Contributors |
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ix | |
About the Editors |
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xi | |
About the Series Editor |
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xiii | |
Aims and Scope for Series "Cancer Sensitizing Agents for Chemotherapy" |
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xv | |
Preface |
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xvii | |
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1 Pathways Linked to Cancer Chemoresistance and Their Targeting by Nutraceuticals |
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1 | (30) |
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1 | (1) |
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2 | (1) |
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3 | (4) |
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Chemoresistance: Problem in Curing Cancer |
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7 | (1) |
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Mechanism of Chemoresistance |
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8 | (6) |
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Chemosensitization: An Approach to Target Cancer |
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14 | (1) |
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Nutraceuticals as Chemosensitizers: Opportunities and Challenges |
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14 | (5) |
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19 | (1) |
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19 | (1) |
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19 | (1) |
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19 | (12) |
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2 The Potential of Curcumin: A Multitargeting Agent in Cancer Cell Chemosensitization |
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31 | (30) |
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Ajaikumar B. Kunnumakkara |
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31 | (1) |
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31 | (2) |
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Chemosensitization Studies of Curcumin in Different Cancers |
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33 | (18) |
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51 | (1) |
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52 | (1) |
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52 | (1) |
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52 | (8) |
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60 | (1) |
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3 Role of Resveratrol in Chemosensitization of Cancer |
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61 | (16) |
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61 | (1) |
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61 | (1) |
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Source and Chemistry of Resveratrol |
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62 | (1) |
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Possible Molecular Mechanisms of Chemoresistance in Cancer |
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62 | (3) |
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Chemosensitization Studies Using Resveratrol in Vitro |
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65 | (3) |
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Chemosensitization Studies Using Resveratrol in Vivo |
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68 | (2) |
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Human Clinical Trials Involving Resveratrol in Cancer |
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70 | (1) |
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Conclusion and Future Perspective |
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71 | (1) |
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71 | (5) |
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76 | (1) |
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4 Role of Tocotrienols in Chemosensitization of Cancer |
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77 | (22) |
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77 | (1) |
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77 | (1) |
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Source and Chemistry of Tocotrienols |
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78 | (1) |
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Molecular Targets of Tocotrienols in Cancer |
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79 | (2) |
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Mechanisms of Anticancer Action of Tocotrienols |
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81 | (2) |
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Chemosensitization by Tocotrienols |
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83 | (2) |
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Chemosensitization In Vitro |
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85 | (5) |
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Chemosensitization In Vivo |
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90 | (1) |
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Chemosensitization in Human |
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91 | (1) |
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91 | (1) |
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91 | (8) |
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5 Chemosensitization by Ursolic Acid: A New Avenue for Cancer Therapy |
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99 | (12) |
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99 | (1) |
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99 | (2) |
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Chemosensitization of Cancer Cells |
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101 | (5) |
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106 | (1) |
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Conclusion and Future Direction |
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106 | (1) |
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107 | (1) |
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107 | (4) |
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6 Role of Fisetin in Chemosensitization |
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111 | (30) |
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111 | (1) |
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112 | (1) |
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Chemistry and Sources of Fisetin |
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113 | (2) |
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Molecular Targets of Fisetin |
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115 | (11) |
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Chemosensitization by Fisetin |
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126 | (7) |
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133 | (1) |
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134 | (1) |
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134 | (7) |
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7 Role of Celastrol in Chemosensitization of Cancer |
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141 | (10) |
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141 | (1) |
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141 | (1) |
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Biological Source of Celastrol and Its Chemistry |
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142 | (1) |
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Molecular Targets of Celastrol and Its Potential Mechanism(s) of Action |
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143 | (2) |
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Anticancer and Chemosensitizing Effects of Celastrol |
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145 | (3) |
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148 | (1) |
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148 | (1) |
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148 | (1) |
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148 | (3) |
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8 Role of Gambogic Acid in Chemosensitization of Cancer |
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151 | (18) |
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151 | (1) |
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151 | (4) |
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Source and Chemistry of GA |
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155 | (1) |
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155 | (4) |
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Chemo-Sensitization by GA |
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159 | (2) |
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161 | (1) |
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161 | (8) |
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9 Role of Catechins in Chemosensitization |
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169 | (30) |
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169 | (2) |
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171 | (1) |
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172 | (1) |
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Structure and Chemistry of Catechins |
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173 | (4) |
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Molecular Targets of the Catechin |
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177 | (5) |
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Chemosensitization in Vitro |
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182 | (4) |
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Chemosensitization in Vivo |
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186 | (2) |
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188 | (1) |
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Implication of Catechins in Other Diseases |
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189 | (3) |
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192 | (1) |
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193 | (1) |
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193 | (1) |
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193 | (5) |
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198 | (1) |
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10 Anticancer Attributes of Silibinin: Chemo- and Radiosensitization of Cancer |
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199 | (22) |
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199 | (1) |
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200 | (2) |
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Structural Composition and Bioavailability of Silymarin/Silibinin |
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202 | (1) |
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Targeting of Various Attributes of Cancer Growth and Progression |
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203 | (7) |
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Silibinin as Chemosensitizer for Cancer Cells |
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210 | (3) |
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Silibinin as Radiosensitizer for Cancer Cells |
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213 | (1) |
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214 | (1) |
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215 | (6) |
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11 Berberine as an Adjuvant and Sensitizer to Current Chemotherapy |
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221 | (20) |
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221 | (1) |
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222 | (1) |
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222 | (1) |
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Evidence Showing the Potential of Berberine as a Chemosensitizer |
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223 | (9) |
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Hormetic Effects of Berberine in In Vitro Studies |
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232 | (1) |
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Chemosensitization In Vivo and Other Beneficial Properties |
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232 | (1) |
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Berberine in Human Trials |
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233 | (1) |
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234 | (1) |
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235 | (1) |
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235 | (1) |
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235 | (6) |
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12 Role of Emodin in Chemosensitization of Cancer |
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241 | (18) |
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241 | (2) |
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243 | (1) |
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Anti-cancer Activities of Emodin |
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243 | (6) |
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Anti-cancer Activities of Emodin Analogues |
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249 | (1) |
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Chemosensitization of Tumors by Emodin |
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250 | (4) |
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254 | (1) |
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255 | (1) |
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255 | (4) |
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13 Role of Piperine in Chemoresistance |
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259 | (28) |
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259 | (1) |
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259 | (1) |
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Sources and Chemistry of Piperine |
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260 | (1) |
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Piperine Extraction and Quantification |
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261 | (1) |
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Medicinal & Pharmacological Activities of Piperine |
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262 | (2) |
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Mechanism of Action of Piperine |
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264 | (6) |
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Chemoresistance and Chemosensitisation |
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270 | (5) |
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Interactions of Piperine With Chemotherapeutic Drugs |
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275 | (4) |
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279 | (1) |
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280 | (6) |
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286 | (1) |
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14 Role of Deguelin in Chemoresistance |
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287 | (10) |
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287 | (1) |
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287 | (1) |
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Source and Chemistry of Deguelin |
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288 | (1) |
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Molecular Targets of Deguelin |
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288 | (1) |
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Chemosensitization by Deguelin |
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288 | (4) |
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292 | (1) |
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293 | (1) |
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294 | (3) |
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15 Garcinol: Preclinical Perspective Underpinning Chemo- and Radiosensitization of Cancer |
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297 | (28) |
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297 | (1) |
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297 | (2) |
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299 | (1) |
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Garcinol: Therapeutic Targets |
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299 | (11) |
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Systemic Anticancer and Chemo-Sensitizing Effects of Garcinol |
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310 | (8) |
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Garcinol and TRAIL Sensitization |
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318 | (1) |
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Garcinol and Radiosensitization |
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319 | (1) |
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Garcinol Combination With Other Natural Agents' on Cancer Therapy |
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319 | (1) |
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320 | (1) |
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320 | (5) |
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16 Chemopreventive and Anticancer Effects of Plumbagin: Novel Mechanism(s) via Modulation of Cellular Redox |
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325 | (18) |
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Raghavendra S. Patwardhan |
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325 | (1) |
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325 | (2) |
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Occurrence and Isolation of Plumbagin |
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327 | (1) |
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Antioxidant Properties of Plumbagin |
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328 | (1) |
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Chemopreventive and Antitumor Properties of Plumbagin |
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328 | (7) |
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Antiangiogenic Property of Plumbagin |
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335 | (1) |
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Plumbagin Nano-Particle Preparations |
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336 | (1) |
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Anti-inflammatory Properties of Plumbagin |
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337 | |
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Chemosensitizing Properties of Plumbagin |
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331 | (7) |
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338 | (1) |
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338 | (5) |
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17 Role of Zerumbone in the Chemosensitization of Cancer Cells |
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343 | (8) |
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343 | (1) |
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343 | (2) |
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Source and Chemistry of Zerumbone |
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345 | (1) |
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Zerumbome Promotes the Chemosensitization of Paclitaxel and Cisplatin in Cancer Cells |
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345 | (1) |
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Zerumbone is a Dual Inhibitor of JAK/STAT3 and NF-κB Signaling |
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346 | (1) |
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Zerumbone-Mediated Chemosensitization In Vitro and In Vivo |
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347 | (1) |
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347 | (1) |
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348 | (3) |
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18 Multitalented Ginger and Its Clinical Development for Cancer Treatment |
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351 | (20) |
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351 | (1) |
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352 | (1) |
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Almighty Ginger to Treat Mighty Cancer |
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353 | (7) |
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Clinical Translation of Ginger: Major Roadblocks |
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360 | (1) |
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Innovative Modern Concepts to Further Clinical Translation of Ginger |
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361 | (3) |
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364 | (1) |
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365 | (1) |
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365 | (6) |
Index |
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371 | |