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E-raamat: Role of Nutraceuticals in Cancer Chemosensitization

Volume editor (Professor, Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Cam), Volume editor , Series edited by (Professor, Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, USA)
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Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy.

  • Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field
  • Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients
  • Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations
Contributors ix
About the Editors xi
About the Series Editor xiii
Aims and Scope for Series "Cancer Sensitizing Agents for Chemotherapy" xv
Preface xvii
1 Pathways Linked to Cancer Chemores istance and Their Targeting by Nutraceuticals
1(30)
Alok Chandra Bharti
Kanchan Vishnoi
Sukh Mahendra Singh
Bharat Bhushan Aggarwal
Abstract
1(1)
Introduction
2(1)
Chemotherapy
3(4)
Chemoresistance: Problem in Curing Cancer
7(1)
Mechanism of Chemoresistance
8(6)
Chemosensitization: An Approach to Target Cancer
14(1)
Nutraceuticals as Chemosensitizers: Opportunities and Challenges
14(5)
Conclusion
19(1)
Conflict of Interest
19(1)
Acknowledgments
19(1)
References
19(12)
2 The Potential of Curcumin: A Multitargeting Agent in Cancer Cell Chemosensitization
31(30)
Devtvasha Nordolol
Ajaikumar B. Kunnumakkara
Abstract
31(1)
Introduction
31(2)
Chemosensitization Studies of Curcumin in Different Cancers
33(18)
Conclusion
51(1)
Conflict of Interest
52(1)
Acknowledgment
52(1)
References
52(8)
Further Reading
60(1)
3 Role of Resveratrol in Chemosensitization of Cancer
61(16)
Sabira Mohammed
Kuzhuvelil B. Harikumar
Abstract
61(1)
Introduction
61(1)
Source and Chemistry of Resveratrol
62(1)
Possible Molecular Mechanisms of Chemoresistance in Cancer
62(3)
Chemosensitization Studies Using Resveratrol in Vitro
65(3)
Chemosensitization Studies Using Resveratrol in Vivo
68(2)
Human Clinical Trials Involving Resveratrol in Cancer
70(1)
Conclusion and Future Perspective
71(1)
References
71(5)
Further Reading
76(1)
4 Role of Tocotrienols in Chemosensitization of Cancer
77(22)
Kazim Husain
Mokenge P. Malafa
Abstract
77(1)
Introduction
77(1)
Source and Chemistry of Tocotrienols
78(1)
Molecular Targets of Tocotrienols in Cancer
79(2)
Mechanisms of Anticancer Action of Tocotrienols
81(2)
Chemosensitization by Tocotrienols
83(2)
Chemosensitization In Vitro
85(5)
Chemosensitization In Vivo
90(1)
Chemosensitization in Human
91(1)
Conclusion
91(1)
References
91(8)
5 Chemosensitization by Ursolic Acid: A New Avenue for Cancer Therapy
99(12)
Sahdeo Prasad
Amit K. Tyagi
Bharat Bhushan Aggarwal
Abstract
99(1)
Introduction
99(2)
Chemosensitization of Cancer Cells
101(5)
Safety and Efficacy
106(1)
Conclusion and Future Direction
106(1)
Acknowledgment
107(1)
References
107(4)
6 Role of Fisetin in Chemosensitization
111(30)
Bokyung Sung
Abstract
111(1)
Introduction
112(1)
Chemistry and Sources of Fisetin
113(2)
Molecular Targets of Fisetin
115(11)
Chemosensitization by Fisetin
126(7)
Conclusion
133(1)
Conflict of Interest
134(1)
References
134(7)
7 Role of Celastrol in Chemosensiti zation of Cancer
141(10)
Nur S. Amirruddin
Alan P. Kumar
Adrian K.K. Teo
Gautam Sethi
Abstract
141(1)
Introduction
141(1)
Biological Source of Celastrol and Its Chemistry
142(1)
Molecular Targets of Celastrol and Its Potential Mechanism(s) of Action
143(2)
Anticancer and Chemosensitizing Effects of Celastrol
145(3)
Conclusions
148(1)
Conflict of Interest
148(1)
Acknowledgments
148(1)
References
148(3)
8 Role of Gambogic Acid in Chemosensitization of Cancer
151(18)
Vijay P. Kale
Patrick J. Gilhooley
Sangita Phadtare
Ali Naba Vizadeh
Manoj K. Pandey
Abstract
151(1)
Introduction
151(4)
Source and Chemistry of GA
155(1)
Molecular Targets of GA
155(4)
Chemo-Sensitization by GA
159(2)
Conclusion
161(1)
References
161(8)
9 Role of Catechins in Chemosensitization
169(30)
Anand Swaroop Shukla
Abhimanyu Kumar Jha
Rani Kumari
Kavita Rawat
Saima Syeda
Anju Shrivastava
Abstract
169(2)
Introduction
171(1)
Sources of Catechins
172(1)
Structure and Chemistry of Catechins
173(4)
Molecular Targets of the Catechin
177(5)
Chemosensitization in Vitro
182(4)
Chemosensitization in Vivo
186(2)
Human Trials
188(1)
Implication of Catechins in Other Diseases
189(3)
Conclusion
192(1)
Conflict of Interest
193(1)
Acknowledgment
193(1)
References
193(5)
Further Reading
198(1)
10 Anticancer Attributes of Silibinin: Chemo- and Radiosensitization of Cancer
199(22)
Arpit Dheeraj
Dhanir Tailor
Surya P. Singh
Rana P. Singh
Abstract
199(1)
Introduction
200(2)
Structural Composition and Bioavailability of Silymarin/Silibinin
202(1)
Targeting of Various Attributes of Cancer Growth and Progression
203(7)
Silibinin as Chemosensitizer for Cancer Cells
210(3)
Silibinin as Radiosensitizer for Cancer Cells
213(1)
Conclusions
214(1)
References
215(6)
11 Berberine as an Adjuvant and Sensitizer to Current Chemotherapy
221(38)
Alok Chandra Bharti
Priyanka Rajan
Mohit Jadli
Deepti Pande
Tejveer Singh
Anjali Bhat
Abstract
221(1)
Introduction
222(1)
Source and Chemistry
222(1)
Evidence Showing the Potential of Berberine as a Chemosensitizer
223(9)
Hermetic Effects of Berberine in In Vitro Studies
232(1)
Chemosensitization In Vivo and Other Beneficial Properties
232(1)
Berberine in Human Trials
233(1)
Conclusion
234(1)
Conflict of Interest
235(1)
Acknowledgments
235(1)
References
235(6)
Role of Emodin in Chemosensitization of Cancer
241(1)
Subash Chandra Gupta, Vipin Rai
Abstract
241(2)
Introduction
243(1)
Anti-cancer Activities of Emodin
243(6)
Anti-cancer Activities of Emodin Analogues
249(1)
Chemosensitization of Tumors by Emodin
250(4)
Conclusions
254(1)
Acknowledgments
255(1)
References
255(4)
13 Role of Piperine in Chemoresistance
259(28)
Sandeep Kumar
Chetna Bhandari
Prerna Sharma
Navneet Agnihotri
Abstract
259(1)
Introduction
259(1)
Sources and Chemisrry of Piperine
260(1)
Piperine Extraction and Quantification
261(1)
Medicinal & Pharmacological Activities of Piperine
262(2)
Mechanism of Action of Piperine
264(6)
Chemoresistance and Chemosensitisation
270(5)
Interactions of Piperine With Chemotherapeutic Drugs
275(4)
Conclusion
279(1)
References
280(6)
Further Reading
286(1)
14 Role of Deguelin in Chemoresistance
287(10)
Sankar Jagadeeshan
M. Manu Prasad
Shivakumari Asha Nair
Abstract
287(1)
Introduction
287(1)
Source and Chemistry of Deguelin
288(1)
Molecular Targets of Deguelin
288(1)
Chemosensitization by Deguelin
288(4)
Conclusion
292(1)
Acknowledgements
293(1)
References
294(3)
15 Garcinol: Preclinical Perspective Underpinning Chemo- and Radiosensitization of Cancer
297(28)
Sanjeev Banerjee
Mansi A. Parasramka
Shivani R. Paruthy
Abstract
297(1)
Introduction
297(2)
Garcinol Bioavailability
299(1)
Garcinol: Therapeutic Targets
299(11)
Systemic Anticancer and Chemo-Sensitizing Effects of Garcinol
310(8)
Garcinol and TRAIL Sensitization
318(1)
Garcinol and Radiosensitization
319(1)
Garcinol Combination With Other Natural Agents' on Cancer Therapy
319(1)
Conclusion
320(1)
References
320(5)
16 Chemopreveritive and Anticancer Effects of Plumbagin: Novel Mechanism(s) via Modulation of Cellular Redox
325(18)
Rahul Checker
Raghavendra S. Patwardhan
Deepak Sharma
Santosh K. Sandur
Abstract
325(1)
Introduction
325(2)
Occurrence and Isolation of Plumbagin
327(1)
Antioxidant Properties of Plumbagin
328(1)
Chemopreventive and Antitumor Properties of Plumbagin
328(7)
Antiangiogenic Property of Plumbagin
335(1)
Plumbagin Nano-Particle Preparations
336(1)
Anti-inflammatory Properties of Plumbagin
337(1)
Chemosensitizing Properties of Plumbagin
337(1)
Conclusion
338(1)
References
338(5)
17 Role of Zerumbone in the Chemosensitization of Cancer Cells
343(8)
Arup Chakraborty
Abstract
343(1)
Introduction
343(2)
Source and Chemistry of Zerumbone
345(1)
Zerumbome Promotes the Chemosensitization of Paclitaxel and Cisplatin in Cancer Cells
345(1)
Zerumbone is a Dual Inhibitor of JAK/STAT3 and NF-kB Signaling
346(1)
Zerumbone-Mediated Chemosensitization In Vitro and In Vivo
347(1)
Conclusion
347(1)
References
348(3)
18 Multitalented Ginger and Its Clinical Development for Cancer Treatment
351(20)
Roopali Saxena
Ritu Aneja
Abstract
351(1)
Introduction
352(1)
Almighty Ginger to Treat Mighty Cancer
353(7)
Clinical Translation of Ginger: Major Roadblocks
360(1)
Innovative Modern Concepts to Further Clinical Translation of Ginger
361(3)
Conclusion
364(1)
Conflict of Interest
365(1)
References
365(6)
Index 371
Dr Bonavida has vast expertise and various reported publications in the field of tumor cell sensitization to chemotherapy (a total of greater than 500 publications) and in particular the novel role of Nitric Oxide (NO) donors in chemo-sensitization and reversal of drug resistance. In addition, he was the first scientist to co-organize an international meeting on the topic (First International Workshop on NO and Cancer, 2005).

Dr. Alok Chandra Bharti is Professor of Molecular Oncology at the Department of Zoology, Faculty of Science, University of Delhi, Delhi, India. Until December 31, 2015, Dr. Bharti was serving as a Head, Division of Molecular Oncology, Institute of Cytology and Preventive Oncology (renamed as National Institute of Cancer Prevention and Research), Indian Council of Medical Research, Noida. Dr. Bharti has made outstanding contributions in basic and applied research particularly in understanding molecular mechanisms of carcinogenesis and made efforts in developing nutraceutical-based novel anti-cancer, and anti-HPV therapeutics. His research on transcriptional (dys)regulation mediated by STAT-3, NF-kappaB and AP-1 during carcinogenesis indicated their role in cell survival and maintenance of stemness responsible for cancer chemoresistance. Dr. Bharti is also actively involved in development of cost-effective HPV diagnostics for cervical cancer. He was involved in the development of uniform international standards for HPV DNA diagnostics by WHO, Geneva. Dr. Bharti is an expert member of Institutional Technical Committee of Delhi State Cancer Institute (since 2011), Institutional BioSafety Committee of University of Delhi Ambedkar Centre for Biomedical Research (since 2011), and national faculty of DST-INSPIRE program for promotion of science in India (since 2010). He was awarded of INSA Medal for Young Scientist (2009) in Basic and Applied Medical Sciences Indian National Science Academy (INSA). Dr. Bharti has published over 100 research and review articles and book chapters in international peer reviewed journals and books. Dr. Bharti has co-edited a Special Issue of Indian Journal of Medical Research on Human Papillomavirus and Cervical Cancer” in September 2009. His research focuses on molecular oncology, anti-cancer nutraceuticals and their mechanism of action, tumor immunology, molecular diagnosis, molecular pharmacology, cancer stem cell biology, host virus interactions, transcriptional regulation Dr. Aggarwal is currently a Founding Director of the Inflammation Research Center in San Diego, California. He is also currently serving on the Advisory Board of several Nutraceutical companies. Until December 31st, 2015, Dr. Aggarwal was a Ransom Horne Distinguished Professor of Experimental Therapeutics, Cancer Research, Cancer Medicine, Biochemistry and Immunology; and Chief of the Cytokine Research Section, in the Department of Experimental Therapeutics at the University of Texas M. D. Anderson Cancer Center, Houston, Texas. He also served as a member of the University of Texas Graduate School of Biomedical Sciences, Houston, and as an Adjunct Professor at Albert B. Alkek Institute of Biosciences and Technology, Texas A&M University, Houston, Texas.