This volume of Contributions to Nephrology is comprised of papers presented at the 7th International Ammoniagenesis Workshop. The presentations are organized into sections dealing with ammonia-forming enzymes, molecular biological aspects of glutamine metabolism metabolic alterations in acidosis, kidney and brain metabolism of glutamine and other amino acids, hepatic amino acid metabolism, renal utilization of various nitrogenous substances, and interorgan metabolism of ammonia and other substrates. With contributions from leading researchers, this book is a valuable update for scientists working or interested in the field.
Preface IX Ammonia-Forming Enzymes 1(24) Role of Hetero-Enzyme Complexes in Acid-Base Balance 1(10) Fahien, L. A. Din, Z. Laboy, J. Chobanian, M. C. (Madison, Wise.) Soluble and Membrane-Bound Forms of Phosphate-Activated Glutaminase with Different Kinetic Characteristics in Pig and Rat Kidney Mitochondria 11(8) Roberg, B. Torgner, I. A. Kvamme, E. (Oslo) The Increase in Glutamine Synthesis from Glucose Caused by Ammonium Chloride in Rabbit Kidney Tubules Does Not Involve an Increase in Citrate Synthesis 19(6) Chauvin, M. -F. (Lyon) Megnin-Chanet, F. Martin, G. Lhoste, J. -M. Baverel, G. (Orsay) Molecular Biological Aspects of Glutamine Metabolism 25(23) Stimulation of Phosphoenolpyruvate Carboxykinase Gene Expression in Cultured LLC-PK(1)-F(+) Cells 25(6) Drewnowska, K. (Richmond, Va.) Labruyere, W. T. van den Hoff, M. J. B. Lamers, W. H. (Amsterdam) Schoolwerth, A. C. (Richmond, Va.) A Novel Na(+)-Dependent Amino Acid Transporter with a High Affinity to Glutamine 31(6) Endou, H. Kanai, Y. Utsunomiya-Tate, N. Hosoyamada, M. (Tokyo) Effect of K(+) Depletion on Glutamate Dehydrogenase 37(6) Sastrasinh, S. (East Orange, N. J. Newark, N. J. Cheewatrakoolpong, B. (Kenilworth, N. J.) Chadha, I. (East Orange, N.J. Newark, N.J.) Sastrasinh, M. (East Orange, N.J.) Characterization of the Hepatic Glutaminase Promoter 43(5) Chung-Bok, M. -I. Watford, M. (New Brunswick, N.J.) Metabolic Alterations in Acidosis 48(21) Ensuring a Minimum Urine Flow Rate during Water Deprivation in Chronic Fasting 48(7) Halperin, M. L. (Toronto) Soroka, S. D. Gowrishankar, M. Kim, H. C. Myers, J. A. Rubin S. (Saskatoon) Role of Adrenal Steroids in Stimulating Ammonium Excretion during Acute Metabolic Acidosis 55(7) Nolan, P. J. (Washington, D.C.) Knepper, M. A. (Bethesda, Md.) Packer, R. K. (Washington, D.C.) Mechanism(s) Regulating Matrix pH in Rat Kidney Mitochondria 62(7) Drewnowska, K. Schoolwerth, A. C. (Richard, Va.) Kidney and Brain Metabolism of Glutamine and Other Amino Acids 69(24) An Overview of Mitochondrial Glutamine Transport and Phosphate-Activated Glutaminase in the Kidney 69(10) Kvamme, E. Roberg, B. Torgner, I. A. (Oslo) Renal Homocysteine Metabolism 79(6) House, J. D. Brosnan, M. E. Brosnan, J. T. (St. Johns) Metabolic Requirement for Inorganic Phosphate by Renal Proximal Tubules: Influence upon L-Glutamine Metabolism 85(8) Chobanian, M. C. Fahien, L. A. Brazy, P. C. (Madison, Wise.) Hepatic Amino Acid Metabolism 93(36) Hippurate as a Source of Renal and Hepatic Ammoniagenesis in Different Species 93(8) Malyusz, M. Rudolph, N. Barth A. Gronow, G. Malyusz, T. (Kiel) Regulation of Hepatic Protein Degradation 101(8) Blommaart, E. F. C. Luiken, J. J. F. P. Meijer, A. J. (Amsterdam) No Increase of Ornithine Concerntration in the Liver of Ornithine Trancarbamylase-Deficient spf-ash Mice following Intraperitoneal Injection of Ammonium Chloride 109(8) Saheki, T. Fukushige, T. Kakinoki, H. Kobayashi, K. (Kagoshima) Nitrogen Metabolism in Ammonium Chloride-Supplemented Rats During Protein Depletion 117(12) Lardner, A. L. ODonovan, D. J. (Galway) Renal Utilization of Various Nitrogenous Substance 129(20) How Does the Kidney Handle Plasma Polyamines? 129(7) Brosnan, M. E. Ray, S. Walters, B. Pink, D. (St. Johns) Oxidation of Glutamine in Cancer Cells and Regeneration of Adenylates via Adenylosuccinate Synthetase 136(7) Kovacevic, Z. Brkljac, O. Oros, J. (Novi Sad) Leucine Metabolism and Protein Dynamics in the Human Kidney 143(6) Garibotto, G. (Genoa) Tessari, P. (Padova) Robaudo, C. (Genoa) Vettore, M. (Padova) Saffioti, S. (Genoa) Zanetti, M. (Padova) Sofia, A. Deferrari, G. Tizianello, A. (Genoa) Interorgan Metabolism of Ammonia and Other Substrates 149(19) Defective Glycolysis and Catabolism of Protein and Amino Acids in Skeletal Muscle during Metabolic Acidosis 149(7) Bevington, A. Walls, J. (Leicester) Incorporation of (15)N-Labelled Precursors into Urea Isotopomers 156(7) Brosnan, J. T. Brosnan, M. E. Charron, R. (St. Johns) Nissim, I. (Philadelphia, Pa.) RT-PCR Localization of Phosphoenolpyruvate Carboxykinase in the Proximal Tubule of the Rat during Metabolic Acidosis 163(5) Craig, M. R. DiGiovanni, S. R. Drewnowska, K. Schoolwerth, A. C. (Richmond, Va.) Author Index 168(1) Subject Index 169
