| Contributors |
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ix | |
| Preface |
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xi | |
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1 | (12) |
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1.1 Two-Dimensional Chromatography-Mass Spectrometry: A 50-Year-Old Combination |
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2 | (1) |
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1.2 Shortcomings of One-Dimensional Chromatography |
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3 | (3) |
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1.3 Benefits of Two-Dimensional Chromatography |
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6 | (1) |
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7 | (4) |
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11 | (2) |
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2 Multidimensional Gas Chromatography: Theoretical Considerations |
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13 | (52) |
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15 | (2) |
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17 | (14) |
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2.3 Comprehensive GC × GC |
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31 | (34) |
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3 Multidimensional Liquid Chromatography: Theoretical Considerations |
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65 | (28) |
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3.1 Two-Dimensional LC Techniques |
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66 | (3) |
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3.2 Peak Capacity in HPLC: One- and Multidimensional Separations |
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69 | (4) |
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3.3 Orthogonality in Two-Dimensional LC-LC Systems |
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73 | (2) |
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3.4 Sample Dimensionality and Structural Correlations |
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75 | (4) |
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3.5 Separation Selectivity and Selection of Phase Systems in Two-Dimensional LC-LC |
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79 | (2) |
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3.6 Programmed Elution in Two-Dimensional HPLC |
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81 | (6) |
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3.7 Fraction Transfer Modulation in Comprehensive LC × LC: Additional Band Broadening |
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87 | (2) |
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89 | (4) |
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4 History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Gas Chromatography |
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93 | (52) |
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4.1 Fundamentals of GC × GC |
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94 | (2) |
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96 | (1) |
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4.3 GC × GC Data Interpretation |
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97 | (3) |
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4.4 GC × GC Instrumentation |
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100 | (1) |
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101 | (14) |
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4.6 Comprehensive Two-Dimensional GC Method Optimization |
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115 | (25) |
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140 | (5) |
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5 Flow-Modulated Comprehensive Two-Dimensional Gas Chromatography |
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145 | (26) |
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5.1 Timing Requirements of GC × GC Modulators |
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145 | (5) |
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5.2 Criteria for Evaluating Modulators |
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150 | (1) |
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151 | (1) |
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5.4 Single-Stage Flow Modulation |
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152 | (5) |
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5.5 Two-Stage Flow Modulation |
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157 | (10) |
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5.6 Summary of Flow Modulators |
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167 | (2) |
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5.7 Brief Comparison to Thermal Modulation |
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169 | (1) |
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169 | (2) |
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6 Comprehensive Two-Dimensional Gas Chromatography Combined with Mass Spectrometry |
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171 | (72) |
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6.1 Instrument Requirements for GC × GC-MS |
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173 | (7) |
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6.2 Data Processing of GC × GC-TOF MS Results |
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180 | (1) |
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6.3 Method Translation in GC × GC-MS |
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181 | (1) |
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181 | (3) |
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6.5 Conventional and Alternative Modulation Techniques for GC × GC-MS |
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184 | (3) |
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6.6 GC × GC-MS Applications |
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187 | (45) |
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232 | (11) |
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7 Detector Technologies and Applications in Comprehensive Two-Dimensional Gas Chromatography |
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243 | (38) |
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244 | (5) |
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7.2 Comments on GC × GC with Mass Spectrometry |
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249 | (1) |
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7.3 Flame Ionization Detection in GC × GC |
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250 | (4) |
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7.4 Electron Capture Detection in GC × GC |
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254 | (6) |
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7.5 Sulfur Chemiluminescence Detection in GC × GC |
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260 | (3) |
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7.6 Nitrogen Chemiluminescence Detection in GC × GC |
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263 | (2) |
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7.7 Atomic Emission Detection in GC × GC |
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265 | (2) |
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7.8 Thermionic Detection in GC × GC |
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267 | (2) |
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7.9 Flame Photometric Detection in GC × GC |
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269 | (3) |
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7.10 Case Study of GC × GC with Selective Detection |
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272 | (2) |
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7.11 Dual Detection with GC × GC |
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274 | (1) |
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275 | (6) |
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8 History, Evolution, and Optimization Aspects of Comprehensive Two-Dimensional Liquid Chromatography |
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281 | (50) |
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8.1 Method Development and Instrumentation |
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282 | (27) |
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8.2 Technical Problems in Comprehensive Liquid Chromatography |
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309 | (5) |
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314 | (1) |
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315 | (1) |
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316 | (1) |
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8.6 Milestones in Comprehensive Liquid Chromatography |
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317 | (3) |
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320 | (1) |
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8.8 Beyond Two-Dimensional Chromatography |
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320 | (1) |
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8.9 Comparison of LC × LC and Off-Line 2D LC |
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321 | (4) |
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325 | (6) |
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9 Comprehensive Two-Dimensional Liquid Chromatography Combined with Mass Spectrometry |
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331 | (60) |
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332 | (2) |
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9.2 LC × LC-MS Instrumentation and Method Development |
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334 | (2) |
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9.3 LC × LC-MS Applications |
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336 | (55) |
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10 Comprehensive Two-Dimensional Liquid Chromatography Applications |
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391 | (38) |
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10.1 Comprehensive 2D LC Separation of Synthetic and Natural Polymers |
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392 | (7) |
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10.2 Comprehensive 2D LC Separation of Natural Products and Antioxidants |
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399 | (13) |
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10.3 Comprehensive 2D LC Separation of Pharmaceutical and Environmental Compounds |
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412 | (5) |
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10.4 Comprehensive 2D LC Separation of Proteins and Peptides |
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417 | (12) |
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11 Other Comprehensive Chromatography Methods |
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429 | (20) |
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11.1 Online Two-Dimensional Liquid Chromatography-Gas Chromatography |
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430 | (10) |
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11.2 Online Two-Dimensional Supercritical Fluid Chromatography-Gas Chromatography |
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440 | (1) |
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11.3 Online Two-Dimensional Supercritical Fluid Chromatography-Supercritical Fluid Chromatography |
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440 | (2) |
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11.4 Online Two-Dimensional Supercritical Fluid Chromatography-Liquid Chromatography |
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442 | (7) |
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12 Comprehensive Chromatography Data Interpretation Technologies |
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449 | (28) |
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12.1 Higher-Order Data Structure |
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450 | (3) |
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12.2 Modifications of First-Order Data-Handling Approaches |
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453 | (3) |
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456 | (5) |
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12.4 Mass Spectral Detection |
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461 | (2) |
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463 | (9) |
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12.6 Summary of Data Interpretation Technologies |
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472 | (5) |
| Index |
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477 | |
