 | (18) |
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Cornelia B. Landersdorfer |
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81 | (1) |
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Bone Sample Preparation and Analysis |
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82 | (1) |
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Pharmacokinetic Sampling and Data Analysis |
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83 | (1) |
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Penetration of Antibiotics into Bone |
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84 | (9) |
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Pharmacodynamics and Monte Carlo Simulations |
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93 | (2) |
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95 | (1) |
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96 | (1) |
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96 | (3) |
| Chapter 7 Preclinical Models of Infection in Bone and Joint Surgery |
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99 | (18) |
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99 | (1) |
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Influence of Species in Preclinical Models of Bone and Joint Infection |
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100 | (3) |
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Overview of Animal Models |
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103 | (1) |
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Direct Inoculation with Minimal Trauma |
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103 | (5) |
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Animal Models of Bone and Joint Infection Incorporating Trauma |
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108 | (1) |
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108 | (1) |
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109 | (1) |
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110 | (1) |
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110 | (1) |
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110 | (7) |
| Chapter 8 Native Joint Arthritis in Children |
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117 | (22) |
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117 | (1) |
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117 | (1) |
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118 | (4) |
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122 | (1) |
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123 | (2) |
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125 | (2) |
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127 | (1) |
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128 | (1) |
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128 | (5) |
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133 | (1) |
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134 | (1) |
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134 | (5) |
| Chapter 9 Native Joint Arthritis in Adults |
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139 | (12) |
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139 | (1) |
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139 | (1) |
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Pathogenesis, Epidemiology, and Microbiology |
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140 | (1) |
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141 | (3) |
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144 | (3) |
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147 | (1) |
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148 | (1) |
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148 | (1) |
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148 | (3) |
| Chapter 10 Septic Arthritis of Axial Joints |
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151 | (20) |
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Septic Arthritis of the Sternoclavicular Joint |
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151 | (6) |
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157 | (1) |
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Septic Arthritis of the Symphysis Pubis |
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157 | (4) |
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161 | (1) |
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Septic Arthritis of the Sacroiliac Joint |
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161 | (4) |
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165 | (1) |
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165 | (6) |
| Chapter 11 Periprosthetic Joint Infection: General Aspects |
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171 | (16) |
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171 | (1) |
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172 | (1) |
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172 | (1) |
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172 | (4) |
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176 | (2) |
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178 | (1) |
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179 | (1) |
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Errors in the Management of PJI |
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180 | (1) |
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180 | (1) |
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181 | (6) |
| Chapter 12 Periprosthetic Joint Infection after Total Hip and Knee Arthroplasty |
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187 | (26) |
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187 | (1) |
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188 | (1) |
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188 | (1) |
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189 | (1) |
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190 | (1) |
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191 | (1) |
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192 | (10) |
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202 | (4) |
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206 | (7) |
| Chapter 13 Periprosthetic Joint Infection after Shoulder Arthroplasty |
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213 | (18) |
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213 | (1) |
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213 | (2) |
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215 | (1) |
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216 | (1) |
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217 | (1) |
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218 | (2) |
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220 | (1) |
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220 | (4) |
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224 | (2) |
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226 | (5) |
| Chapter 14 Periprosthetic Joint Infection after Elbow Arthroplasty |
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231 | (20) |
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231 | (1) |
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232 | (1) |
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232 | (2) |
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234 | (3) |
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237 | (5) |
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242 | (3) |
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245 | (6) |
| Chapter 15 Periprosthetic Joint Infection after Ankle Arthroplasty |
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251 | (14) |
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251 | (1) |
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252 | (2) |
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254 | (1) |
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254 | (1) |
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255 | (1) |
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256 | (1) |
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257 | (3) |
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260 | (2) |
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262 | (3) |
| Chapter 16 Osteomyelitis: Classification |
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265 | (8) |
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Classification According to Pathogenesis |
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265 | (2) |
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Classification According to the Duration of Infection |
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267 | (1) |
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Classification According to the Localization |
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268 | (1) |
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Classification According to the Presence of an Implant |
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269 | (1) |
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Classification According to Anatomy and Comorbidity |
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269 | (1) |
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270 | (3) |
| Chapter 17 Osteomyelitis in Children |
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273 | (16) |
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273 | (1) |
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273 | (1) |
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274 | (1) |
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Clinical Presentation, Diagnosis, and Microbiology |
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275 | (7) |
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282 | (2) |
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284 | (1) |
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285 | (1) |
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286 | (3) |
| Chapter 18 Acute Osteomyelitis in Adults |
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289 | (20) |
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289 | (1) |
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289 | (1) |
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290 | (1) |
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291 | (2) |
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293 | (2) |
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295 | (1) |
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296 | (2) |
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298 | (2) |
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Clinical and Imaging Differential Diagnosis |
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300 | (1) |
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301 | (3) |
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304 | (1) |
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304 | (5) |
| Chapter 19 Subacute Osteomyelitis: Tuberculous and Brucellar Vertebral Osteomyelitis |
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309 | (16) |
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309 | (1) |
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309 | (1) |
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310 | (2) |
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312 | (3) |
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315 | (3) |
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Antimicrobial and Surgical Therapy |
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318 | (3) |
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321 | (1) |
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321 | (4) |
| Chapter 20 Chronic Osteomyelitis in Adults |
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325 | (12) |
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325 | (1) |
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326 | (1) |
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326 | (2) |
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328 | (5) |
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333 | (1) |
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333 | (1) |
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333 | (4) |
| Chapter 21 Diabetic Foot Osteomyelitis |
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337 | (16) |
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337 | (1) |
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337 | (2) |
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339 | (2) |
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341 | (1) |
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342 | (1) |
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342 | (1) |
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343 | (1) |
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344 | (3) |
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347 | (1) |
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348 | (5) |
| Chapter 22 Osteomyelitis of the Jaws |
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353 | (14) |
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353 | (1) |
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353 | (2) |
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355 | (1) |
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356 | (1) |
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356 | (3) |
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359 | (1) |
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360 | (1) |
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361 | (2) |
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363 | (1) |
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364 | (3) |
| Chapter 23 Fracture-Related Infection of the Long Bones |
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367 | (20) |
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367 | (1) |
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Classification and Risk Factors |
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368 | (2) |
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370 | (1) |
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371 | (1) |
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372 | (1) |
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373 | (1) |
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373 | (7) |
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380 | (3) |
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383 | (4) |
| Chapter 24 Implant-Associated Vertebral Osteomyelitis |
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387 | (22) |
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387 | (1) |
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Classification and Risk Factors |
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388 | (1) |
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389 | (4) |
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393 | (1) |
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393 | (2) |
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395 | (7) |
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402 | (2) |
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404 | (5) |
| Chapter 25 Postoperative Sternal Osteomyelitis |
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409 | (20) |
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409 | (1) |
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410 | (4) |
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414 | (1) |
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414 | (1) |
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415 | (2) |
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417 | (1) |
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417 | (5) |
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422 | (3) |
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425 | (4) |
| Index |
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429 | |