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Attention, Genes and ADHD [Kõva köide]

Edited by , Edited by (University of Auckland, NZ)
  • Formaat: Hardback, 288 pages, kõrgus x laius: 234x156 mm, kaal: 600 g
  • Ilmumisaeg: 14-Jun-2001
  • Kirjastus: Psychology Press Ltd
  • ISBN-10: 1841691933
  • ISBN-13: 9781841691930
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  • Formaat: Hardback, 288 pages, kõrgus x laius: 234x156 mm, kaal: 600 g
  • Ilmumisaeg: 14-Jun-2001
  • Kirjastus: Psychology Press Ltd
  • ISBN-10: 1841691933
  • ISBN-13: 9781841691930
Presents research currently underway concerning Attention Deficit Hyperactivity Disorder (ADHD) and related conditions. Reviews and integrate both behavior genetic and molecular genetic advances in the field. The volume's 13 contributions, written primarily by North American and a few Australian researchers, include coverage of modern techniques, current findings, implications for education and intervention, and the future role of genetic studies of ADHD. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Recent advances in genetic methodology are providing important aetiological and developmental information to the growing literature on Attention Deficit Hyperactivity Disorder (ADHD) and related conditions. Attention, Genes and ADHD is the first book to review and integrate both behaviour-genetic and molecular-genetic advances in this area. It brings together international researchers to show how modern techniques may be applied to the investigation of ADHD, and reviews current findings in the field of ADHD and related conditions.
The book looks at the application of behaviour genetic approaches to twin studies, and reviews diagnostic to ADHD, the relationships between reading, spelling and ADHD, and family and genetic influences on speech and speech and language.
Chapters go on to consider the overlaps between ADHD, Oppositional Defiant Disorder and Conduct Disorder and to explore the environmental and genetic influences among these disorders. The neurobiological and genetic relationship between ADHD and Tourette's Disorder is also examined. The book reviews recent advances in molecular genetics - in particular a discussion of Fragile X as a model for a single single gene effects on ADHD, and the application of genetic methods and approaches to the study of candidate genes. Finally, the implications for education and intervention are discussed, and current and future roles of gentic studies of ADHD are explored, as well as implications of the sequencing of the human genome for child psychiatry.
List of contributors xi Preface xiii Acknowledgements xv Introduction 1(6) Florence Levy Introduction to the genetic analysis of attentional disorders 7(28) David A. Hay Michael McStephen Florence Levy The aims of behaviour genetics 7(2) Why are people different? 9(1) The tools of behaviour genetics 10(4) An example of genetic analysis of ADHD 14(11) Is ADHD a continuum or a discrete category? 25(5) Discussion 30(2) References 32(3) The diagnostic genetics of ADHD symptoms and subtypes 35(23) Florence Levy Michael McStephen David A. Hay Introduction 35(1) Diagnostic genetics 36(1) Categorical versus dimensional systems 37(1) Heritability 38(1) Australian Twin ADHD Project (ATAP) 38(1) Concordance data 39(3) Genetic analysis 42(3) Item analysis 45(1) Univariate item analysis 46(3) Multivariate item analysis 49(3) Discussion 52(3) References 55(3) The developmental genetics of ADHD 58(22) David A. Hay Michael McStephen Florence Levy Introduction 58(4) Stability and changes in symptomatology 62(6) The long-term outcome of ADHD 68(3) Psychopathology in adult relatives of young people with ADHD 71(1) Trends in molecular studies 72(1) Discussion 73(3) References 76(4) Familial and genetic bases of speech and language disorders 80(19) Barbara A. Lewis The search for phenotype definitions 81(1) Studies of phenotypes 82(2) Incidencelprevalence 84(1) Gender as a risk factor 84(1) Familial aggregation 85(1) Studies that suggest a genetic component/genetic studies 85(2) Comorbid disorders 87(3) Pilot data 90(2) Genetic explanations 92(2) Summary 94(1) References 94(5) Comorbidity of reading/spelling disability and ADHD 99(16) Jim Stevenson Defining reading and spelling disabilities 99(2) Epidemiological evidence for the high comorbidity of ADHD and RSD 101(3) Quantitative genetic studies of RSD 104(3) Molecular genetic studies of RSD 107(1) Evidence for shared genetic influences on ADHD and RSD 108(2) Conclusions 110(1) References 110(5) Causes of the overlap among symptoms of ADHD, Oppositional Defiant Disorder, and Conduct Disorder 115(24) Irwin D. Waldman Soo Hyun Rhee Florence Levy David A. Hay Method 119(5) Results 124(9) Discussion 133(3) References 136(3) Aetiology of the sex difference in the prevalence of DSM-III-R ADHD: a comparison of two models 139(18) Soo Hyun Rhee Irwin D. Waldman David A. Hay Florence Levy Differences between ADHD boys and girls 139(2) Sex differences in the prevalence of ADHD 141(4) Present study 145(6) Results 151(1) Discussion 152(2) References 154(3) Single gene studies of ADHD 157(16) Alan Zametkin Monique Ernst Robert Cohen Introduction 157(1) Genetics 157(1) Molecular studies 158(3) Recent studies investigating single genes 161(1) Gene to brain 162(1) Fragile-X syndrome 163(4) References 167(6) Molecular genetics of ADHD 173(23) Cathy Barr James Swanson James Kennedy Introduction 173(3) Characterisation of the ADHD phenotype for genetic studies 176(5) Design of studies for molecular genetics 181(1) Molecular genetics 182(2) Genetic data analyses 184(2) Molecular genetic studies of ADHD 186(2) Summary and future directions 188(1) References 189(7) The genetic relationship between ADHD and Gilles de la Tourette syndrome 196(18) David Pauls Nancy Fredine Kimberly Lynch Charles R. Hurst John P. Alsobrook II Phenomenology and natural history of ADHD 197(1) Neuropsychological assessment of GTS and ADHD 198(10) Molecular genetic studies of GTS and ADHD 208(1) Summary 208(1) References 209(5) Implications of genetic studies of attention problems for education and intervention 214(11) David A. Hay Florence Levy Diagnosis 215(1) Comorbidity 216(1) Intervention 216(1) Family dynamics 217(1) Language and ADHD 217(1) Comorbidity and schooling 218(1) Implications of molecular genetics 219(2) Ethical issues 221(1) Agenda for psychiatric genetics 221(1) Conclusion 222(1) References 223(2) Child psychiatry in the era following sequencing the genome 225(24) Michael Rutter Introduction 225(1) Clinical concepts 226(3) Genetic risk mechanisms 229(3) Searching for susceptibility genes 232(3) Finding out what genes do 235(2) Clinical benefits of genetic research 237(2) Diagnosis 239(3) Conclusion 242(1) References 242(7) Author index 249(14) Subject index 263
Florence Levy (Edited by) ,  David Hay (Edited by)