Muutke küpsiste eelistusi

Understanding Cancer [Pehme köide]

(University of Cambridge)
  • Formaat: Paperback / softback, 258 pages, kõrgus x laius x paksus: 178x127x14 mm, kaal: 310 g, Worked examples or Exercises
  • Sari: Understanding Life
  • Ilmumisaeg: 09-Jun-2022
  • Kirjastus: Cambridge University Press
  • ISBN-10: 1009005995
  • ISBN-13: 9781009005999
Teised raamatud teemal:
  • Formaat: Paperback / softback, 258 pages, kõrgus x laius x paksus: 178x127x14 mm, kaal: 310 g, Worked examples or Exercises
  • Sari: Understanding Life
  • Ilmumisaeg: 09-Jun-2022
  • Kirjastus: Cambridge University Press
  • ISBN-10: 1009005995
  • ISBN-13: 9781009005999
Teised raamatud teemal:
One in two of us will develop cancer at some point in our lives and yet many of us don't understand how cancers arise. How many different kinds of cancer are there? What treatments are available? What does the future hold in terms of developing new therapies? This book demystifies cancer by explaining the underlying cell and molecular biology in a clear and accessible style. It answers the questions commonly asked about cancer such as what causes cancer and how cancer develops. It explains how DNA makes proteins and how mutations can corrupt those proteins. It also gives an overview of current therapies and how treatments may advance over the next decades, as well as explaining what actions we can take to help prevent cancer developing. Understanding Cancer is an accessible and engaging introduction to cancer biology for any interested reader.

This book will enable general readers to understand the molecular features of cancer. It answers the questions commonly asked about cancer, looks at the global statistics, describes how damage to DNA (aka mutations) corrupts the behaviour of cells, explains current therapies and how treatments may advance in future.

Arvustused

'How often have we attended a lecture or opened a book to find that within minutes we are smothered by complicated facts that are way beyond our understanding? There has been no simple introduction. The speaker/author is so involved in the topic that they could no longer see out of the intellectual hole that they had dug for themselves. If ever a book was written to dispel this fault, then this is the one, as Robin Hesketh has managed to provide a remarkably clear and readable account of the science behind cellular behaviour and faults that lead to the development of cancer. The book reads like a novel, and I found that I could hardly put it down. The literary style is at times light-hearted with humorous analogies.' Robert Whitaker, anatomist, University of Cambridge 'Understanding Cancer presents a carefully crafted, clear and concise book on aspects of cancer; a disease of importance to us all. Most readers will come to Robin Hesketh's book with questions about cancer. Understanding Cancer will not disappoint. The most usual questions and answers are presented in the first chapter and ways of reducing the risk of some cancers are suggested later. This book puts cancer into a historical and very interesting context; it then explores cancer, its biochemistry and functioning in an approachable way. Information is given about the latest treatments and the science behind them. This very readable book contains something for everyone. It is positioned, and very adequately fills, the gap between personal accounts by patients of their experiences, and more advanced medical and cell biology texts. Understanding Cancer is well researched and greatly recommended.' David Archer, schools liaison officer, British Society for Cell Biology 'Understanding Cancer is a fascinating and engaging perspective on the evolution of cancer research and treatment. Dr Hesketh provides insight into the key clinicians and scientists, following their discoveries in clinical care and research. He overviews the likely mutagenic causes of cancer spurring on the oncogenic transitions leading to a cancer cell that can replicate uncontrollably, highlights new avenues in cancer research, and conveys that preventive measures and advances in early cancer detection could make an impact on cancer incidence and patient outcomes/survival. This book is certainly a triumph and a must-read for all current and future scientists, physicians at any stage of their professional careers and anyone interested in cancer research and the quest for effective anti-cancer treatments.' David Lyden, David Lyden, cancer researcher and paediatric oncologist, Weill Cornell Medicine, Cornell University ' this is an enjoyable and compelling read and includes a list of references appropriate for each chapter and a helpful index Highly recommended.' J. M. Miller, Choice

Muu info

Explains, in simple terms, the molecular events that drive cancers, current therapies and potential future treatments.
Foreword xvii
Preface xix
Acknowledgements xxi
Gene Names xxiii
1 Painting a Clear Picture
1(18)
What is Cancer?
2(1)
What Causes Cancer?
3(3)
Are All Cancers Equally Bad?
6(1)
Malignant versus Benign
6(2)
Warts and All
8(1)
Why Do Some Children Get Cancer?
9(1)
How Many Different Cancers Are There?
10(1)
Is There A Difference Between Men and Women?
11(1)
Can You Catch Cancer from Someone Else?
11(1)
Do Metastases Metastasize?
12(1)
How Does Cancer Kill?
13(1)
Can Plants Get Cancer?
13(1)
Can We Cure Cancer?
14(1)
Can Cancer be Modelled?
14(2)
Admiring the Picture
16(3)
2 Ancient History
19(16)
The Greeks Had a Word for It
20(2)
Chinese Science
22(1)
The Coming of Science
23(1)
Scientific Observation and the Practice of Medicine
24(2)
The Advance of Surgery
26(3)
The Coming of Cell Biology
29(6)
3 Counting Cancer
35(13)
The Big Picture
35(1)
The Global Picture
36(3)
The UK
39(1)
What's the Cause?
40(1)
The USA
41(1)
Counting the Cost of Cancer
42(3)
Have We Made Any Progress?
45(2)
Not a Pretty Picture
47(1)
4 From DNA to Protein
48(16)
Atoms and Molecules
49(1)
Our Genetic Material
49(1)
The Double Helix
50(2)
Deciphering the Code
52(1)
The Central Dogma
53(1)
Coding Power
54(1)
Shape Is All
55(1)
Controlling RNA Expression
55(1)
The Road to Sequencing DNA
56(1)
Genetic Maps
57(1)
Assembling the Toolkit
58(2)
The Sequencing of DNA
60(4)
5 What Is a Cell?
64(12)
Talking to Cells
66(3)
Steroid Hormones
69(1)
Je Pense, Done Je Suis un Blancmange
70(1)
Perturbing Cellular Balance
70(1)
The Cycle That Makes Two Cells from One
71(1)
Major Kinase Targets in the Cell Cycle Clock
72(4)
6 Mutations
76(27)
The First Experiment
78(2)
The Age of Oncogenes
80(1)
The First Human Oncogene
80(1)
Making Mutant Proteins
81(1)
A Single Base Change: Minimal Mutations in Molecular
Switches - RAS
82(2)
Missing Bits: Deaf to the World - EGFR
84(2)
Patching Proteins: Chromosome Translocations Make Novel Proteins
86(1)
Revelations from Leukaemia
86(2)
Replacing the Controller
88(1)
Multiplying Genes
88(2)
Genes Go Missing: RB1
90(2)
Tumour Protein 53
92(1)
The Double Life of p53
93(1)
Exploding DNA
93(2)
Micro RNAs
95(1)
Genetic Variations
96(1)
Viruses
97(1)
DNA Viruses
97(1)
RNA Viruses
98(1)
The Pan-Cancer Project
98(1)
Playing Games
99(2)
The Genomic Cancer Message
101(2)
7 Causes of Cancer That Can be Controlled
103(31)
And Another Thing
103(2)
Controversial or What... ?
105(1)
Alcohol and Cancer
105(2)
Diet
107(11)
Obesity
118(10)
Tea (and Coffee)
128(1)
Tobacco
129(5)
8 Causes of Cancer That Are Difficult to Control, Accidents and Other Things
134(13)
Infection
134(1)
Radiation
135(2)
Abnormal Exposures
137(4)
Ultraviolet Radiation
141(1)
Low-Frequency Magnetic Fields
142(1)
High-Frequency Magnetic Fields: Mobile Phones
143(1)
Radon
144(1)
Stress
144(1)
Where Do We Stand and What Can We Do?
145(2)
9 Treating Cancer by Chemotherapy
147(27)
Sound Familiar?
148(1)
Screening
148(1)
Mammography
149(2)
Diagnosis, Staging, Grading and Monitoring
151(1)
Imaging
151(3)
Chemotherapy for Cancer
154(1)
A New Era
155(1)
Inhibiting Proliferation
156(2)
Selective Oestrogen Receptor Modulators
158(2)
Oncoproteins: Growth Factors, Receptors, Signal Pathways
160(1)
Kinase Inhibitors
161(2)
Metabolism
163(1)
Apoptosis
164(1)
Angiogenesis
165(1)
Metastasis
166(2)
Controlling Metastatic Take-Off
168(1)
Breaking the Barrier
168(1)
Shooting the Messenger
169(1)
Infection by Oncogenic Viruses
170(1)
Therapeutic Vaccines
171(1)
Tumour Agnostic Drugs
171(1)
The Tumour Microenvironment
172(1)
A Serious Case of Corruption
172(2)
10 The Road to Utopia?
174(26)
Cancer Therapy: Immunotherapy
174(1)
Checkpoint Inhibitors
175(2)
Gene Therapy
177(1)
What Is CRISPR-Cas9?
178(3)
Liquid Biopsy
181(1)
Breath Biopsy
182(1)
Sponge on a String
182(2)
Epigenetics
184(1)
The Dutch Famine
185(1)
Finding Cancer by Epigenetics
185(1)
Epigenetic Drugs
186(1)
Nano-oncology
187(1)
Roboclot
187(3)
3D Tumour Printing
190(1)
Targeted Alpha-Particle Therapy
190(1)
Synthetic Lethality
190(2)
Personal versus Impersonal Medicine
192(1)
The Next Genomic Era
193(2)
Cancer Mosaics
195(1)
Breast Cancer Mutational Signatures
196(1)
The Breast Tumour Microenvironment
197(1)
Contemplating the Portrait
197(3)
Concluding Remarks
200(15)
Summary of Common Misunderstandings
202(2)
References
204(11)
Figure Credits 215(2)
Index 217
Robin Hesketh has been a member of the Department of Biochemistry at the University of Cambridge and a fellow of Selwyn College for over 40 years, working on cancer biology. He has published over 100 research papers, a textbook on cancer (Introduction to Cancer Biology, Cambridge, 2013) and popular science books (Betrayed by Nature, Palgrave, 2012). He has spoken on cancer and has run a blog on the topic of cancer for the general public since 2011.