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Nuts and Seeds in Health and Disease Prevention 2nd edition [Pehme köide]

Edited by (Professor, Mel and Eni), Edited by (Professor, Department of Clinical Biochemistry, Kings College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, Kings College London, UK Visiting Professor, University of Hull, UK)
  • Formaat: Paperback / softback, 598 pages, kõrgus x laius: 235x191 mm, kaal: 1200 g
  • Ilmumisaeg: 24-Apr-2020
  • Kirjastus: Academic Press Inc
  • ISBN-10: 0128185538
  • ISBN-13: 9780128185537
Teised raamatud teemal:
  • Formaat: Paperback / softback, 598 pages, kõrgus x laius: 235x191 mm, kaal: 1200 g
  • Ilmumisaeg: 24-Apr-2020
  • Kirjastus: Academic Press Inc
  • ISBN-10: 0128185538
  • ISBN-13: 9780128185537
Teised raamatud teemal:

Nuts and Seeds in Health and Disease Prevention, Second Edition investigates the benefits of nuts and seeds in health and disease prevention using an organizational style that will provide easy-access to information that supports identifying treatment options and the development of symptom-specific functional foods. This book examines seeds and nuts as agents that affect metabolism and other health-related conditions and explores the impact of compositional differences between various seeds and nuts, including differences based on country of origin and processing technique. Finally, the book includes methods for the analysis of seed and nut-related compounds.

Written for nutrition researchers, nutritionists, food scientists, government regulators of food, and students of agriculture, oils and feeds, nutrition and life sciences, this book is sure to be a welcomed resource.

  • Identifies options and opportunities for improving health through the consumption of nut and seed products
  • Provides easy access to information that supports the identification of treatment options
  • Contains insights into health benefits that will assist in development of symptom-specific functional foods
  • Examines seeds and nuts as agents that affect metabolism and other health-related conditions
  • Explores the impact of compositional differences between various seeds and nuts, including differences based on country of origin and processing technique
  • Includes methods for analysis of seed and nut-related compound
Contributors xiii
Preface xvii
Acknowledgments xix
I Overview and General Themes
1 Rambutan (Nephelium lappaceum L.) Seed and Its Fat
Julio A. Solis-Fuentes
Frixia Galan-Mendez
Maria del Rosario Hernandez-Medel
Man'a del Cannen Duran-de-Bazua
List of Abbreviations
3(1)
Introduction
4(1)
Botanical Descriptions
4(1)
Historical Cultivation and Usage
4(1)
Present-Day Cultivation and Usage
5(1)
Applications in Health Promotion and Disease Prevention
5(2)
Nephelium lappaceum Seed Fat (RSF) Characteristics, Potential Food, and Therapeutic Uses
7(3)
RSF and Its Potential Food Uses for Health Promotion
10(1)
Adverse Effects and Reactions, Allergies, and Toxicity
11(1)
Summary Points
11(1)
References
12(3)
2 Soursop Seed: Soursop (Armaria muricata L.) Seed, Therapeutic, and Possible Food Potential
Julio A. Solis-Fuentes
Maria del Rosario Hernandez-Medel
Maria del Carmen Duran-de-Bazua
List of Abbreviations
15(1)
Introduction
15(1)
Botanical Descriptions
16(1)
Historical Cultivation and Usage
16(1)
Present-day Cultivation and Usage
16(1)
Applications in Health Promotion and Disease Prevention
17(3)
Annona muricata Seed and Its Possible Potential for Food Use
20(3)
Adverse Effects and Reactions, Allergies, and Toxicity
23(1)
Summary Points
23(1)
References
24(3)
3 Red Horse-Chestnut Seeds of Aescuhis X Cornea: A New Way for Health and Food Design?
Cecilia Baraldi
Giorgia Foca
Laura Maletti
Andrea Marcherti
Fabrizio Roncaglia
Simona Sighinolfi
Lorenzo Tassi
List of Abbreviations
27(1)
Introduction
27(2)
Botanical Descriptions
29(1)
Historical Cultivation and Usage
29(2)
Red Horse-Chestnuts: Chemical Composition and Characterization
31(7)
Applications to Health Promotion and Disease Prevention
38(3)
Adverse Effects and Reactions (Allergies and Toxicity)
41(1)
Summary Points
41(1)
Acknowledgments
42(1)
References
42(3)
4 The African Breadfruit (Treculia africana) Decne Plant Seed: A Potential Source of Essential Food and Medicinal Phytoconstituents
Folake Lucy Oyetayo
Victor Olusegun Oyetayo
Introduction
45(1)
Botanical Description, Cultivation, and Usage
45(1)
Fruit Processing and Seed Production
46(1)
Nutritional Value and Food Uses of Treculia africanc Seed
47(1)
Antinutritional Compositions of African Breadfruit Seed
47(1)
Applications to Health Promotion and Disease Prevention
48(1)
Future Perspectives
49(1)
Acknowledgments
49(1)
References
49(2)
5 Perennial Horse Gram (Macrotyloma axillare) Seeds: Biotechnology Application: of Its Peptide and Protein Content --- Bowman---Birk Inhibitors and Lectin
Marcos Aurelio de Santana
William de Castro Borges
Alessandra de Paula Carli
Larissa Lovatto Amorin
Alexandre Goncalves Santos
Sonaly Cristine Leal
Milton Hercules Guerra de Andrade
List of Abbreviations
51(1)
Introduction
52(1)
Botanical Description
52(2)
Historical Cultivation and Usage
54(1)
Present-Day Cultivation and Usage
54(1)
Applications to Health Promotion and Disease Prevention --- Biotechnology Applications of the Protein Seed Content
55(7)
Adverse Effects and Reactions --- Toxicity of Macrotyloma axillare
62(1)
Summary Points
63(1)
References
63(4)
6 Biological Properties of a Partially Purified Component of Neem Oil: An Updated and Revised Work
Gianfranco Risulco
Introduction
67(3)
References
70(3)
7 Bioactive Compounds of Oregano Seed
Havva Atar
Hatice Colgecen
List of Abbreviation
73(1)
Introduction
73(1)
Botanical Description
74(1)
Historical Cultivation and Use
74(1)
Current Cultivation and Use
74(1)
Applications for Health Promotion and Disease Prevention
75(1)
Adverse Effects and Reactions, Allergies, and Toxicity
75(1)
Summary Points
76(1)
References
76(3)
8 Mango Seed: Mango (Mangifera indica L.) Seed and Its Fats
Julio A. Solis-Fuentes
Maria del Carmen Duran-de-Bazua
List of Abbreviations
79(1)
Introduction
79(1)
Botanical Description
80(1)
Historical Cultivation and Usage
80(1)
Present-Day Cultivation and Usage
80(1)
Applications to Health Promotion and Disease Prevention
81(7)
Adverse Effects and Reactions, Allergies, and Toxicity
88(1)
Summary Points
88(1)
References
88(5)
II Role of Seeds in Nutrition and Antioxidant Activities
9 Biological Functions of Soyasaponins: The Potential Use to Improve Zinc Nutrition
Taiho Kambe
Masakazu Takahashi
List of Abbreviations
93(1)
Introduction
93(1)
Zinc Nutrition and Health
94(1)
Zinc Absorption in the Small Intestine and Zinc Transporter, ZIP4
94(2)
Soybean Soyasaponin Bb Increases Z1P4 Abundance at the Apical Membrane
96(3)
Conclusion
99(1)
Acknowledgment
99(1)
References
100(3)
10 Purple Wheat (Triticum sp.) Seeds: Phenolic Composition and Antioxidant Properties
Trust Beta
Yang Qiu
Qin Liu
Anders Borgen
Franklin Brian Apea-Bah
List of Abbreviations
103(1)
Introduction
104(1)
Botanical Description
104(1)
Historical Cultivation of Purple Wheat
105(1)
Phenolic Compounds in Purple Wheat Seeds
105(4)
Methods of Analyses for Phenolic Contents and Phenolic Composition of Purple Wheat Seeds
109(5)
Total Phenolic Content and Phenolic Acid Composition
114(2)
Total Anthocyanin Content and Anthocyanin Composition
116(1)
Total Flavonoid Content and Proanthocyanidin Composition
117(1)
Processing and Utilization of Purple Wheat
117(2)
Applications to Health Promotion and Disease Prevention
119(3)
Adverse Effects and Reactions (Allergies and Toxicity)
122(1)
Summary Points and Future Perspectives
122(1)
References
123(4)
11 Protective Role of Nigella sativa and Thymoquinone in Oxidative Stress: A Review
Fatemeh Forouzanfar
Hossein Hosseinzadeh
Introduction
127(1)
Free Radicals and Antioxidant Defense
127(1)
Chemical Constituents
128(1)
Traditional Medicine
128(1)
Pharmacological Properties
128(1)
In vitro Antioxidant Activity of Nigella sativa
129(1)
In vivo Antioxidant Activity of Nigella sativa
130(10)
Conclusion
140(1)
References
141(6)
12 Black Soybean Seed: Black Soybean Seed Antioxidant Capacity
Ignasius Radix A.P. Jati
List of Abbreviations
147(1)
Introduction
147(1)
History, cultivation, and use
148(1)
Anthocyanin
149(1)
Antioxidant activity of black soybeans and black soybean---based food products
150(2)
Health-promoting and disease-preventing effects of black soybean seed
152(4)
Summary Points
156(1)
References
156(5)
13 Fenugreek (Trigonella foenum) Seeds in Health and Nutrition
Dilipkumar Pal
Souvik Mukherjec
Introduction
161(1)
Scientific Classification
162(1)
Morphology of Seed
162(1)
Earlier Cultivation of Fenugreek Seed
162(1)
Current Cultivation
162(3)
Phytochemical Constituents
165(1)
Therapeutic Potential of Fenugreekenugreek Seed
165(3)
Adverse Effects
168(1)
Conclusion
168(1)
References
168(3)
14 Tamarind (Tamarindiis indica) Seeds in Health and Nutrition
Dilipkumar Pal
Souvik Mukherjec
List of Abbreviations
171(1)
Introduction
171(1)
Botanical Description
172(1)
Vernacular Names
173(1)
Taxonomical Classification
174(1)
Historical Cultivation and Usage
174(1)
Present-Day Cultivation and Usage
175(1)
Nutritional Characterization of Tamarind Seeds
176(1)
Phytochemicals Composition of Tamarind Seed
177(1)
Biological Activities
177(1)
Tamarind Seed Polysaccharide: a Promising Natural Excipient for Pharmaceuticals
178(2)
Possible Adverse Effects and Reaction(s)
180(1)
Summary of Key Point(s)
180(1)
References
181(2)
15 Sesame Seed in Controlling Humar Health and Nutrition
Dilipkumar Pal
Phool Chandra
Nectu Sachan
List of Abbreviations
183(1)
Introduction
184(1)
Plant Profile
184(3)
Chemical Composition
187(6)
Pharmacological Applications
193(11)
Sesame Oil Protects Against Lead-Plus-Lipopolysaccharide-Induced Acute Hepatic Injury
204(2)
Conclusions
206(1)
References
206(5)
16 Kancolla Seeds: High Nutritional Foods With Nutraceutical Properties
Irene Dini
List of Abbreviations
211(1)
Introduction
211(1)
Nutritional Values of Kancolla Seeds
212(6)
Phytochemical Composition of Kancolla Seeds
218(2)
Triterpenoid Saponins
220(6)
References
226(3)
17 Health-promoting Potential and Nutritional Value of Madhuca longifolia Seeds
Mohamed Fawzy Ramadan
Enas Mohamed Wagdi Abdel-Hamed
List of Abbreviations
229(1)
Introduction
229(1)
Botanical Description and Cultivation
230(1)
Composition of M. longifolia Seeds and Seed Cake
230(1)
M. longifolia Butter Content and Composition
230(1)
Applications of M. longifolia Butter
233(1)
Applications of M. longifolia Seeds in Health Promotion and Disease Prevention
233(2)
Adverse Effects (Allergies and Toxicity)
235(1)
Conclusion
235(1)
References
236(5)
III Fungal Infections on Seeds and Nuts and Health
18 Ginkgo biloba Seeds: Antifungal and Lipid Transfer Proteins from Ginkgo biloba Nuts
Ken-ichi Hatano
Takuya Miyakawa
Masaru Tanokura
Introduction
241(2)
Lipid Transfer Proteins
243(5)
Antifungal Proteins
248(4)
Outlook
252(1)
References
252(3)
19 Mycotoxins in Nuts and Seeds
Elisabete Yurie Sataque Ono
Melissa Tiemi Hirozawa
Aline Myuki Omori
Andressa Jacqueline de Oliveira
Mario Augusto Ono
Introduction
255(2)
Natural Occunence
257(3)
Effect of Heat Processing
260(2)
Toxicological Effects in Humans
262(4)
Summary Points
266(1)
Acknowledgments
266(1)
References
267(6)
IV Nuts and Seeds in Disease Prevention and Therapy
20 Lepidium sativum Seeds: Therapeutic Significance and Health-Promoting Potential
Mohamed Fawzy Ramadan
Hesham F. Oraby
List of Abbreviations
273(1)
Introduction
273(1)
Botanical Description and Cultivation
274(1)
Chemical Composition of Lepidium sativum Seeds
275(2)
Amino Acids Profile
277(1)
Seed Oil Composition
278(1)
Edible Applications of Lepidium sativum
279(1)
Applications of Lepidium sativum to Health Promotion and Disease Prevention
279(1)
Application As An Excipient in Pharmaceutical Dosage Form
280(1)
Therapeutic Applications
281(4)
Adverse Effects (Allergies and Toxicity)
285(1)
Conclusions
285(1)
References
286(5)
21 The Effects of Nuts on Metabolic Diseases and Disorders
Mohammad Moradzad
List of Abbreviations
291(1)
Introduction
291(1)
Fats
292(1)
Macrominerals and Micromineral
293(1)
Phenolic Compounds
294(1)
Discussion
294(1)
References
295(4)
22 Tea (Camellia oleifera) Seeds: Use of Tea Seeds in Human Health
Chanya Chaicharocnpong
List of Abbreviations
299(1)
Introduction
300(1)
Botanical Description
300(1)
Historical Cultivation and Usage
300(1)
Present-day Cultivation and Usage
301(1)
Applications to Health Promotion and Disease Prevention
301(9)
Adverse Effects and Reactions (Allergies and Toxicity)
310(1)
Summary Points
311(1)
References
311(4)
23 Effect of Nigella sativa on Blood Diseases: A Review
Azar Hosseini
Hossein Hosseinzadeh
Introduction
315(1)
Effect of NigeUa sativa on Hematological Parameters
316(1)
Induction of Anemia by Chemical Compounds
316(5)
Clinical Studies
321(3)
Conclusion
324(1)
References
325(4)
24 Dermatological Effects of Nigella sativa and Its Constituent, Thymoquinone: A Review
Arezoo Rajabian
Hossein Hosseinzadeh
Introduction
329(9)
Methods
338(1)
Anti-inflammatory and Immunomodulatory Properties of NigeUa sativa and Its Constituent, TQ, Used to Treat Skin Ailments
339(1)
In vitro and in Vivo Preclinical Studies
339(1)
Clinical Studies
340(1)
Anticancer
341(1)
In vitro Studies
341(1)
In vivo Studies
342(1)
Wound Healing Effects
342(1)
In vivo Studies
342(1)
In vitro Studies
343(1)
Antimicrobial Properties Against Skin Relevant Pathogens
343(1)
Antibacterial
343(1)
In vitro Studies
343(1)
In vivo Studies
344(1)
Antifungal Effects
344(2)
Antiparasitic Properties
346(2)
Conclusion
348(1)
References
348(9)
25 Indian Mustard (Brassica juncea L.) Seeds in Health
Reka Szollosi
List of Abbreviations
357(1)
Introduction
357(1)
Botanical Descriptions
358(1)
Historical Cultivation and Usage
358(1)
Present-Day Cultivation and Usage
358(1)
Applications to Health Promotion and Disease Prevention
359(3)
Adverse Effects and Reactions (Allergies and Toxicity)
362(1)
Summary Points
362(1)
References
363(2)
26 Potential Role of Seeds From India in Diabetes
Kaveri Mahadev Adki
Ankit Pravin Laddha
Anil Bhanudas Gaikwad
Yogesh Anant Kulkarni
Introduction
365(1)
Seeds from Medicinal Plants and Their Role in Diabetes
366(21)
Conclusion
387(1)
References
388(5)
27 Lupine Seeds (Lupinus spp.): History of Use, Use as An Antihyperglycemic Medicinal, and Use as a Food Plant
Kathryn T. Knecht
Patricia Sanchez
David H. Kinder
List of Abbreviations
393(1)
Introduction
393(1)
Botanical Description
394(1)
Historical Medicinal Use
394(1)
Current Medicinal Applications
395(1)
Type 2 Diabetes
396(1)
Fiber
397(1)
Alkaloids
397(1)
DPP-IV Inhibitors
398(1)
Conglutins
398(1)
Hyperlipidemia
399(1)
Hypertension
399(1)
Adverse Effects
399(1)
Summary Points
400(1)
References
400(3)
28 Cancer Chemopreventive Potential of Seed Proteins and Peptides
Chia-Chien Hsieh
Blanca Hernandez-Ledcsma
Ben O. de Lumen
List of Abbreviations
403(1)
Introduction
403(11)
Acknowledgments
414(1)
References
414(7)
29 Use of Red Clover (Trifolium pratense L.) Seeds in Human Therapeutics
Hatice Colgecen
U. Koca
H.N. Buyiikkartal
List of Abbreviations
421(1)
Introduction
421(1)
Botanical Description
422(1)
Historical Cultivation and Usage
422(1)
Present-Day Cultivation and Usage
422(2)
Applications to Health Promotion and Disease Prevention
424(1)
Adverse Effects and Reactions, Allergies, and Toxicity
425(1)
Summary Points
426(1)
References
426(3)
30 Milk Thistle Seeds in Health
Sanjih Bhattacharya
List of Abbreviations
429(1)
Introduction
429(1)
Botanical Descriptions
430(1)
Historical Cultivation and Usage
431(1)
Present-day Cultivation and Usage
432(1)
Applications to Health Promotion and Disease Prevention
432(5)
Summary Points
437(1)
References
437(4)
V Extracts From Nuts and Seeds in Health
31 Nut Consumption and Noncommunicable Diseases: Evidence From Epidemiological Studies
Daniela Martini
Justyna Godos
Letizia Bresciani
Giuseppe Grosso
Introduction
441(1)
Nuts and Metabolic Disorders
442(4)
Nuts and Cardiovascular Disease Risk
446(1)
Nuts and Cancer Risk
447(1)
Nuts and Affective Disorders
448(1)
Nuts and Cognitive Disorders
448(1)
Conclusions
449(1)
References
449(4)
32 Beneficial Effects of Nuts From India in Cardiovascular Disorders
Ankit Pravin Laddha
Kaveri Mahadev Adki
Anil Bhanudas Gaikwad
Yogesh Anant Kulkami
List of Abbreviations
453(1)
Introduction
454(1)
Cardiovascular Disorder
455(1)
Almond and Cardiovascular Diseases
456(3)
Cashew Nuts and Cardiovascular Diseases
459(2)
Walnut and Cardiovascular Diseases
461(2)
Pistachios and Cardiovascular Diseases
463(3)
Peanuts and Cardiovascular Diseases
466(1)
Conclusion
466(1)
References
467(4)
33 Seeds as Herbal Drugs
Sanjib Bhattacharya
List of Abbreviations
471(1)
Introduction
471(1)
Medicinal Constituents of Seeds
472(1)
Factors Influencing Medicinal Properties of Seeds
472(1)
Seeds as Source of Medicinally Important Fixed Oils
473(3)
Seeds as Herbal Drugs and Source of Medicinally Active Compounds
476(6)
Summary Points
482(1)
References
483(2)
34 Therapeutic Importance of Caster Seed Oil
Vetriselvan Subramaniyan
List of Abbreviations
485(1)
Introduction
485(1)
Castor Oil Is Unique Among all Fats and Oils
486(3)
Soaps, Waxes, and Greases
489(1)
Pharmacological and Medicinal Use
489(1)
Other Health Benefits of Castor Oil
490(3)
Side Effects of Castor Oil
493(1)
References
493(4)
35 Coriandrum sativum L.: Characterization, Biological Activities, and Applications
Filomena Silva
Celia Domeno
Fernanda C. Domingues
Coriander Plant
497(1)
Coriander Oil and Extracts
498(5)
Coriander Biological Activities
503(8)
Uses of Coriander Oil and Extracts
511(3)
Concluding Remarks
514(1)
References
514(7)
36 Proteinase Inhibitors From Buckwheat (Fagoprum esculentum Moench) Seeds
Yakov E. Dunaevsky
Nacalya V. Khadeeva
Alexander A. Vassilevski
Valentina I. Domash
Mikhail A. Belozersky
List of Abbreviation
521(1)
Introduction
521(1)
Botanical Descriptions
522(1)
Present-day Cultivation and Usage
522(1)
Applications to Health Promotion and Disease Prevention
522(8)
Adverse Effects and Reactions (Allergies and Toxicity)
530(1)
Summary Points
530(1)
Acknowledgments
531(1)
References
531(2)
37 Pumpkin Seeds: Phenolic Acids in Pumpkin Seed (Cucurbita pepo L.)
Vera Krimer-Malesevic
List of Abbreviations
533(1)
Introduction
533(2)
Historical Cultivation and Usage
535(1)
Present-Day Cultivation and Usage
535(1)
Applications to Health Promotion and Disease Prevention
536(5)
Adverse Effects and Reactions (Allergies and Toxicity)
541(1)
Summary Points
541(1)
References
541(2)
38 Big Leaf Mahogany Seeds: Swietenia macrophylla Seeds Offer Possible Phytotherapeutic Intervention Against Diabetic Pathophysiology
Saikat Dewanjee
Paramita Paul
Tarun K. Dua
Shovonlal Bhowmick
Achintya Saha
List of Abbreviations
543(1)
Introduction
544(1)
Description and Distribution
544(1)
Ethnomedicinal Significance of Swietenia macrophylla Seeds
545(1)
Swietenia macrophylla Seeds as a Potential Phytotherapeutic Agent Against Diabetes
545(2)
Swietenia macrophylla Seeds Against Ailments Contribute in the Diabetic Pathogenesis
547(1)
Toxicities and Contraindications of Swietenia macrophylla Seeds
548(1)
Phytochemicals in Swietenia macrophylla Seeds
548(1)
Antidiabetic Phytochemicals in Swietenia macrophylla Seeds
549(6)
Metabolites in Swietenia macrophylla Seeds Against Pathogenesis Contribute in the Complications
555(1)
Predicted Molecular Interactions of Swietenine with Signal Proteins and Detection of Drug-likeness
556(1)
Molecular Docking
556(3)
In silico ADMET Prediction
559(1)
Conclusion
560(1)
References
561(6)
Index 567
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at Kings College Hospital and Emeritus Professor of Nutritional Biochemistry at Kings College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at Kings College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books. Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watsons career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models.