| Foreword |
|
xvii | |
| Preface |
|
xix | |
| Acknowledgements |
|
xxi | |
| Gene Names |
|
xxiii | |
|
1 Painting a Clear Picture |
|
|
1 | (18) |
|
|
|
2 | (1) |
|
|
|
3 | (3) |
|
Are All Cancers Equally Bad? |
|
|
6 | (1) |
|
|
|
6 | (2) |
|
|
|
8 | (1) |
|
Why Do Some Children Get Cancer? |
|
|
9 | (1) |
|
How Many Different Cancers Are There? |
|
|
10 | (1) |
|
Is There A Difference Between Men and Women? |
|
|
11 | (1) |
|
Can You Catch Cancer from Someone Else? |
|
|
11 | (1) |
|
Do Metastases Metastasize? |
|
|
12 | (1) |
|
|
|
13 | (1) |
|
|
|
13 | (1) |
|
|
|
14 | (1) |
|
|
|
14 | (2) |
|
|
|
16 | (3) |
|
|
|
19 | (16) |
|
The Greeks Had a Word for It |
|
|
20 | (2) |
|
|
|
22 | (1) |
|
|
|
23 | (1) |
|
Scientific Observation and the Practice of Medicine |
|
|
24 | (2) |
|
|
|
26 | (3) |
|
The Coming of Cell Biology |
|
|
29 | (6) |
|
|
|
35 | (13) |
|
|
|
35 | (1) |
|
|
|
36 | (3) |
|
|
|
39 | (1) |
|
|
|
40 | (1) |
|
|
|
41 | (1) |
|
Counting the Cost of Cancer |
|
|
42 | (3) |
|
Have We Made Any Progress? |
|
|
45 | (2) |
|
|
|
47 | (1) |
|
|
|
48 | (16) |
|
|
|
49 | (1) |
|
|
|
49 | (1) |
|
|
|
50 | (2) |
|
|
|
52 | (1) |
|
|
|
53 | (1) |
|
|
|
54 | (1) |
|
|
|
55 | (1) |
|
Controlling RNA Expression |
|
|
55 | (1) |
|
The Road to Sequencing DNA |
|
|
56 | (1) |
|
|
|
57 | (1) |
|
|
|
58 | (2) |
|
|
|
60 | (4) |
|
|
|
64 | (12) |
|
|
|
66 | (3) |
|
|
|
69 | (1) |
|
Je Pense, Done Je Suis un Blancmange |
|
|
70 | (1) |
|
Perturbing Cellular Balance |
|
|
70 | (1) |
|
The Cycle That Makes Two Cells from One |
|
|
71 | (1) |
|
Major Kinase Targets in the Cell Cycle Clock |
|
|
72 | (4) |
|
|
|
76 | (27) |
|
|
|
78 | (2) |
|
|
|
80 | (1) |
|
|
|
80 | (1) |
|
|
|
81 | (1) |
|
A Single Base Change: Minimal Mutations in Molecular Switches - RAS |
|
|
82 | (2) |
|
Missing Bits: Deaf to the World - EGFR |
|
|
84 | (2) |
|
Patching Proteins: Chromosome Translocations Make Novel Proteins |
|
|
86 | (1) |
|
Revelations from Leukaemia |
|
|
86 | (2) |
|
|
|
88 | (1) |
|
|
|
88 | (2) |
|
|
|
90 | (2) |
|
|
|
92 | (1) |
|
|
|
93 | (1) |
|
|
|
93 | (2) |
|
|
|
95 | (1) |
|
|
|
96 | (1) |
|
|
|
97 | (1) |
|
|
|
97 | (1) |
|
|
|
98 | (1) |
|
|
|
98 | (1) |
|
|
|
99 | (2) |
|
The Genomic Cancer Message |
|
|
101 | (2) |
|
7 Causes of Cancer That Can be Controlled |
|
|
103 | (31) |
|
|
|
103 | (2) |
|
Controversial or What...? |
|
|
105 | (1) |
|
|
|
105 | (2) |
|
|
|
107 | (11) |
|
|
|
118 | (10) |
|
|
|
128 | (1) |
|
|
|
129 | (5) |
|
8 Causes of Cancer That Are Difficult to Control, Accidents and Other Things |
|
|
134 | (13) |
|
|
|
134 | (1) |
|
|
|
135 | (2) |
|
|
|
137 | (4) |
|
|
|
141 | (1) |
|
Low-Frequency Magnetic Fields |
|
|
142 | (1) |
|
High-Frequency Magnetic Fields: Mobile Phones |
|
|
143 | (1) |
|
|
|
144 | (1) |
|
|
|
144 | (1) |
|
Where Do We Stand and What Can We Do? |
|
|
145 | (2) |
|
9 Treating Cancer by Chemotherapy |
|
|
147 | (27) |
|
|
|
148 | (1) |
|
|
|
148 | (1) |
|
|
|
149 | (2) |
|
Diagnosis, Staging, Grading and Monitoring |
|
|
151 | (1) |
|
|
|
151 | (3) |
|
|
|
154 | (1) |
|
|
|
155 | (1) |
|
|
|
156 | (2) |
|
Selective Oestrogen Receptor Modulators |
|
|
158 | (2) |
|
Oncoproteins: Growth Factors, Receptors, Signal Pathways |
|
|
160 | (1) |
|
|
|
161 | (2) |
|
|
|
163 | (1) |
|
|
|
164 | (1) |
|
|
|
165 | (1) |
|
|
|
166 | (2) |
|
Controlling Metastatic Take-Off |
|
|
168 | (1) |
|
|
|
168 | (1) |
|
|
|
169 | (1) |
|
Infection by Oncogenic Viruses |
|
|
170 | (1) |
|
|
|
171 | (1) |
|
|
|
171 | (1) |
|
The Tumour Microenvironment |
|
|
172 | (1) |
|
A Serious Case of Corruption |
|
|
172 | (2) |
|
|
|
174 | (30) |
|
Cancer Therapy: Immunotherapy |
|
|
174 | (1) |
|
|
|
175 | (2) |
|
|
|
177 | (1) |
|
|
|
178 | (3) |
|
|
|
181 | (1) |
|
|
|
182 | (1) |
|
|
|
182 | (2) |
|
|
|
184 | (1) |
|
|
|
185 | (1) |
|
Finding Cancer by Epigenetics |
|
|
185 | (1) |
|
|
|
186 | (1) |
|
|
|
187 | (1) |
|
|
|
187 | (3) |
|
|
|
190 | (1) |
|
Targeted Alpha-Particle Therapy |
|
|
190 | (1) |
|
|
|
190 | (2) |
|
Personal versus Impersonal Medicine |
|
|
192 | (1) |
|
|
|
193 | (2) |
|
|
|
195 | (1) |
|
Breast Cancer Mutational Signatures |
|
|
196 | (1) |
|
The Breast Tumour Microenvironment |
|
|
197 | (1) |
|
Contemplating the Portrait |
|
|
197 | (3) |
|
|
|
200 | (2) |
|
Summary of Common Misunderstandings |
|
|
202 | (2) |
| References |
|
204 | (11) |
| Figure Credits |
|
215 | (2) |
| Index |
|
217 | |