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Music of Life: Biology beyond genes [Pehme köide]

(Emeritus Professor of Cardiovascular Physiology at the University of Oxford)
  • Formaat: Paperback / softback, 176 pages, kõrgus x laius x paksus: 196x129x10 mm, kaal: 124 g, 7 black and white halftones
  • Ilmumisaeg: 14-Feb-2008
  • Kirjastus: Oxford University Press
  • ISBN-10: 0199228361
  • ISBN-13: 9780199228362
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  • Formaat: Paperback / softback, 176 pages, kõrgus x laius x paksus: 196x129x10 mm, kaal: 124 g, 7 black and white halftones
  • Ilmumisaeg: 14-Feb-2008
  • Kirjastus: Oxford University Press
  • ISBN-10: 0199228361
  • ISBN-13: 9780199228362
Teised raamatud teemal:
The gene's eye view of life, proposed in Richard Dawkins acclaimed bestseller The Selfish Gene, sees living bodies as mere vehicles for the replication of genetic codes. But in The Music of Life, world renowned physiologist Denis Noble argues that, to truly understand life, we must look beyond the "selfish gene" to consider life on a much wider variety of levels.
Life, Noble asserts, is a kind of music, a symphonic interplay between genes, cells, organs, body, and environment. He weaves this musical metaphor throughout this personal and deeply lyrical work, illuminating ideas that might otherwise be daunting to non-scientists. In elegant prose, Noble sets out a cutting-edge alternative to the gene's eye view, offering a radical switch of perception in which genes are seen as prisoners and the organism itself is a complex system of many interacting levels. In his more expansive view, life emerges as a process, the ebb and flow of activity in an intricate web of connections. He introduces readers to the realm of systems biology, a field that has been growing in strength in the past decade. Noble, himself one of the founders of this field, argues modern systems biology may be the view we need to adopt to gain a deeper understanding of the nature of life.
Drawing on his experiences in his research on the heartbeat, and on evolutionary biology, development, medicine, philosophy, linguistics, and Chinese culture, Noble presents us with a profound and very modern reflection on the nature of life.

Arvustused

Review from previous edition A beautifully written book... After the great successes of molecular biology, the time has come to re-assemble the organism. Denis Noble tells us why this needs to be done. He also tells us how we should go about it. Strongly recommended. * Sir Patrick Bateson, F.R.S., Emeritus Professor of Ethology, Cambridge * highly evocative essay * Steven Poole, The Guardian *

Introduction ix
1. The CD of Life: the Genome
1
Introducing the Silmans
1
DNA-mania
3
Problems with genetic determinism
6
Origin of the appeal of genetic determinism
11
Life is not a protein soup
15
Mapping the alternative metaphors
17
2. The Organ of 30,000 Pipes
23
The Chinese Emperor and the poor farmer
23
The genome and combinatorial explosion
27
An organ of 30 000 pipes
31
3. The Score: is it Written Down?
33
Is the genome the 'book of life'?
33
The French bistro omelette
35
The ambiguity of language
37
The Silmans return
39
4. The Conductor: Downward Causation
42
How is the genome played?
42
Is the genome a program?
43
Control of gene expression
46
Downward causation takes many forms
48
Other forms of downward causation
49
Where is the program of life?
51
5. The Rhythm Section: the Heartbeat and other Rhythms
55
Beginnings of biological computation
55
Reconstructing heart rhythm: the first attempt
56
The integrative level of heart rhythm
61
Systems biology is not 'vitalism' in disguise
65
Nor is it reductionism in disguise
65
Other natural rhythms
67
6. The Orchestra: Organs and Systems of the Body
74
Novartis Foundation debates
74
Problems with bottom-up
75
Problems with top-down
78
Middle-out!
79
The organs of the body
82
The virtual heart
83
7. Modes and Keys: Cellular Harmony
88
The Silmans find some tropical islands
88
The Silmans' mistake
92
Genetic basis of cell differentiation
93
Modes and keys
96
Multicellular harmony
97
A historical note on 'Lamarckism'
99
8. The Composer: Evolution
101
The Chinese writing system
101
Modularity in genes
103
Gene—protein networks
104
Fail-safe redundancy
106
Faustian pacts with the devil
109
The logic of life
111
The grand composer
112
9. The Opera Theatre: the Brain
113
How do we see the world?
114
At Aziz' restaurant
119
Action and will: a physiologist and a philosopher experiment
122
Explanatory shift between levels
125
The self is not a neural object
128
The deep-frozen brain
131
The resurrected self?
132
10. Curtain Call: the Artist Disappears 135
Jupitereans
135
Role of culture in our view of the self and the brain
137
The self as metaphor
141
The artist disappears
143
Bibliography 144
Index 147


Denis Noble, CBE, FRS, is Emeritus Professor of Cardiovascular Physiology at the University of Oxford. He was Chairman of the IUPS (International Union of Physiological Sciences) World Congress in 1993, and Secretary-General of IUPS from 1993-2001. His previous publications include the seminal set of essays The Logic of Life (Boyd and Noble, OUP 1993), and he played a major role in launching the Physiome Project, one of the international components of the systems biology approach. Science magazine included him amongst its review authors for its issue devoted to the subject in 2002.