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Protein Structure: Determination, Analysis, and Applications for Drug Discovery [Pehme köide]

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  • Formaat: Paperback / softback, 576 pages, kõrgus x laius: 229x152 mm, kaal: 453 g
  • Ilmumisaeg: 29-Oct-2019
  • Kirjastus: CRC Press
  • ISBN-10: 0367395347
  • ISBN-13: 9780367395346
Teised raamatud teemal:
  • Formaat: Paperback / softback, 576 pages, kõrgus x laius: 229x152 mm, kaal: 453 g
  • Ilmumisaeg: 29-Oct-2019
  • Kirjastus: CRC Press
  • ISBN-10: 0367395347
  • ISBN-13: 9780367395346
Teised raamatud teemal:
This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.
Preface v
Contributors xi
Part I Introduction
1 Structural Biology and Structural Genomics: A Federal Agency Perspective
1(8)
John C. Norvell
Marvin Cassman
Part II Determination
2 Producing Proteins
9(18)
Aled M. Edwards
Cheryl H. Arrowsmith
Raymond Hui
Fabien Marino
Alexei Savchenko
Ken Yamazaki
Adelinda Yee
3 Crystallization of Membrane Proteins
27(28)
R. Michael Garavito
4 Prospects for High-Throughput Structure Determination by X-Ray Crystallography
55(40)
Frank von Delft
Charles D. Rang
Duncan E. McRee
5 Prospects for High-Throughput Structure Determination of Proteins by NMR Spectroscopy
95(46)
Ann E. Ferentz
6 Automated Molecular Replacement
141(26)
Jorge Navaza
Pedro M. Alzari
7 Comparative Protein Structure Modeling
167(40)
Andras Fiser
Andrej Sali
8 Rising Accuracy of Protein Secondary Structure Prediction
207(44)
Burkhard Rost
9 Novel Fold and Ab Initio Methods for Protein Structure Generation
251(26)
David J. Osguthorpe
Part III Analysis
10 Identifying Errors in Three-Dimensional Protein Models
277(38)
Brian D. Marsden
Ruben A. Abagyan
11 Comparative Analysis and Evolutionary Classification of Protein Structures
315(34)
Liisa Holm
12 Automated Genome Functional Annotation for Structural Genomics
349(20)
Sophia Tsoka
Christos A. Ouzounis
13 The Importance of Structure-Based Function Annotation to Drug Discovery
369(20)
Susan M. Baxter
Stacy Knutson
Jacquelyn S. Fetrow
14 The Protein Data Bank
389(18)
Helen M. Berman
Philip E. Bourne
John Westbrook
Christine Zardecki
15 The European Bioinformatks Institute Macromolecular Structure Database (E-MSD)
407(10)
Dimitris Dimitropoulos
Peter A. Keller
Kim Henrick
John Ionides
Eugene Krissinel
Philip McNeil
Sameer S. Velankar
Part IV Applications for Drug Discovery
16 Molecular Docking in Structure-Based Design
417(36)
Trevor W. Heritage
17 Use of Pharmacophores in Structure-Based Drug Design
453(30)
Omoshile Clement
Adrea T. Mehl
18 The Structure of Human Interferon--la (Avonex®) and its Relation to Activity: A Case Study of the Use of Structural Data in the Arena of Protein Pharmaceuticals
483(38)
Adrian Whitty
Michael Karpusas
19 G-Protein-Coupled Receptors: Diverse Functions and Shared Mechanisms of Action Interpreted Through the Structure of Rhodopsin
521(40)
S. Roy Kimura
Daniel I. Chasman
20 Functional Assessment of Amino Acid Variation Caused by Single-Nucleotide Polymorphisms: A Structural View
561(32)
Daniel I. Chasman
Index 593
Daniel I. Chasman