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Mims' Medical Microbiology and Immunology 6th edition [Pehme köide]

(Professor and Chair, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA), , , (Professor of Immunology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and)
  • Formaat: Paperback / softback, 568 pages, kõrgus x laius: 276x216 mm, kaal: 1540 g, 946 illustrations (946 in full color); Illustrations
  • Ilmumisaeg: 27-Feb-2018
  • Kirjastus: Elsevier Health Sciences
  • ISBN-10: 0702071544
  • ISBN-13: 9780702071546
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  • Formaat: Paperback / softback, 568 pages, kõrgus x laius: 276x216 mm, kaal: 1540 g, 946 illustrations (946 in full color); Illustrations
  • Ilmumisaeg: 27-Feb-2018
  • Kirjastus: Elsevier Health Sciences
  • ISBN-10: 0702071544
  • ISBN-13: 9780702071546
Teised raamatud teemal:
Learn all the microbiology and basic immunology concepts you need to know for your courses and exams. Now fully revised and updated, Mims clinically relevant, systems-based approach and abundant colour illustrations make this complex subject easy to understand and remember. Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the bug parade into a clinical context. Effectively review for problem-based courses with the help of chapter introductions and Lessons in Microbiology text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools. Approach microbiology by body system or by pathogen through the accompanying electronic Pathogen Parade - a quickly searchable, cross-referenced glossary of viruses, bacteria and fungi A new electronic Vaccine Parade offers quick-reference coverage of the most commonly used vaccines in current clinical practice Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventative medicine.? Grasp and retain vital concepts easily, with a user-friendly colour coded format, succinct text, key concept boxes, and dynamic illustrations. New and enhanced information reflects the growing importance of the human microbiota and latest molecular approaches Access the complete contents on the go via the accompanying interactive eBook, with a range of bonus materials to enhance learning and retention - includes self-assessment materials and clinical cases to check your understanding and aid exam preparation.

Arvustused

"The book is useful for the intended audience without being too exhaustive.Each topic is treated with an intermediate level of depth without being exhaustive and is comprehensible for readers new to the subject."

-Matthias J. Schnell, PhD (Thomas Jefferson University) for Doody's Review Services

Foreword ix
Cedric Mims
Preface to the sixth edition x
Acknowledgements xi
A contemporary approach to microbiology xii
Introduction xii
The context for contemporary medical microbiology xii
Microbiology past, present and future xiii
The approach adopted in this book xv
SECTION 1 THE ADVERSARIES -- PATHOGENS
1 Pathogens as parasites
2(4)
The varieties of pathogens
2(1)
Living inside or outside cells
3(1)
Systems of classification
4(2)
2 The bacteria
6(21)
Structure
6(2)
Nutrition
8(1)
Growth and division
9(2)
Gene expression
11(3)
Survival under adverse conditions
14(1)
Mobile genetic elements
15(5)
Mutation and gene transfer
20(3)
The genomics of medically important bacteria
23(4)
3 The viruses
27(8)
Major groups of viruses
27(1)
Infection of host cells
28(1)
Replication
29(2)
Outcome of viral infection
31(4)
4 The fungi
35(3)
Major groups of disease-causing fungi
35(3)
5 The protozoa
38(3)
6 The helminths
41(4)
Life cycles
42(1)
Helminths and disease
42(3)
7 The arthropods
45(2)
8 Prions
47(5)
`Rogue protein' pathogenesis
47(1)
Development, transmission and diagnosis of prion diseases
48(2)
Prevention and treatment of prion diseases
50(2)
9 The host--parasite relationship
52(12)
The microbiota and microbiome
52(3)
Symbiotic associations
55(1)
The characteristics of parasitism
56(1)
The evolution of parasitism
57(7)
SECTION 2 THE ADVERSARIES -- HOST DEFENCES
10 The innate defences of the body
64(16)
Defences against entry into the body
64(1)
Defences once the microorganism penetrates the body
65(15)
11 Adaptive immune responses bring specificity
80(10)
Lymphoid tissues: primary and secondary
80(1)
The thymus
80(3)
Secondary lymphoid organs
83(1)
Subsets of T cells
83(2)
Antibody structure and function
85(2)
Antibodies classes and subclasses
87(1)
Subsets of B cells
88(1)
Recirculation of T and B cells
88(2)
12 Cooperation leads to effective immune responses
90(14)
Cooperation means greater efficiency
90(1)
Opsonization by antibody
90(1)
Beneficial inflammatory reactions can also be enhanced by antibodies
90(1)
Activation of T cells
91(3)
Clonal expansion
94(1)
Antibody production
95(1)
Cytokines play an important part in these cell--cell interactions
96(1)
Immunological memory
97(2)
Armies must be kept under control
99(5)
SECTION 3 THE CONFLICTS
13 Background to the infectious diseases
104(7)
Host--parasite relationships
104(4)
Causes of infectious diseases
108(2)
The biological response gradient
110(1)
14 Entry, exit and transmission
111(18)
Sites of entry
111(7)
Exit and transmission
118(1)
Types of transmission between humans
119(5)
Transmission from animals
124(5)
15 Immune defences in action
129(15)
Complement
129(1)
Acute phase proteins and pattern recognition receptors
129(2)
Fever
131(1)
Natural killer cells
131(1)
Phagocytosis
132(2)
Cytokines
134(2)
Antibody-mediated immunity
136(3)
Cell-mediated immunity
139(4)
Recovery from infection
143(1)
16 Spread and replication
144(8)
Features of surface and systemic infections
145(1)
Mechanisms of spread through the body
146(2)
Genetic determinants of spread and replication
148(2)
Other factors affecting spread and replication
150(2)
17 Parasite survival strategies and persistent infections
152(16)
Parasite survival strategies
154(1)
Concealment of antigens
154(5)
Antigenic variation
159(1)
Immunosuppression
160(3)
Persistent infections
163(5)
18 Pathological consequences of infection
168(19)
Pathology caused directly by microorganisms
168(4)
Diarrhoea
172(1)
Pathological activation of natural immune mechanisms
173(3)
Pathological consequences of the immune response
176(4)
Skin rashes
180(2)
Viruses and cancer
182(5)
SECTION 4 CLINICAL MANIFESTATION AND DIAGNOSIS OF INFECTIONS BY BODY SYSTEM
The clinical manifestations of infection
187(2)
19 Upper respiratory tract infections
189(15)
Rhinitis
189(3)
Pharyngitis and tonsillitis
192(7)
Parotitis
199(1)
Otitis and sinusitis
200(1)
Acute epiglottitis
201(1)
Oral cavity infections
201(3)
20 Lower respiratory tract infections
204(30)
Laryngitis and tracheitis
204(1)
Diphtheria
204(2)
Whooping cough
206(1)
Acute bronchitis
207(1)
Acute exacerbations of chronic bronchitis
207(1)
Bronchiolitis
208(1)
Respiratory syncytial virus (RSV) infection
208(1)
Hantavirus pulmonary syndrome (HPS)
209(1)
Pneumonia
209(4)
Bacterial pneumonia
213(3)
Viral pneumonia
216(1)
Parainfluenza virus infection
216(1)
Adenovirus infection
217(1)
Human metapneumovirus infection
217(1)
Human bocavirus infection
217(1)
Influenza virus infection
217(5)
Severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus infections
222(2)
Measles virus infection
224(1)
Cytomegalovirus infection
225(1)
Tuberculosis
225(4)
Cystic fibrosis
229(1)
Lung abscess
229(1)
Fungal infections
230(1)
Protozoal infections
231(3)
21 Urinary tract infections
234(7)
Acquisition and aetiology
234(1)
Pathogenesis
235(1)
Clinical features and complications
236(1)
Laboratory diagnosis
237(2)
Treatment
239(1)
Prevention
240(1)
22 Sexually transmitted infections
241(24)
STIs and sexual behaviour
241(1)
Syphilis
241(4)
Gonorrhoea
245(2)
Chlamydial infection
247(2)
Other causes of inguinal lymphadenopathy
249(1)
Mycoplasmas and non-gonococcal urethritis
250(1)
Other causes of vaginitis and urethritis
250(2)
Genital herpes
252(1)
Human papillomavirus infection
253(1)
Human immunodeficiency virus
253(11)
Opportunist STIs
264(1)
Arthropod infestations
264(1)
23 Gastrointestinal tract infections
265(40)
Diarrhoeal diseases caused by bacterial or viral infection
266(11)
Food poisoning -- bacterial toxin-associated diarrhoea
277(4)
Viral causes of diarrhoea
281(2)
Helicobacter pylori and gastric ulcer disease
283(1)
Parasites and the gastrointestinal tract
284(7)
Systemic infection initiated in the gastrointestinal tract
291(2)
Viral hepatitis
293(12)
24 Obstetric and perinatal infections
305(9)
Infections occurring in pregnancy
305(1)
Congenital infections
306(5)
Infections occurring around the time of birth
311(3)
25 Central nervous system infections
314(17)
Invasion of the central nervous system
314(1)
The body's response to invasion
315(1)
Meningitis
316(5)
Encephalitis
321(6)
Neurological diseases of possible viral aetiology
327(1)
Spongiform encephalopathies caused by scrapie-type agents
327(1)
CNS disease caused by parasites
327(2)
Brain abscesses
329(1)
Tetanus and botulism
329(2)
26 Infections of the eye
331(5)
Conjunctivitis
331(3)
Infection of the deeper layers of the eye
334(2)
27 Infections of the skin, soft tissue, muscle and associated systems
336(33)
Bacterial infections of skin, soft tissue and muscle
338(5)
Mycobacterial diseases of the skin
343(3)
Fungal infections of the skin
346(5)
Parasitic infections of the skin
351(1)
Mucocutaneous manifestations of viral infections
352(7)
Smallpox virus infection
359(1)
Measles virus infection
360(2)
Rubella virus infection
362(1)
Other maculopapular rashes associated with travel-related infections
362(1)
Other infections producing skin lesions
363(1)
Kawasaki syndrome
363(1)
Viral infections of muscle
363(1)
Parasitic infections of muscle
364(1)
Joint and bone infections
365(1)
Infections of the haemopoietic system
366(3)
28 Vector-borne infections
369(17)
Arbovirus infections
369(3)
Infections caused by rickettsiae
372(3)
Borrelia infections
375(2)
Protozoal infections
377(6)
Helminth infections
383(3)
29 Multisystem zoonoses
386(14)
Arenavirus infections
386(2)
Haemorrhagic fever with renal syndrome (HFRS)
388(1)
Ebola and Marburg haemorrhagic fevers
388(2)
Crimean--Congo haemorrhagic fever, a tick-borne virus
390(1)
Q fever
391(1)
Anthrax
391(1)
Plague
392(1)
Yersinia enterocolitica infection
393(1)
Tularaemia
393(1)
Pasteurella multocida infection
394(1)
Leptospirosis
394(1)
Rat-bite fever
395(1)
Brucellosis
396(1)
Helminth infections
397(3)
30 Fever of unknown origin
400(8)
Definitions of fever of unknown origin
400(1)
Causes of FUO
400(1)
Investigation of classic FUO
401(3)
Treatment of FUO
404(1)
FUO in specific patient groups
404(1)
Infective endocarditis
404(4)
31 Infections in the compromised host
408(14)
The compromised host
408(2)
Infections of the host with deficient innate immunity due to physical factors
410(3)
Infections associated with secondary adaptive immunodeficiency
413(1)
Other important opportunist pathogens
414(8)
SECTION 5 DIAGNOSIS AND CONTROL
32 Diagnosis of infection and assessment of host defence mechanisms
422(17)
Aims of the clinical microbiology laboratory
422(1)
Specimen processing
422(1)
Cultivation (culture) of microorganisms
423(1)
Identification of microorganisms grown in culture
424(3)
Non-cultural techniques for the laboratory diagnosis of infection
427(8)
Antibody detection methods for the diagnosis of infection
435(1)
Assessment of host defence systems
435(2)
Putting it all together: detection, diagnosis and epidemiology
437(2)
33 Epidemiology and control of infectious diseases
439(8)
Outcome measurements
439(1)
Types of epidemiological studies
439(5)
Transmission of infectious disease
444(2)
Vaccine efficacy
446(1)
34 Attacking the enemy: antimicrobial agents and chemotherapy
447(43)
Selective toxicity
447(1)
Discovery and design of antimicrobial agents
447(2)
Classification of antibacterial agents
449(1)
Resistance to antibacterial agents
449(2)
Classes of antibacterial agents
451(1)
Inhibitors of cell wall synthesis
451(6)
Inhibitors of protein synthesis
457(8)
Inhibitors of nucleic acid synthesis
465(1)
Antimetabolites affecting nucleic acid synthesis
466(2)
Other agents that affect DNA
468(1)
Inhibitors of cytoplasmic membrane function
468(1)
Urinary tract antiseptics
469(1)
Antituberculosis agents
469(1)
Antibacterial agents in practice
470(2)
Antibiotic assays
472(1)
Antiviral therapy
473(8)
Antifungal agents
481(2)
Antiparasitic agents
483(3)
Control by chemotherapy versus vaccination
486(1)
Control versus eradication
486(1)
Use and misuse of antimicrobial agents
487(3)
35 Protecting the host: vaccination
490(15)
Vaccination -- a four hundred year history
490(1)
Aims of vaccination
491(1)
Vaccines can be of different types
491(14)
36 Active, passive and adoptive immunotherapy
505(6)
Adoptive immunotherapy
505(1)
Passive immunotherapy
506(3)
Non-specific cellular immunostimulation
509(1)
Correction of host immunodeficiency
509(1)
Probiotics
509(2)
37 Infection control
511(18)
Common hospital infections
511(1)
Important causes of hospital infection
511(3)
Sources and routes of spread of hospital infection
514(1)
Host factors and hospital infection
515(1)
Consequences of hospital infection
515(1)
Prevention of hospital infection
516(3)
Investigating healthcare-associated infection
519(4)
Sterilization and disinfection
523(6)
Bibliography -- list of useful websites 529(2)
Index 531