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Molecular and Cellular Mechanobiology Softcover Reprint of the Original 1st 2016 ed. [Pehme köide]

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  • Formaat: Paperback / softback, 302 pages, kõrgus x laius: 235x155 mm, kaal: 4803 g, 57 Illustrations, color; 1 Illustrations, black and white; XIII, 302 p. 58 illus., 57 illus. in color., 1 Paperback / softback
  • Sari: Physiology in Health and Disease
  • Ilmumisaeg: 09-Jun-2018
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 1493981668
  • ISBN-13: 9781493981663
  • Pehme köide
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  • Formaat: Paperback / softback, 302 pages, kõrgus x laius: 235x155 mm, kaal: 4803 g, 57 Illustrations, color; 1 Illustrations, black and white; XIII, 302 p. 58 illus., 57 illus. in color., 1 Paperback / softback
  • Sari: Physiology in Health and Disease
  • Ilmumisaeg: 09-Jun-2018
  • Kirjastus: Springer-Verlag New York Inc.
  • ISBN-10: 1493981668
  • ISBN-13: 9781493981663
This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.
Part
1. Mechanosensors.- The Primary Cilium as a Strain Amplifying
Microdomain for Mechanotransduction at the Cell Membrane.- Vascular
Endothelial Mechanosensors in Response to Fluid Shear Stress.- Cadherins in
Mechanotransduction.- Perspectives of FRET Imaging to study Epigenetics
and Mechanobiology in the Nucleus.- Part
2. Transducers.- Emerging Roles of
YAP/TAZ in Mechanobiology.- Role of Rho GTPases in Mechanobiology.-
Illuminating Cell Adhesion: Modern Microscopy Approaches to Study
Integrin-Based Focal Adhesions.- Part
3. Epigenetic and Genetic Regulations
in the Nucleus.- Mechanotransduction to Epigenetic Remodeling.- The Nuclear
Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration.-
Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and
Gene Expression.- Part
4. Applications.- Mechanobiological Control of Cell
Fate for Applications in Cardiovascular Regenerative Medicine.- Heart Valve
Mechanobiology in Development and Disease.- Molecular and Cellular
Mechanobiology of Cancer.