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Computer Modelling for Nutritionists 2019 ed. [Kõva köide]

  • Formaat: Hardback, 103 pages, kõrgus x laius: 235x155 mm, kaal: 454 g, XIII, 103 p., 1 Hardback
  • Ilmumisaeg: 21-Oct-2019
  • Kirjastus: Springer International Publishing AG
  • ISBN-10: 3319399926
  • ISBN-13: 9783319399928
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Computer Modelling for Nutritionists 2019 ed.Suurem pilt
  • Formaat: Hardback, 103 pages, kõrgus x laius: 235x155 mm, kaal: 454 g, XIII, 103 p., 1 Hardback
  • Ilmumisaeg: 21-Oct-2019
  • Kirjastus: Springer International Publishing AG
  • ISBN-10: 3319399926
  • ISBN-13: 9783319399928
Teised raamatud teemal:
Püsilink: https://www.kriso.ee/db/9783319399928.html
Märksõnad:
This book draws on Mark Mc Auley’s wealth of experience to provide an intuitive step-by-step guide to the modelling process. It also provides case studies detailing the creation of biological process models. Mark Mc Auley has over 15 years’ experience of applying computing to challenges in bioscience. Currently he is employed as a Senior Lecturer in Chemical Engineering at the University of Chester. He has published widely on the use of computer modelling in nutrition and uses computer modelling to both enhance and enrich the learning experience of the students that he teaches. He has taught computer modelling to individuals at a wide variety of levels and from different backgrounds, from undergraduate nutrition students to PhD and medical students.

Kathleen Mooney is a Senior Lecturer in Nutrition at Edge Hill University. She has almost ten years’ experience teaching nutrition to undergraduate and postgraduate students, and uses this to ensure that
the book focuses on the learner. The most difficult part of any modelling project is getting started and selecting nutrient-based biochemical systems that are familiar to all nutritionists facilitates this process. A philosophy of simplification is adopted, which involves no prior programming or modelling experience.
1 Introduction
1(18)
1.1 Introduction: The Systems Biology Paradigm Shift
1(1)
1.2 What Is Computational Modelling?
1(2)
1.3 Why Nutrition Needs Modelling
3(1)
1.4 Computer Models and Nutrition Research
3(9)
1.4.1 Folate Metabolism
4(1)
1.4.2 Models of Folate Metabolism
4(3)
1.4.3 Cholesterol Metabolism
7(1)
1.4.4 Models of Cholesterol Metabolism
8(4)
1.5 Can Modelling Unravel the Relationship Between Diet and Healthspan?
12(1)
1.6 Exercises
13(1)
References
13(6)
2 Kinetics
19(12)
2.1 What Is Kinetics?
19(1)
2.2 Deterministic Kinetics and the Law of Mass Action
20(1)
2.3 Zero Order Reactions
20(2)
2.4 First Order Reactions
22(4)
2.5 Second Order Rate Laws
26(3)
2.6 Exercises
29(1)
References
29(2)
3 Enzyme Kinetics
31(10)
3.1 Introduction
31(6)
3.1.1 Michaelis-Menten Kinetics
33(3)
3.1.2 Michaelis Menten (Reversible)
36(1)
3.2 Enzyme Inhibition
37(1)
3.3 The Hill Equation
38(1)
3.4 Exercises
39(1)
References
40(1)
4 Model Building: Part One
41(14)
4.1 The Steps in Building a Kinetic Model
41(1)
4.2 Step One: Identifying a System to Model and Defining a Hypothesis
42(1)
4.3 Step Two: Listing the Variables and How They Interact
43(1)
4.4 Step Three: Creating a Network Diagram
44(1)
4.5 Step Four: Identifying and Using a Software Tool
44(1)
4.6 Step Five: Adding Biochemical Reactions
45(8)
4.6.1 Adding a Rate Law Which Does Not Exist in COPASI/CellDesigner
49(4)
4.7 Exercises
53(1)
References
54(1)
5 Model Building: Part Two
55(8)
5.1 Introduction
55(1)
5.2 Step Six: Model Parameterization
55(1)
5.3 Step Seven: Model Simulation
56(2)
5.4 Step Eight: Validation and Hypothesis Exploration
58(2)
5.5 Step Ten: Model Archiving
60(1)
5.6 Exercises
61(1)
References
62(1)
6 Model Analysis in Greater Depth
63(16)
6.1 Steady State Analysis
63(2)
6.2 Phase Space Analysis
65(1)
6.3 Parameter Perturbations and Bifurcations
66(2)
6.4 The Brusselator and Limit Cycles
68(2)
6.5 Identifying the Stability of Larger Models
70(2)
6.5.1 Identifying Model Stability Using COPASI
72(1)
6.6 Performing a Local Parameter Scan
72(2)
6.7 Metabolic Control Analysis
74(2)
6.8 Performing a Sensitivity Analysis
76(2)
6.9 Exercises
78(1)
References
78(1)
7 Investigating Cholesterol Metabolism and Its Intersection with Ageing
79(14)
7.1 Cholesterol Metabolism: Some Mechanistic Detail
79(2)
7.2 Cholesterol Absorption and Ageing
81(5)
7.3 Hepatic LDLr and Ageing
86(1)
7.4 Cholesterol Biosynthesis
87(1)
7.5 Exercises
88(2)
References
90(3)
8 Modelling Folate Metabolism and DNA Methylation
93(8)
8.1 Introduction
93(1)
8.2 Explore Folate Metabolism and Health
93(3)
8.3 Computationally Modelling DNA Methylation
96(1)
8.4 Stochastic Modelling DNA Methylation
97(1)
8.5 Rationale for Modelling DNA Methylation Using a Stochastic Framework
98(1)
8.6 Exercises
99(1)
References
100(1)
Index 101
Mark Mc Auley has over 15 years experience of applying computing to challenges in bioscience. Presently he is employed as a senior lecturer in chemical engineering at the University of Chester. He has published widely on the use of computer modelling in nutrition and uses computer modelling to both enhance and enrich the learning experience of the students that he teaches. He has taught computer modelling to individuals from a wide variety of levels and backgrounds from undergraduate nutrition students to PhD and medical students.  This book draws on his wealth of experience to provide an intuitive step by step guide to the modelling process.