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Polyphenols: Mechanisms of Action in Human Health and Disease 2nd edition [Kõva köide]

Edited by (Professor, Department of Clinical Biochemistry, Kings College Hospital, London), Edited by , Edited by (Professor, Mel and Enid Zuckerman College of Public Health and School of Medicine, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA)
  • Formaat: Hardback, 470 pages, kõrgus x laius: 276x216 mm, kaal: 1500 g
  • Ilmumisaeg: 08-Aug-2018
  • Kirjastus: Academic Press Inc
  • ISBN-10: 0128130067
  • ISBN-13: 9780128130063
Teised raamatud teemal:
  • Formaat: Hardback, 470 pages, kõrgus x laius: 276x216 mm, kaal: 1500 g
  • Ilmumisaeg: 08-Aug-2018
  • Kirjastus: Academic Press Inc
  • ISBN-10: 0128130067
  • ISBN-13: 9780128130063
Teised raamatud teemal:

Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system. They are a unique group of phytochemicals that are present in all fruits, vegetables and other plant products.

This very diverse and multi-functional group of active plant compounds contain powerful antioxidant properties and exhibit remarkable chemical, biological and physiological properties, including cancer prevention and cardio-protective activities.

  • Expands coverage on green tea, cocoa, wine, cumin and herbs
  • Outlines their chemical properties, bioavailability and metabolomics
  • Provides a self-teaching guide to learn the mechanisms of action and health benefits of polyphenols
Contributors xi
Preface xv
Acknowledgments xvii
I OVERVIEW OF POLYPHENOLS AND HEALTH
1 Polyphenols in the Prevention of Acute Pancreatitis in Preclinical Systems of Study: A Revisit
3(8)
Elroy Saldanha
Suresh Rao
Mohammed Adnan
Michael L.J. Pais
Taresh Shekar Naik
Ritesh D'cunha
Reshmina D'souza
Manjeshwar Shrinath Baliga
1 Introduction
3(1)
2 Curcumin
4(1)
3 Resveratrol
5(1)
4 Quercetin
5(1)
5 Genistein
6(1)
6 Ellagic Acid
6(1)
7 Cinnamtannin B-l
6(1)
8 Green Tea Polyphenols
7(1)
9 Conclusions and Future Directions
7(4)
References
8(1)
Further Reading
9(2)
2 Polyphenols as Supplements in Foods and Beverages: Recent Discoveries and Health Benefits, an Update
11(8)
Andrea Pittelli Boiago Gollucke
Rogerio Correa Peres
Daniel Araki Ribeiro
Odair Aguiar
1 Polyphenols and Supplementation
11(1)
2 New Insights on Polyphenol Metabolism and Action
12(1)
3 Benefits of Polyphenol's Consumption: Experimental Data
13(1)
4 Antimicrobial Activity of Polyphenols
14(1)
5 Noxious Activities Induced by Polyphenols: An Intriguing Issue
15(1)
6 Concluding Remarks and Future Challenges
16(3)
References
16(3)
3 Xanthohumol and the Medicinal Benefits of Beer
19(14)
Susan M. Elrod
1 Introduction
19(1)
2 History of Beer and Brewing
19(1)
3 Styles
20(1)
4 Ingredients
21(2)
5 Health Benefits of Beer Polyphenols: Xanthohumol
23(6)
6 Summary
29(4)
References
30(2)
Glossary
32(1)
4 Polyphenols Flavonoids and Metalloprotease Inhibition: Applications to Health and Disease
33(8)
Dejan Agio
Marija Abramic
Vesna Rastija
Rosemary Vukovic
1 Introduction
33(1)
2 Matrix Metalloproteinases
34(2)
3 Angiotensin-Converting Enzyme
36(2)
4 Conclusion
38(3)
References
38(3)
5 Biological and Pharmacological Effects of Polyphenolic Compounds From Ecklonia cava
41(12)
Akiko Kojima-Yuasa
1 Introduction
41(1)
2 Biological and Pharmacological Effects of Phlorotannins From E. cava
41(6)
3 Protective Effect Against Ethanol-Induced Liver Injury
47(2)
4 AMPK in the Protective Effects of Phlorotannins
49(1)
5 Conclusion
50(3)
References
50(3)
6 Clerodeiidrum volub&e: Phenolics and Applications to Health
53(16)
Ochuko L. Erukainure
Olakunle Sanni
Md. Shahidul Islam
1 Introduction
53(1)
2 Phenolics and Elealth
53(1)
3 Phytochemistry of Ckrodendrum volubite
54(3)
4 Biological Activities of Ckrodendrum voiubik
57(8)
5 Proposed Mechanism of Action of C. voiubik
65(1)
6 Conclusion
65(4)
Acknowledgments
66(1)
References
66(3)
7 Eryngium campestre L: Polyphenolic and Flavonoid Compounds; Applications to Health and Disease
69(12)
Bouzidi Soumia
1 Introduction
69(1)
2 About the Plant
70(1)
3 Distribution
70(1)
4 Traditional Uses
70(2)
5 Phytochemistry
72(2)
6 Biological and Pharmacological Activities
74(3)
7 Conclusion
77(4)
References
77(4)
8 Antioxidant Activity of Anthocyanins in Common Legume Grains
81(12)
Winda Christina Harlen
Ignasius Radix A.P. Jati
1 Introduction
81(1)
2 Free Radicals and Antioxidants
81(1)
3 Anthocyanins
82(1)
4 Legume Anthocyanin as Antioxidant
82(8)
5 Conclusion
90(3)
References
90(3)
9 Tomato Polyphenolics: Putative Applications to Health and Disease
93(10)
Sena Bakir
Senem Kamiloglu
Merve Tomas
Esra Capanoglu
1 Introduction
93(1)
2 Health Effects of Tomato Phenolics
94(5)
3 Concluding Remarks
99(4)
References
100(3)
10 Polyphenols Compounds in Sweet Cherries: A Focus on Anthocyanins
103(16)
Katherine Kent
Nadine Holzel
Nigel Swarts
1 An Overview of the Nutritive and Nonnutritive Properties of Sweet Cherries
103(1)
2 A Focus on Anthocyanins in Sweet Cherries
104(1)
3 Anthocyanin Biosynthesis in Sweet Cherries
105(1)
4 Measurement of Anthocyanin Content in Sweet Cherries
106(1)
5 Pre- and Postharvest Factors That Impact on Anthocyanins in Sweet Cherries
106(1)
6 Patterns of Global Growth and Economic Importance of Sweet Cherry Production
107(2)
7 Important Sensory Attributes and Traditional Quality Indicators of Sweet Cherries
109(1)
8 Consumer Preference for Sweet Cherries May Not Be Driven by Health
110(1)
9 Sweet Cherry Consumption and Contribution to Habitual Anthocyanin Consumption
111(1)
10 Sweet Cherries and Health Outcomes: Potential Mechanisms of Action
112(3)
11 Conclusion: Major Gaps in Literature and Future Research Direction
115(4)
Acknowledgments
116(1)
References
116(3)
11 Citrus Fruit Polyphenols and Flavonoids: Applications to Psychiatric Disorders
119(16)
Maria Rosaria Anna Muscatello
Rocco Antonio Zoccali
Antonio Bruno
1 Introduction
119(1)
2 The Global Burden of Mental Illness
119(1)
3 Moving Toward Integrative Prevention and Care: The Link Between Nutrition and Mental Health
120(1)
4 Citrus Polyphenols and Flavonoids
121(2)
5 Citrus Polyphenols in Mental Disorders
123(5)
6 Conclusions and Future Directions
128(7)
References
129(6)
II Polyphenols In Therapy Of Obesity And Diabetes
12 Anthocyanins and Diabetes Regulation
135(12)
Honghui Guo
Min Xia
1 Introduction
135(1)
2 Chemical Properties of Anthocyanins
135(2)
3 Dietary Anthocyanin Sources
137(1)
4 Anthocyanin Bioavailability
137(1)
5 Antidiabetic Effects of Anthocyanins and the Underlying Mechanisms
138(4)
6 Conclusion and Perspective
142(5)
Acknowledgments
143(1)
References
143(4)
13 The Role of Direct and Indirect Polyphenols Antioxidants in Protection Against Oxidative Stress
147(34)
Lars Porskjær Christensen
1 Introduction
147(2)
2 Cytoprotective Proteins (Phase 2 Enzymes)
149(1)
3 Induction of Cytoprotective Proteins
150(1)
4 Direct and Indirect Antioxidants and Their Role in Protection Against Oxidative Stress
150(2)
5 Polyphenol and Polyphenol-Derived Inducers ot Cytoprotective Proteins (Indirect Antioxidant Effect)
152(18)
6 Conclusions
170(11)
References
171(10)
14 Role of Protocatechuic Acid in Obesity-Related Pathologies: An Update
181(12)
Massimo D'Archivio
Beatrice Scazzocchio
Annalisa Silenzi
Claudio Giovannini
Roberta Masella
1 Introduction
181(1)
2 Protocatechuic Acid: Food Content and Bioavailability
181(1)
3 Obesity: A Global Challenge Yet Today
181(3)
4 Mechanism of Action of PCA
184(5)
5 Conclusion
189(4)
References
189(4)
15 Exposure to Polyphenols Compounds Modulates Type I Diabetes: The Case of Genistcin
193(14)
Guannan Huang
Joella Xu
Tail Guo
1 Introduction
193(1)
2 Pathogenesis of T1D
193(1)
3 Polyphenolic Compounds and TID
194(2)
4 Mechanisms of T1D Modulation by Polyphenolic Compounds: Gut Microbiota
196(3)
5 Mechanisms of T1D Modulation by Polyphenolic Compounds: Epigenetics
199(1)
6 Other Potential Mechanisms
200(1)
7 Conclusion
200(7)
Acknowledgments and Funding Support
200(1)
References
200(7)
III Mechanisms Of Polyphenols Antioxidant Effects
16 Chocolate/Cocoa Polyphenols and Oxidative Stress
207(14)
Judith E. Allgrove
Glen Davison
1 Introduction
207(1)
2 Antioxidant Properties
207(1)
3 Bioavailability
208(1)
4 Research on Cocoa and Oxidative Stress
208(8)
5 Summary
216(5)
References
217(4)
17 An Overview of Dietary Polyphenols and Their Therapeutic Effects
221(16)
Pallavi Kesavan
Antara Banerjee
Anushka Banerjee
Ramachandran Murugesan
Francesco Marotta
Surajit Pathak
1 Introduction
221(1)
2 Structural Classification of Polyphenols
221(3)
3 Dietary Intake and Content of Polyphenols
224(1)
4 Bioavailability and Distribution of Polyphenols
225(1)
5 Epigenetic Modifications and Polyphenol Metabolism
226(2)
6 Nutritional Genomics and Dietary Polyphenols
228(4)
7 Novel Therapeutics Using Polyphenols
232(5)
Acknowledgments
232(1)
References
232(3)
Further Reading
235(2)
18 The Polyphenolic Compound Resveratrol Attenuates Pain: Neurophysiological Mechanisms
237(12)
Mamoru Takeda
Shiori Takehana
Yoshihito Shimazu
1 Introduction
237(1)
2 Classification of Pain
238(1)
3 Pain Pathway in the Trigeminal System
238(1)
4 Modulatory Mechanism of Resveratrol on the Nociceptive Pain
239(2)
5 Modulatory Mechanism Underlying the Effect of Resveratrol on Pathological Pain
241(2)
6 Functional Significance for Modulation of Pain Relief
243(1)
7 Future Direction
244(1)
8 Concluding Remarks
245(4)
References
245(4)
19 Possible Benefits and Risks of Polyphenols Supplementation During Pregnancy
249(12)
Antonio Gonzalez-Bulnes
Susana Astiz
Beatriz Isabel
Marta Vazquez-Gomez
Consolacion Garcia-Contreras
Outline
249(1)
1 Introduction
249(1)
2 The Role of Intrauterine Environment in Pregnancy Development
250(1)
3 The Role of the Intrauterine Environment in Postnatal Traits
250(1)
4 Preventive Strategies and Therapies for IUGR
251(1)
5 Alternative Tools for Prevention and Treatment of IUGR: Amino Acids and Antioxidants
252(1)
6 Implications and Evidence for Beneficial Effects of Polyphenols Supplementation During Pregnancy
253(2)
7 Possible Risks of Polyphenols Supplementation During Pregnancy
255(1)
8 Concluding Remarks and Future Research
256(5)
Acknowledgments
256(1)
References
256(5)
20 Flavonoids as Modulators of Neutrophils' Oxidative Burst: Structure-Activity Relationship
261(16)
Daniela Ribeiro
Eduarda Fernandes
Marisa Freitas
1 Introduction
261(1)
2 Neutrophils Morphology
261(1)
3 Neutrophil Phagocytosis
262(1)
4 Production of Reactive Oxygen Species
262(2)
5 Production of Reactive Nitrogen Species
264(1)
6 Flavonoids
265(1)
7 Effect of Flavonoids on Neutrophils'Oxidative Burst
266(6)
8 Catechol Group in the B-Ring
272(1)
9 3-OH in the C-Ring
273(1)
10 C2-C3 Double Bond
274(1)
11 Conclusion
274(3)
Acknowledgments
274(1)
References
274(3)
21 Manipulation of Mitochondrial Function by Polyphenols for New Treatment Strategies
277(18)
Corina T. Madreiter-Sokolowski
Wolfgang F. Graier
1 Introduction
277(1)
2 Mitochondria
278(2)
3 Polyphenols
280(1)
4 Manipulation of Mitochondrial Function by Polyphenols
281(3)
5 Polyphenols as Treatment Strategies to Manipulate Mitochondrial (Dys)Function in Diseases
284(3)
6 Conclusion
287(8)
References
288(4)
Glossary
292(3)
IV Bioavailability And Effects On Metabolism
22 Bioavailability of Flavonoids: The Role of Cell Membrane Transporters
295(26)
Jovana Cvorovic
Lovro Ziberna
Stefano Fornasaro
Federica Tramer
Sabina Passamonti
1 Introduction
295(1)
2 Principles of Membrane Transport
296(1)
3 Indirect Evidence Supporting the Existence of Flavonoid Membrane Transporters
297(4)
4 Anatomical Distribution of Flavonoid-Related Membrane Transporters
301(9)
5 Issues Related to the Low Bioavailability of Flavonoids
310(1)
6 Transporter-Based Flavonoid-Drug Interactions
311(1)
7 Conclusion
312(9)
Acknowledgments
313(1)
References
313(8)
23 Interaction of Polyphenols With the Intestinal and Placental Absorption of Some Bioactive Compounds
321(16)
Elisa Keating
Conceicao Calhau
Ana Faria
Fatima Martel
1 Introduction
321(1)
2 Effect of Polyphenols on the Transport of l-Methyl-4-Phenylpyridinium
322(2)
3 Effect of Polyphenols on the Transport of Folates
324(2)
4 Effect of Polyphenols on the Transport of Thiamine
326(2)
5 Effect of Polyphenols on the Transport of Glucose
328(4)
6 Conclusions
332(5)
References
332(5)
24 Analyzing Ingredients in Dietary Supplements and Their Metabolites
337(10)
Jeevan K. Prasain
Stephen Barnes
J. Michael Wyss
1 Introduction
337(1)
2 Anthocyanins
338(1)
3 Flavanols
339(1)
4 Flavones and Flavonols
340(1)
5 Isoflavones
340(2)
6 Extraction of Isoflavones
342(2)
7 In Vivo Metabolism of Isoflavones
344(1)
8 Conclusions
345(2)
References
345(2)
25 Metabolism of Dietary Polyphenols by Human Gut Microbiota and Their Health Benefits
347(14)
Surajit Pathak
Pallavi Kesavan
Anushka Banerjee
Antara Banerjee
Gulcin Sagdicoclu Celep
Laura Bissi Francesco Marotta
1 Introduction
347(2)
2 Dietary Intake of Polyphenols
349(1)
3 Absorption, Metabolism, and Bioavailability of Polyphenols
349(1)
4 Metabolism of Polyphenols by the Gut Microbiota
350(3)
5 Enzymes in the Metabolism of Polyphenols
353(1)
6 Modulation of Gut Microbiota by Polyphenols
353(1)
7 Health Benefits of Polyphenols and Their Microbial Metabolites
354(1)
8 Conclusions
355(6)
Acknowledgments
356(1)
References
356(5)
26 Bioavailability and Biochemistry of Quercetin and Applications to HeaLth and Diseases
361(12)
Gabriele Carullo
Mariateresa Badolato
Francesca Alello
1 Chemical Features of Quercetin
361(1)
2 Bioavailability, Absorption and Metabolism of Quercetin
362(2)
3 Mechanistic and Preclinical Studies of Quercetin and Its Metabolites
364(1)
4 Esters of Quercetin and Their Therapeutic Applications
365(2)
5 Conclusion
367(6)
References
368(3)
Further Reading
371(2)
27 Effects of Quercetin and Its Combinations on Health
373(24)
S.K. Shebeko
L.A. Zupanets
O.S. Popov
O.O. Tarasfnko
A.S. Shalamay
1 Introduction
373(1)
2 Basic Pharmacological Properties of Quercetin
374(2)
3 Pharmacokinetic Properties of Quercetin and Ways al Modifying Them
376(1)
4 Gastroprotective Effects of Quercetin
377(2)
5 Angioprotective Activity ol Quercel in
379(1)
6 Effects of Quercetin on Hemostasia
379(1)
7 Cardioprotective Properties of Quercetin
380(2)
8 Application of Quercetin-Based Drugs in Chronic Kidney Disease
382(4)
9 Quercetin-Based Drugs in Joint Disease
386(5)
10 Conclusion
391(6)
References
392(5)
V Polyphenols In Disease
28 Green Tea Polyphenols in the Amelioration of Osteoarthritis: Memoir on the Preclinical Observations
397(6)
Naveen Joseph Mathai
Davanagere Murali Sujayendra
Mohammed Adnan
Taresh Shekar Naik
Thomas George
Soniya Abraham
Manjeshwar Shrinath Baliga
1 Introduction
397(1)
2 Green Tea in Arthritis
398(1)
3 Phytochemistry of Green Tea
398(1)
4 Traditional and Validated Uses
399(1)
5 Free Radical Scavenging and Antioxidant Properties
399(1)
6 Green Tea Increases Antioxidant Enzymes and Reduces Lipid Peroxidation
399(1)
7 Antiinflammatory Effects
399(1)
8 Green Tea Polyphenols Inhibit the Activation of Mitogen-Activated Protein Kinases
400(1)
9 Green Tea and Its Polyphenols Decrease Activation of NF-kB
400(1)
10 EGCG and Its Influence on Matrix Metalloproteinases
400(1)
11 Chondroprotective Effects of EGCG
400(1)
12 EGCG Inhibits Osteoclast Activation and Differentiation
401(1)
13 Conclusion
401(2)
References
401(2)
29 Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers
403(12)
Russell Jaffe
Jayashree Mani
1 Polyphenolic Consumption
403(1)
2 Flavanoids and Flavonols
404(1)
3 Measurements of Antioxidant Capacity
404(2)
4 Quercetins
406(1)
5 Synergistic Polyphenols: Quercetin Dihydrate and Soluble Orthoproanthocyanidin
406(2)
6 Orthoproanthocyanidins (Soluble OPCs)
408(1)
7 Ellagic Acid Content: Pomegranate Juice
409(1)
8 Clinical Considerations: Whole Fruit and Fruit Juice
409(1)
9 Predictive Biomarkers Referenced to Goal Values: Personalized Care
410(1)
10 Conclusions
411(4)
References
412(3)
30 Hepatoprotective Effects of Green Tea and Its Polyphenols: A Revisit
415(6)
Manjeshwar Shrinath Baliga
Arnadi Ramachandrayya Shiv Ash Ankara
Paul Simon
Suresh Rao
Princy Louis Palatty
1 Introduction
415(1)
2 Tea Protects Against Alcohol-Induced Hepatotoxicity
415(1)
3 Tea Protects Against Carbon Tetrachloride-lnduced Hepatotoxicity
416(1)
4 Effect of Tea on N-Acctammophcn-Induced Hepatotoxicity
416(1)
5 Tea Is Effective in Viral Hepatitis
417(1)
6 Effect of Tea on Ischemia Reperfusion Injury
417(1)
7 Effect of Green Tea Phytochemicals on Hepatotoxicity of Lead
417(1)
8 Effect of Tea Phytochemicals on Hepatotoxicity of Azathioprine
417(1)
9 Effect of Tea Phytochemicals on Galactosaniine-lnduced Liver Damage
417(1)
10 Effect of Tea Phytochemicals on Lipopolysaccharide-Induced Liver Damage
417(1)
11 Effect of Tea Phytochemicals on Fumonisin B1-Induced Liver Damage
418(1)
12 Effect of Tea on Hepatotoxicity of Aflatoxins
418(1)
13 Effect of Tea Phytochemicals on Phenobarbitol-Induced Liver Damage
418(1)
14 Effect of Tea on Hepatocarcinogenesis
418(1)
15 Effect of Tea Polyphenols on Fatty Liver Disease
419(1)
16 Effect of Tea Polyphenols on Obesity-Induced Liver Damage
419(1)
17 Conclusions
419(2)
References
419(2)
31 CAPE and Tympanosclerosis
421(10)
Ibrahim Agri
Arzu Erdal Agri
Dogukan Ozdemir
Abdulkadir Ozgur
1 The Effect of Caffeic Acid Penethyl Ester on Tympanosclerosis
421(1)
2 Caffeic Acid Phenethyl Ester
421(1)
3 CAPE and Oxidative Stress
422(1)
4 CAPE and Inflammation
423(1)
5 Tympanosclerosis
423(4)
6 CAPE and Tympanosclerosis
427(4)
References
428(2)
Further Reading
430(1)
32 The Polyphenolic Compound Hesperidin and Bone Protection
431(10)
Jenalyn L. Yumol
Wendy E. Ward
1 Introduction
431(1)
2 Nutrition as a Strategy for Maintaining Healthy, Strong Bones
432(1)
3 Hesperidin Consumption and Its Effect on Outcomes of Bone Protection
433(5)
4 Summary
438(3)
References
438(2)
Glossary
440(1)
Index 441
Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watsons career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at Kings College Hospital and Emeritus Professor of Nutritional Biochemistry at Kings College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at Kings College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books. Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadis research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.