Organized into four sections, the book covers an introductory chapter on structural genomics; methods for producing proteins in structural studies, experimental approaches for solving structures by crystallography and NMR, and computational strategies for determining structural information; analysis, mostly computational, for understanding proteins from their structures and descriptions of the database repositories of protein structures and the standards used to curate them; and potential uses of protein structure in the drug discovery process. The last section also address structure- based drug design, refining protein pharmaceuticals using structure, and the impact of genetic variation on protein function and pharmacology. Suitable as a reference for the researcher with basic knowledge of protein structure interested in determining, analyzing, and using structural information, particularly in conjunction with a genomics perspective. Annotation (c) Book News, Inc., Portland, OR (booknews.com)
This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.
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