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E-raamat: Attention, Genes and ADHD

Edited by (University of Auckland, NZ), Edited by
  • Formaat: EPUB+DRM
  • Ilmumisaeg: 14-Apr-2021
  • Kirjastus: Psychology Press Ltd
  • Keel: eng
  • ISBN-13: 9781317710059
  • Formaat - EPUB+DRM
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  • Formaat: EPUB+DRM
  • Ilmumisaeg: 14-Apr-2021
  • Kirjastus: Psychology Press Ltd
  • Keel: eng
  • ISBN-13: 9781317710059

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Recent advances in genetic methodology are providing important aetiological and developmental information to the growing literature on Attention Deficit Hyperactivity Disorder (ADHD) and related conditions. Attention, Genes and ADHD is the first book to review and integrate both behaviour-genetic and molecular-genetic advances in this area. It brings together international researchers to show how modern techniques may be applied to the investigation of ADHD, and reviews current findings in the field of ADHD and related conditions.
The book looks at the application of behaviour genetic approaches to twin studies, and reviews diagnostic to ADHD, the relationships between reading, spelling and ADHD, and family and genetic influences on speech and speech and language.
Chapters go on to consider the overlaps between ADHD, Oppositional Defiant Disorder and Conduct Disorder and to explore the environmental and genetic influences among these disorders. The neurobiological and genetic relationship between ADHD and Tourette's Disorder is also examined. The book reviews recent advances in molecular genetics - in particular a discussion of Fragile X as a model for a single single gene effects on ADHD, and the application of genetic methods and approaches to the study of candidate genes. Finally, the implications for education and intervention are discussed, and current and future roles of gentic studies of ADHD are explored, as well as implications of the sequencing of the human genome for child psychiatry.
List of contributors
xi
Preface xiii
Acknowledgements xv
Introduction
1(6)
Florence Levy
Introduction to the genetic analysis of attentional disorders
7(28)
David A. Hay
Michael McStephen
Florence Levy
The aims of behaviour genetics
7(2)
Why are people different?
9(1)
The tools of behaviour genetics
10(4)
An example of genetic analysis of ADHD
14(11)
Is ADHD a continuum or a discrete category?
25(5)
Discussion
30(2)
References
32(3)
The diagnostic genetics of ADHD symptoms and subtypes
35(23)
Florence Levy
Michael McStephen
David A. Hay
Introduction
35(1)
Diagnostic genetics
36(1)
Categorical versus dimensional systems
37(1)
Heritability
38(1)
Australian Twin ADHD Project (ATAP)
38(1)
Concordance data
39(3)
Genetic analysis
42(3)
Item analysis
45(1)
Univariate item analysis
46(3)
Multivariate item analysis
49(3)
Discussion
52(3)
References
55(3)
The developmental genetics of ADHD
58(22)
David A. Hay
Michael McStephen
Florence Levy
Introduction
58(4)
Stability and changes in symptomatology
62(6)
The long-term outcome of ADHD
68(3)
Psychopathology in adult relatives of young people with ADHD
71(1)
Trends in molecular studies
72(1)
Discussion
73(3)
References
76(4)
Familial and genetic bases of speech and language disorders
80(19)
Barbara A. Lewis
The search for phenotype definitions
81(1)
Studies of phenotypes
82(2)
Incidence/prevalence
84(1)
Gender as a risk factor
84(1)
Familial aggregation
85(1)
Studi that suggest a genetic component/genetic studies
85(2)
Comorbid disorders
87(3)
Pilot data
90(2)
Genetic explanations
92(2)
Summary
94(1)
References
94(5)
Comorbidity of reading/spelling disability and ADHD
99(16)
Jim Stevenson
Defining reading and spelling disabilities
99(2)
Epidemiological evidence for the high comorbidity of ADHD and RSD
101(3)
Quantitative genetic studies of RSD
104(3)
Molecular genetic studies of RSD
107(1)
Evidence for shared genetic influences on ADHD and RSD
108(2)
Conclusions
110(1)
References
110(5)
Causes of the overlap among symptoms of ADHD, Oppositional Defiant Disorder, and Conduct Disorder
115(24)
Irwin D. Waldman
Soo Hyun Rhee
Florence Levy
David A. Hay
Method
119(5)
Results
124(9)
Discussion
133(3)
References
136(3)
Aetiology of the sex difference in the prevalence of DSM-III-R ADHD: a comparison of two models
139(18)
Soo Hyun Rhee
Irwin D. Waldman
David A. Hay
Florence Levy
Differences between ADHD boys and girls
139(2)
Sex differences in the prevalence of ADHD
141(4)
Present study
145(6)
Results
151(1)
Discussion
152(2)
References
154(3)
Single gene studies of ADHD
157(16)
Alan Zametkin
Monique Ernst
Robert Cohen
Introduction
157(1)
Genetics
157(1)
Molecular studies
158(3)
Recent studies investigating single genes
161(1)
Gene to brain
162(1)
Fragile-X syndrome
163(4)
References
167(6)
Molecular genetics of ADHD
173(23)
Cathy Barr
James Swanson
James Kennedy
Introduction
173(3)
Characterisation of the ADHD phenotype for genetic studies
176(5)
Design of studies for molecular genetics
181(1)
Molecular genetics
182(2)
Genetic data analyses
184(2)
Molecular genetic studies of ADHD
186(2)
Summary and future directions
188(1)
References
189(7)
The genetic relationship between ADHD and Gilles de la Tourette syndrome
196(18)
David Pauls
Nancy Fredine
Kimberly Lynch
Charles R. Hurst
John P. Alsobrook II
Phenomenology and natural history of ADHD
197(1)
Neuropsychological assessment of GTS and ADHD
198(10)
Molecular genetic studies of GTS and ADHD
208(1)
Summary
208(1)
References
209(5)
Implications of genetic studies of attention problems for education and intervention
214(11)
David A. Hay
Florence Levy
Diagnosis
215(1)
Comorbidity
216(1)
Intervention
216(1)
Family dynamics
217(1)
Language and ADHD
217(1)
Comorbidity and schooling
218(1)
Implications of molecular genetics
219(2)
Ethical issues
221(1)
Agenda for psychiatric genetics
221(1)
Conclusion
222(1)
References
223(2)
Child psychiatry in the era following sequencing the genome
225(24)
Michael Rutter
Introduction
225(1)
Clinical concepts
226(3)
Genetic risk mechanisms
229(3)
Searching for susceptibility genes
232(3)
Finding out what genes do
235(2)
Clinical benefits of genetic research
237(2)
Diagnosis
239(3)
Conclusion
242(1)
References
242(7)
Author index 249(14)
Subject index 263


Florence Levy (Edited by) ,  David Hay (Edited by)