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E-raamat: Molecular and Cellular Mechanobiology

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This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.
Part I Mechanosensors
1 The Primary Cilium as a Strain Amplifying Microdomain for Methanolransduction at the Cell Membrane
3(26)
Emily R. Moore
Christopher R. Jacobs
2 Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress
29(28)
Li-Jing Chen
Wei-Li Wang
Jeng-Jiann Chiu
3 Cadherins in Mechanotransduction
57(26)
D.E. Leckband
Part II Transducers
4 Emerging Roles of YAP/TAZ in Mechanobiology
83(14)
Yubing Sun
Yue Shao
Xufeng Xue
Jianping Fu
5 Role of Rho GTPases in Mechanobiology
97(22)
Christopher A. McCulloch
6 Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions
119(24)
Vinay Swaminathan
Clare M. Waterman
Part III Epigenetic and Genetic Regulations in the Nucleus
7 Perspectives of FRET Imaging to Study Epigenetics and Mechanobiology in the Nucleus
143(20)
Qin Peng
Binbin Cheng
Shaoying Lu
Shu Chien
Yingxiao Wang
8 Mechanotransduction to Epigenetic Remodeling
163(12)
Douglas Kelkhoff
Timothy Downing
Song Li
9 The Nuclear Lamina: From Mechanosensing in Differentiation to Cancer Cell Migration
175(22)
Jerome Irianto
Irena L. Ivanovska
Joe Swift
Dennis E. Discher
10 Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression
197(22)
Yejun Wang
Ekta Makhija
Karthik Damodaran
G.V. Shivashankar
Part IV Applications
11 Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine
219(36)
Andrew J. Putnam
12 Heart Valve Mechanobiology in Development and Disease
255(22)
Aileen Zhong
Craig A. Simmons
13 Molecular and Cellular Mechanobiology of Cancer
277(14)
Laurent Fattet
Jing Yang
Index 291