Contributors |
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xi | |
Preface |
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xv | |
Acknowledgments |
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xvii | |
I Polyphenols In The Prevention And Treatment Of Vascular And Cardiac Disease And Cancer |
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1 The Pharmacology of Avenanthramides: Polyphenols |
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3 | (12) |
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3 | (1) |
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2 Occurrence and Biosynthesis |
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3 | (2) |
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3 In Vitro Pharmacological Activities |
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5 | (3) |
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4 In Vivo Studies on Avenanthramides |
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8 | (2) |
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5 Pharmacokinetics, Biotransformation, and Bioavailibility |
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10 | (2) |
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12 | (1) |
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12 | (1) |
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12 | (3) |
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2 Folate Production by Lactic Acid Bacteria |
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15 | (16) |
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15 | (1) |
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2 Folate Metabolism and Bioavailability |
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16 | (2) |
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3 Folate Deficiencies: Implications in Health and Disease |
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18 | (3) |
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4 Folic Acid Fortification and Supplementation |
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21 | (1) |
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5 Folate Biosynthesis by Lactic Acid Bacteria |
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22 | (3) |
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25 | (1) |
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26 | (1) |
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26 | (3) |
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29 | (2) |
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3 A Triterpenoid Commonly Found in Human Diet: Ursolic Acid |
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31 | (6) |
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31 | (1) |
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2 Ursolic Acid and Health |
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31 | (3) |
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3 Toxic Effects of Ursolic Acid |
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34 | (1) |
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34 | (1) |
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35 | (2) |
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4 The Major Flavonoid of Grapefruit: Naringin |
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37 | (8) |
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37 | (1) |
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2 Bioavailability and Kinetics |
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37 | (1) |
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37 | (4) |
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4 Toxic Effects of Naringin |
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41 | (1) |
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41 | (1) |
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42 | (3) |
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5 Structural Evaluation and Toxicological Study of a Bitter Masking Bioactive Flavanone, 'Eriodictyol' |
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45 | (18) |
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45 | (3) |
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2 Materials and Methodology |
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48 | (1) |
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3 Results and Discussions |
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48 | (10) |
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58 | (1) |
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58 | (1) |
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58 | (5) |
II Cardiac Health And Polyphenols |
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6 Postprandial Effects of Wine Consumption Along With a Meal on the Main Pathophysiological Systems |
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63 | (14) |
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63 | (2) |
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2 Postprandial State and Atherosclerosis |
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65 | (1) |
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3 Postprandial Interventions |
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66 | (7) |
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73 | (1) |
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74 | (3) |
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7 Cellular and Molecular Mechanisms of Polyphenol-Induced Beneficial Effects on Cardiac Remodeling |
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77 | (12) |
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1 Introduction to Pathological Cardiac Remodeling |
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77 | (1) |
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2 Beneficial Effects of Polyphenols in Cardiac Remodeling |
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78 | (2) |
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3 Effects of Polyphenols on Signaling Pathways Involved in Cardiac Remodeling |
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80 | (2) |
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4 Polyphenols and Intracellular Calcium Handling |
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82 | (1) |
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5 Polyphenols and Cardiac Fibrosis |
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83 | (1) |
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6 Polyphenols and Autophagy in Cardiac Myocytes |
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83 | (1) |
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7 Polyphenols and Epigenetic Mechanisms in Cardiac Remodeling |
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84 | (1) |
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85 | (1) |
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85 | (1) |
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85 | (1) |
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85 | (4) |
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8 Effect of Cranberry Polyphenols and Metabolites on Microbial Activity and Impact on Urinary Tract Health |
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89 | (18) |
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89 | (1) |
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89 | (1) |
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3 Absorption, Metabolism and Bioavailability of Cranberry Polyphenols |
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90 | (5) |
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4 Urinary Tract Infection Cycle |
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95 | (2) |
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5 Cranberry Components and Mechanisms of Action |
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97 | (4) |
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101 | (1) |
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102 | (1) |
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102 | (3) |
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105 | (2) |
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9 Cranberry Polyphenols: Effects on Cardiovascular Risk Factors |
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107 | (18) |
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107 | (1) |
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108 | (2) |
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3 Total Phenolic Content of Cranberry Products |
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110 | (1) |
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4 In Vitro Antioxidant Capacity and Cranberry Composition |
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110 | (2) |
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5 Polyphenols and Cardiovascular Health |
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112 | (1) |
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6 Cranberry Polyphenols and Cardiovascular Health |
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113 | (5) |
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118 | (1) |
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118 | (4) |
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122 | (3) |
III Cancer Prevention And Treatment By Polyphenols |
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10 An Insight of Polyphenols in Lung Cancer Chemoprevention |
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125 | (12) |
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125 | (1) |
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126 | (1) |
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3 Polyphenols and Lung Cancer |
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127 | (6) |
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133 | (1) |
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133 | (4) |
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11 Mushroom Polyphenols as Chemopreventive Agents |
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137 | (14) |
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137 | (1) |
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2 Phenolic Compounds in Mushrooms |
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138 | (2) |
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3 Review of In Vitro Studies on Chemopreventive Phenolics in Mushrooms |
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140 | (1) |
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4 Review of In Vivo Studies on Chemopreventive Phenolics in Mushrooms |
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140 | (7) |
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147 | (1) |
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147 | (4) |
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12 Pleiotropic Molecular Effects of Dietary Polyphenols Resveratrol and Apigenin in Leukemia |
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151 | (12) |
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151 | (1) |
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2 Therapeutic Potential of Resveratrol in Cancer |
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152 | (1) |
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3 Molecular Targets of Resveratrol in Leukemia |
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153 | (4) |
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4 The Importance of Apigenin in Human Health |
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157 | (2) |
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159 | (1) |
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160 | (3) |
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13 The Polyphenolic Compound Apigenin and Applications to Cervical Cancer |
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163 | (10) |
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163 | (1) |
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2 Cervical Cancer Natural History |
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164 | (1) |
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3 Invasive Cervical Cancer Treatment/Intervention Modalities |
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164 | (2) |
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4 Chemotherapy Drugs Currently Available for the Treatment of Invasive Cervical Cancer |
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166 | (1) |
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5 Naturally Occurring Compounds and Applications to Invasive Cervical Cancer |
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166 | (1) |
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6 The Polyphenolic Compound Apigenin and Applications to Cervical Cancer |
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167 | (3) |
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170 | (1) |
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170 | (3) |
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14 An Outside-In and a Reciprocal Inside-Out Hypothesis Combining Resveratrol and Its High Affinity Protein NQO2 to Target iASPP for Reinstating the Activation and Stabilization of Dysfunctional WTp53 as a Melanoma Chemopreventive Approach |
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173 | (12) |
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173 | (1) |
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2 Skin Cancer, Especially Melanoma, Remains a Public Health Challenge in the United States |
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174 | (1) |
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3 UV Exposure and Risk of Melanomagenesis |
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175 | (1) |
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4 Role p53, ASPP, and iASPP Play in Melanomagenesis |
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176 | (1) |
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5 p53 and iASPP are Targets of Resveratrol and Other Dietary Polyphenols in the Prevention of Melanomagenesis |
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177 | (4) |
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181 | (1) |
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181 | (4) |
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15 Counteracting Resistance to BRAF V600E Mutation in Melanoma Using Dietary Polyphenols |
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185 | (10) |
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185 | (1) |
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186 | (1) |
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3 BRAF Mutation in Human Cancer and Melanoma |
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186 | (3) |
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4 Overcoming Resistance to BRAF V600E Mutations in Melanoma With Dietary Agents-Blockade of De Novo Acquired Resistance by Cotargeting Inhibition of MEK1 and ERK Using Dietary Phytochemicals |
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189 | (1) |
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5 Perspectives and Conclusion |
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190 | (2) |
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192 | (3) |
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16 Role of Natural Compounds in Prevention and Treatment of Chronic Lymphocytic Leukemia |
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195 | (10) |
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195 | (1) |
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2 Chronic Lymphocytic Leukemia |
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196 | (1) |
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3 Novel Targets for CLL Therapy |
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196 | (1) |
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4 Natural Compounds for CLL Treatment |
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196 | (5) |
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201 | (1) |
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201 | (4) |
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17 Polyphenols and Breast Cancer Prevention-A Summary of the Epidemiologic Evidence |
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205 | (12) |
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205 | (1) |
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2 Human Consumption of Plant Food Phenols |
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205 | (3) |
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3 Breast Cancer Risk Related to Different Classes of Polyphenols |
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208 | (4) |
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4 Breast Cancer Risk Related to Polyphenol Containing Beverages |
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212 | (1) |
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213 | (1) |
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213 | (1) |
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214 | (3) |
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18 Resveratrol Inhibitory Effects Against a Malignant Tumor: A Molecular Insight |
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217 | (14) |
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217 | (1) |
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2 Resveratrol Characteristics Summary |
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217 | (2) |
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3 Cancer Cell Characterization and Resveratrol Action |
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219 | (1) |
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4 Regulation of the Cell Cycle and Transcription Factors by Resveratrol |
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219 | (3) |
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5 Cell Cytoskeleton and Migration Implemented by Resveratrol |
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222 | (2) |
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6 Mitochondrial Function Regulated by Resveratrol |
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224 | (1) |
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7 Apoptosis Induced by Resveratrol |
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225 | (1) |
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8 Anticancer Sensitization Effects of Resveratrol |
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226 | (1) |
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226 | (1) |
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226 | (5) |
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19 Biological Activity of Resveratrol on an Ovarian Cancer Cell |
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231 | (16) |
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1 Ovarian Cancer Overview |
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231 | (1) |
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2 The Management of Ovarian Cancer |
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232 | (1) |
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3 Angiogenesis-Inhibiting Treatment in Ovarian Cancer Patients |
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233 | (1) |
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4 Maintenance Treatment of Ovarian Cancer With Mutated BRCA Genes |
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233 | (2) |
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5 Ovarian Cancer Growth Inhibition and Apoptosis Induced by Resveratrol |
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235 | (3) |
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6 Regulatory Functions of Resveratrol on Ovarian Cancer Cell Cycle and Transcriptional Factors |
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238 | (2) |
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7 Glucose Metabolism in Ovarian Cancer Cell and Resveratrol |
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240 | (1) |
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241 | (1) |
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241 | (6) |
IV Inflammation And Immune Function: Polyphenols |
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20 Antiarthritic Effects of Turmeric and Curcumin: A Revisit |
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247 | (6) |
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Benson Mathai Kochikuzhyil |
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Manjeshwar Shrinath Baliga |
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247 | (1) |
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247 | (3) |
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250 | (1) |
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251 | (2) |
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21 Effects of Polyphenols on Inflammatory-Allergic Conditions: Experimental and Clinical Evidences |
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253 | (10) |
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253 | (5) |
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258 | (1) |
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258 | (1) |
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259 | (2) |
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261 | (2) |
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22 Polyphenols and Immune System |
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263 | (16) |
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264 | (10) |
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274 | (1) |
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274 | (5) |
V Gastrointestinal, Liver Health And Polyphenols |
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23 Antioxidants and Polyphenols in Inflammatory Bowel Disease: Ulcerative Colitis and Crohn Disease |
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279 | (14) |
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1 The Pathogenesis of UC and CD |
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279 | (2) |
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2 Reactive Oxygen Species in Ulcerative Colitis and Crohn Disease |
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281 | (2) |
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3 Oxidants and Antioxidants and Role of Polyphenols in the Experimental Colitis |
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283 | (6) |
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4 Antioxidants in Human IBD |
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289 | (1) |
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290 | (2) |
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292 | (1) |
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24 Red Propolis: Phenolics, Polyphenolics, and Applications to Microbiological Health and Disease |
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293 | (8) |
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293 | (1) |
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2 Propolis Chemical Composition |
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293 | (2) |
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3 Red Propolis Biological Activity |
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295 | (2) |
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4 Clinical Use of Red Propolis and Its Isolated Molecules |
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297 | (1) |
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298 | (1) |
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298 | (3) |
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25 Viral Disease and Use of Polyphenolic Compounds |
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301 | (12) |
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301 | (1) |
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2 The Replication Cycle of Virus and the Target of Antiviral Activity |
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302 | (3) |
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3 Antiviral Polyphenol Compounds Against RNA Viruses |
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305 | (4) |
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4 Antiviral Polyphenol Compounds Against DNA Viruses |
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309 | (2) |
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311 | (1) |
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311 | (2) |
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26 Hepatoprotective Effects of Curcumin in Alcohol-Induced Hepatotoxicity: A Memoir on the Preclinical Studies |
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313 | (6) |
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Manjeshwar Shrinath Baliga |
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313 | (1) |
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2 Curcumin in the Protection of Alcohol-Induced Hepatotoxicity |
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314 | (1) |
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3 Turmeric in Traditional Medicine |
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314 | (1) |
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4 Curcumin Is a Pleiotropic Pharmacological Polyphenol |
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315 | (1) |
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5 Curcumin Protects Against Alcohol-Induced Hepatotoxicity |
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315 | (1) |
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316 | (1) |
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316 | (3) |
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27 Turmeric and Its Principal Polyphenol Curcumin as a Nontoxic Gastroprotective Agent: Recent Update |
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319 | (8) |
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Holalu Shivashankaregowda Yashavanth |
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Manjeshwar Shrinath Baliga |
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319 | (1) |
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2 Plants as Gastroprotective Agent |
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319 | (4) |
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323 | (1) |
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323 | (2) |
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325 | (2) |
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28 Anti-inflammatory, Immunomodulatory, and Prebiotic Properties of Dietary Flavonoids |
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327 | (22) |
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M. Victoria Garcia-Mediavilla |
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327 | (1) |
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2 In Vitro and Animal Studies |
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328 | (5) |
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333 | (6) |
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339 | (1) |
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340 | (1) |
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340 | (9) |
VI Polyphenols And Skin |
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29 Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis |
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349 | (36) |
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Lars Porskjaer Christensen |
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349 | (1) |
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2 Allergic Contact Dermatitis |
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350 | (22) |
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3 Photocontact Dermatitis |
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372 | (3) |
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4 Irritant Contact Dermatitis |
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375 | (1) |
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5 Inhibition of Skin Inflammation and Contact Dermatitis |
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375 | (4) |
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379 | (6) |
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30 Plant Polyphenols: The Futuristic Bioactive Therapeutics for Skin Care |
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385 | (10) |
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385 | (1) |
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386 | (1) |
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3 Phytometabolites Vis-a-Vis Traditional System of Medicine |
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386 | (1) |
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4 Concept of Cosmeceuticals |
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387 | (1) |
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5 Skin as Important Organ Vis-a-Vis Environmental Hazards |
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387 | (1) |
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6 Antiskin Aging and Antiacne Effects |
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388 | (1) |
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7 Anticancer and Antitumor Attributes |
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389 | (1) |
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8 Polyphenols Against Skin Parasites and Pathogens |
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390 | (1) |
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9 Antiviral Effects of Polyphenols |
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390 | (1) |
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10 Nanotechnology and Drug Nanocarriers for Polyphenols |
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390 | (1) |
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11 Opportunities, Challenges, and Conclusions |
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391 | (1) |
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392 | (3) |
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31 Antiinflammatory Activity of Polyphenols on Dendritic Cells |
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395 | (24) |
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395 | (1) |
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2 Immunobiology of Dendritic Cells |
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395 | (9) |
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3 Modulation of DC Activation and Function by Polyphenols |
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404 | (7) |
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411 | (1) |
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411 | (1) |
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411 | (4) |
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415 | (4) |
VII Polyphenols And Health |
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32 Effects and Usage of a Citrus Compound, Limonene |
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419 | (6) |
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419 | (1) |
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2 Bioavailability and Kinetics |
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419 | (1) |
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419 | (3) |
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4 Toxic Effects of Limonene |
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422 | (1) |
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423 | (1) |
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423 | (2) |
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33 A Phytoestrogen Puerarin and Its Health Effects |
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425 | (8) |
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425 | (1) |
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2 Bioavailability and Kinetics |
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425 | (1) |
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425 | (4) |
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4 Toxic Effects of Puerarin |
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429 | (1) |
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429 | (1) |
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429 | (4) |
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34 Galangin as a Plant Phenolic and Usage in Health and Disease |
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433 | (6) |
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433 | (1) |
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2 Bioavailability and Kinetics of Galangin |
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433 | (1) |
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433 | (4) |
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4 Toxic Effects of Galangin |
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437 | (1) |
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437 | (1) |
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437 | (2) |
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35 Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome? |
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439 | (16) |
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439 | (2) |
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2 Dyrk la and DS Phenotypes |
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441 | (1) |
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3 Treatment of Cognitive DS Phenotypes with EGCG |
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441 | (4) |
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4 Clinical Trials of Green Tea Extracts to Correct Cognitive Deficits in Individuals With DS |
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445 | (1) |
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5 The Use of EGCG to Potentially Correct Other Phenotypes Related to DS |
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446 | (2) |
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6 Why All of the Differences in the Effects of EGCG in Different Studies? |
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448 | (3) |
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451 | (1) |
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451 | (1) |
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451 | (4) |
Index |
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455 | |