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E-raamat: Polyphenols: Prevention and Treatment of Human Disease

Edited by (Professor, Department of Clinical Biochemistry, Kings College Hospital, London), Edited by , Edited by (Professor, Mel and Enid Zuckerman College of Public Health and School of Medicine, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA)
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  • Ilmumisaeg: 06-Aug-2018
  • Kirjastus: Academic Press Inc
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  • ISBN-13: 9780128130094
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  • Kirjastus: Academic Press Inc
  • Keel: eng
  • ISBN-13: 9780128130094
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Polyphenols in Prevention and Treatment of Human Disease, Second Edition authoritatively covers evidence of the powerful health benefits of polyphenols, touching on cardiovascular disease, cancer, obesity, diabetes and osteoporosis. This collection represents the contributions of an international group of experts in polyphenol research who share their expertise in endocrinology, public health, cardiology, pharmacology, agriculture and veterinary science. Researchers from diverse backgrounds will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted insights into the mechanisms of disease.

This reference fills a void in research where nutritionists and alternative therapies may be applicable.

  • Describes polyphenol modulation of blood flow and oxygenation as a potential mechanism of protection against vascular atherosclerosis
  • Describes how polyphenols and antioxidants frequently change immune defenses and actions
  • Focuses on the most important areas of research and provides insights into their relationships and translational opportunities
Contributors xi
Preface xv
Acknowledgments xvii
I Polyphenols In The Prevention And Treatment Of Vascular And Cardiac Disease And Cancer
1 The Pharmacology of Avenanthramides: Polyphenols
3(12)
Ilias Marmouzi
Shahira M. Ezzat
1 Introduction
3(1)
2 Occurrence and Biosynthesis
3(2)
3 In Vitro Pharmacological Activities
5(3)
4 In Vivo Studies on Avenanthramides
8(2)
5 Pharmacokinetics, Biotransformation, and Bioavailibility
10(2)
6 Conclusion
12(1)
Acknowledgments
12(1)
References
12(3)
2 Folate Production by Lactic Acid Bacteria
15(16)
Graciela Savoy De Giori
Jean Guy LeBlanc
1 Introduction
15(1)
2 Folate Metabolism and Bioavailability
16(2)
3 Folate Deficiencies: Implications in Health and Disease
18(3)
4 Folic Acid Fortification and Supplementation
21(1)
5 Folate Biosynthesis by Lactic Acid Bacteria
22(3)
6 Conclusions
25(1)
Acknowledgments
26(1)
References
26(3)
Further Reading
29(2)
3 A Triterpenoid Commonly Found in Human Diet: Ursolic Acid
31(6)
Merve Bacanli
A. Ahmet Basaran
Nursen Basaran
1 General Information
31(1)
2 Ursolic Acid and Health
31(3)
3 Toxic Effects of Ursolic Acid
34(1)
4 Conclusions
34(1)
References
35(2)
4 The Major Flavonoid of Grapefruit: Naringin
37(8)
Merve Bacanli
A. Ahmet Basaran
Nursen Basaran
1 General Information
37(1)
2 Bioavailability and Kinetics
37(1)
3 Naringin and Health
37(4)
4 Toxic Effects of Naringin
41(1)
5 Conclusion
41(1)
References
42(3)
5 Structural Evaluation and Toxicological Study of a Bitter Masking Bioactive Flavanone, 'Eriodictyol'
45(18)
Vijisha K. Rajan
K. Muraleedharan
K.P. Safna Hussan
1 Introduction
45(3)
2 Materials and Methodology
48(1)
3 Results and Discussions
48(10)
4 Conclusion
58(1)
Acknowledgments
58(1)
References
58(5)
II Cardiac Health And Polyphenols
6 Postprandial Effects of Wine Consumption Along With a Meal on the Main Pathophysiological Systems
63(14)
E. Fragopoulou
S. Antonopoulou
1 Introduction
63(2)
2 Postprandial State and Atherosclerosis
65(1)
3 Postprandial Interventions
66(7)
4 Conclusions
73(1)
References
74(3)
7 Cellular and Molecular Mechanisms of Polyphenol-Induced Beneficial Effects on Cardiac Remodeling
77(12)
Fan Jiang
1 Introduction to Pathological Cardiac Remodeling
77(1)
2 Beneficial Effects of Polyphenols in Cardiac Remodeling
78(2)
3 Effects of Polyphenols on Signaling Pathways Involved in Cardiac Remodeling
80(2)
4 Polyphenols and Intracellular Calcium Handling
82(1)
5 Polyphenols and Cardiac Fibrosis
83(1)
6 Polyphenols and Autophagy in Cardiac Myocytes
83(1)
7 Polyphenols and Epigenetic Mechanisms in Cardiac Remodeling
84(1)
8 Conclusion Remarks
85(1)
Acknowledgments
85(1)
Conflict of Interests
85(1)
References
85(4)
8 Effect of Cranberry Polyphenols and Metabolites on Microbial Activity and Impact on Urinary Tract Health
89(18)
Christina Khoo
Haiyan Liu
1 Introduction
89(1)
2 Cranberry Polyphenols
89(1)
3 Absorption, Metabolism and Bioavailability of Cranberry Polyphenols
90(5)
4 Urinary Tract Infection Cycle
95(2)
5 Cranberry Components and Mechanisms of Action
97(4)
6 Clinical Outcomes
101(1)
7 Summary
102(1)
References
102(3)
Glossary
105(2)
9 Cranberry Polyphenols: Effects on Cardiovascular Risk Factors
107(18)
Christina Khoo
Michael Falk
Jun Zhang
1 Introduction
107(1)
2 Cranberry Polyphenols
108(2)
3 Total Phenolic Content of Cranberry Products
110(1)
4 In Vitro Antioxidant Capacity and Cranberry Composition
110(2)
5 Polyphenols and Cardiovascular Health
112(1)
6 Cranberry Polyphenols and Cardiovascular Health
113(5)
7 Summary
118(1)
References
118(4)
Further Reading
122(3)
III Cancer Prevention And Treatment By Polyphenols
10 An Insight of Polyphenols in Lung Cancer Chemoprevention
125(12)
Vasanti Suvarna
Pramila Chaubey
Preeti C. Sangave
Ashish K. Singh
1 Introduction
125(1)
2 Chemoprevention
126(1)
3 Polyphenols and Lung Cancer
127(6)
4 Conclusion
133(1)
References
133(4)
11 Mushroom Polyphenols as Chemopreventive Agents
137(14)
Natalia Nowacka-Jechalke
Marta Olech
Renata Nowak
1 Introduction
137(1)
2 Phenolic Compounds in Mushrooms
138(2)
3 Review of In Vitro Studies on Chemopreventive Phenolics in Mushrooms
140(1)
4 Review of In Vivo Studies on Chemopreventive Phenolics in Mushrooms
140(7)
5 Conclusions
147(1)
References
147(4)
12 Pleiotropic Molecular Effects of Dietary Polyphenols Resveratrol and Apigenin in Leukemia
151(12)
Aysun Adan
Osman Oguz
1 Introduction
151(1)
2 Therapeutic Potential of Resveratrol in Cancer
152(1)
3 Molecular Targets of Resveratrol in Leukemia
153(4)
4 The Importance of Apigenin in Human Health
157(2)
5 Conclusion
159(1)
References
160(3)
13 The Polyphenolic Compound Apigenin and Applications to Cervical Cancer
163(10)
Raquel Pantarotto Souza
Marcia Edilaine
Lopes Consolaro
1 Introduction
163(1)
2 Cervical Cancer Natural History
164(1)
3 Invasive Cervical Cancer Treatment/Intervention Modalities
164(2)
4 Chemotherapy Drugs Currently Available for the Treatment of Invasive Cervical Cancer
166(1)
5 Naturally Occurring Compounds and Applications to Invasive Cervical Cancer
166(1)
6 The Polyphenolic Compound Apigenin and Applications to Cervical Cancer
167(3)
7 Conclusion
170(1)
References
170(3)
14 An Outside-In and a Reciprocal Inside-Out Hypothesis Combining Resveratrol and Its High Affinity Protein NQO2 to Target iASPP for Reinstating the Activation and Stabilization of Dysfunctional WTp53 as a Melanoma Chemopreventive Approach
173(12)
Tze-Chen Hsieh
Barbara B. Doonan
Joseph M. Wu
1 Introduction
173(1)
2 Skin Cancer, Especially Melanoma, Remains a Public Health Challenge in the United States
174(1)
3 UV Exposure and Risk of Melanomagenesis
175(1)
4 Role p53, ASPP, and iASPP Play in Melanomagenesis
176(1)
5 p53 and iASPP are Targets of Resveratrol and Other Dietary Polyphenols in the Prevention of Melanomagenesis
177(4)
6 Conclusion
181(1)
References
181(4)
15 Counteracting Resistance to BRAF V600E Mutation in Melanoma Using Dietary Polyphenols
185(10)
Tze-Chen Hsieh
Barbara B. Doonan
Andrea Aquilato
Joseph M. Wu
1 Introduction
185(1)
2 Discovery of BRAF
186(1)
3 BRAF Mutation in Human Cancer and Melanoma
186(3)
4 Overcoming Resistance to BRAF V600E Mutations in Melanoma With Dietary Agents-Blockade of De Novo Acquired Resistance by Cotargeting Inhibition of MEK1 and ERK Using Dietary Phytochemicals
189(1)
5 Perspectives and Conclusion
190(2)
References
192(3)
16 Role of Natural Compounds in Prevention and Treatment of Chronic Lymphocytic Leukemia
195(10)
Ahmad Salimi
Jalal Pourahmad
1 Introduction
195(1)
2 Chronic Lymphocytic Leukemia
196(1)
3 Novel Targets for CLL Therapy
196(1)
4 Natural Compounds for CLL Treatment
196(5)
5 Conclusions
201(1)
References
201(4)
17 Polyphenols and Breast Cancer Prevention-A Summary of the Epidemiologic Evidence
205(12)
Gertraud Maskarinec
Cherie Guillermo
1 Introduction
205(1)
2 Human Consumption of Plant Food Phenols
205(3)
3 Breast Cancer Risk Related to Different Classes of Polyphenols
208(4)
4 Breast Cancer Risk Related to Polyphenol Containing Beverages
212(1)
5 Biomarker Studies
213(1)
6 Conclusions
213(1)
References
214(3)
18 Resveratrol Inhibitory Effects Against a Malignant Tumor: A Molecular Insight
217(14)
Gabriel Wcislo
1 Cancer Burden
217(1)
2 Resveratrol Characteristics Summary
217(2)
3 Cancer Cell Characterization and Resveratrol Action
219(1)
4 Regulation of the Cell Cycle and Transcription Factors by Resveratrol
219(3)
5 Cell Cytoskeleton and Migration Implemented by Resveratrol
222(2)
6 Mitochondrial Function Regulated by Resveratrol
224(1)
7 Apoptosis Induced by Resveratrol
225(1)
8 Anticancer Sensitization Effects of Resveratrol
226(1)
9 Conclusion
226(1)
References
226(5)
19 Biological Activity of Resveratrol on an Ovarian Cancer Cell
231(16)
Gabriel Wcislo
Agnieszka Synowiec
Katarzyna Szarlej-Wcislo
Lubomir Bodnar
1 Ovarian Cancer Overview
231(1)
2 The Management of Ovarian Cancer
232(1)
3 Angiogenesis-Inhibiting Treatment in Ovarian Cancer Patients
233(1)
4 Maintenance Treatment of Ovarian Cancer With Mutated BRCA Genes
233(2)
5 Ovarian Cancer Growth Inhibition and Apoptosis Induced by Resveratrol
235(3)
6 Regulatory Functions of Resveratrol on Ovarian Cancer Cell Cycle and Transcriptional Factors
238(2)
7 Glucose Metabolism in Ovarian Cancer Cell and Resveratrol
240(1)
8 Conclusion
241(1)
References
241(6)
IV Inflammation And Immune Function: Polyphenols
20 Antiarthritic Effects of Turmeric and Curcumin: A Revisit
247(6)
Naveen Mathai
Dargi Sony
Prajwal Prabhudev Mane
Chetan B. Shetty
Latheesh Latheef
Krithika Kamath
Mohd Khaleed
Benson Mathai Kochikuzhyil
Manjeshwar Shrinath Baliga
1 Introduction
247(1)
2 Plants in Arthritis
247(3)
3 Conclusions
250(1)
References
251(2)
21 Effects of Polyphenols on Inflammatory-Allergic Conditions: Experimental and Clinical Evidences
253(10)
Thea Magrone
Emilio Jirillo
1 Introduction
253(5)
2 Conclusion
258(1)
Acknowledgments
258(1)
References
259(2)
Further Reading
261(2)
22 Polyphenols and Immune System
263(16)
Ishak Ozel Tekin
Francesco Marotta
1 Introduction
264(10)
2 Conclusion
274(1)
References
274(5)
V Gastrointestinal, Liver Health And Polyphenols
23 Antioxidants and Polyphenols in Inflammatory Bowel Disease: Ulcerative Colitis and Crohn Disease
279(14)
Hitoshi Asakura
Tetsuji Kitahora
1 The Pathogenesis of UC and CD
279(2)
2 Reactive Oxygen Species in Ulcerative Colitis and Crohn Disease
281(2)
3 Oxidants and Antioxidants and Role of Polyphenols in the Experimental Colitis
283(6)
4 Antioxidants in Human IBD
289(1)
References
290(2)
Further Reading
292(1)
24 Red Propolis: Phenolics, Polyphenolics, and Applications to Microbiological Health and Disease
293(8)
Irlan A. Freires
Joao M.S. Pingueiro
Stela L.F. Miranda
Bruno Bueno-Silva
1 Introduction
293(1)
2 Propolis Chemical Composition
293(2)
3 Red Propolis Biological Activity
295(2)
4 Clinical Use of Red Propolis and Its Isolated Molecules
297(1)
5 Concluding Remarks
298(1)
References
298(3)
25 Viral Disease and Use of Polyphenolic Compounds
301(12)
Dong Joo Seo
Changsun Choi
1 Polyphenolic Compounds
301(1)
2 The Replication Cycle of Virus and the Target of Antiviral Activity
302(3)
3 Antiviral Polyphenol Compounds Against RNA Viruses
305(4)
4 Antiviral Polyphenol Compounds Against DNA Viruses
309(2)
5 Conclusion
311(1)
References
311(2)
26 Hepatoprotective Effects of Curcumin in Alcohol-Induced Hepatotoxicity: A Memoir on the Preclinical Studies
313(6)
Manjeshwar Shrinath Baliga
Suresh Rao
Pratima Rao
Michael L.J. Pais
Taresh Shekar Naik
Mohammed Adnan
Princy Louis Palatty
1 Introduction
313(1)
2 Curcumin in the Protection of Alcohol-Induced Hepatotoxicity
314(1)
3 Turmeric in Traditional Medicine
314(1)
4 Curcumin Is a Pleiotropic Pharmacological Polyphenol
315(1)
5 Curcumin Protects Against Alcohol-Induced Hepatotoxicity
315(1)
6 Conclusions
316(1)
References
316(3)
27 Turmeric and Its Principal Polyphenol Curcumin as a Nontoxic Gastroprotective Agent: Recent Update
319(8)
Holalu Shivashankaregowda Yashavanth
Raghavendra Haniadka
Suresh Rao
Pratima Rao
Ashwin Alva
Princy Louis Palatty
Manjeshwar Shrinath Baliga
1 Introduction
319(1)
2 Plants as Gastroprotective Agent
319(4)
3 Conclusions
323(1)
References
323(2)
Further Reading
325(2)
28 Anti-inflammatory, Immunomodulatory, and Prebiotic Properties of Dietary Flavonoids
327(22)
Javier Gonzalez-Gallego
M. Victoria Garcia-Mediavilla
Sonia Sanchez-Campos
Maria J. Tunon
1 Introduction
327(1)
2 In Vitro and Animal Studies
328(5)
3 Human Studies
333(6)
4 Conclusions
339(1)
Conflict of Interest
340(1)
References
340(9)
VI Polyphenols And Skin
29 Polyphenols and Polyphenol-Derived Compounds From Plants and Contact Dermatitis
349(36)
Lars Porskjaer Christensen
1 Introduction
349(1)
2 Allergic Contact Dermatitis
350(22)
3 Photocontact Dermatitis
372(3)
4 Irritant Contact Dermatitis
375(1)
5 Inhibition of Skin Inflammation and Contact Dermatitis
375(4)
References
379(6)
30 Plant Polyphenols: The Futuristic Bioactive Therapeutics for Skin Care
385(10)
B. Singh
G. Mal
D. Sharma
S.K. Gautam
M. Kumar
U. Solimene
M. Metalla
Francesco Marotta
1 Introduction
385(1)
2 Types of Polyphenols
386(1)
3 Phytometabolites Vis-a-Vis Traditional System of Medicine
386(1)
4 Concept of Cosmeceuticals
387(1)
5 Skin as Important Organ Vis-a-Vis Environmental Hazards
387(1)
6 Antiskin Aging and Antiacne Effects
388(1)
7 Anticancer and Antitumor Attributes
389(1)
8 Polyphenols Against Skin Parasites and Pathogens
390(1)
9 Antiviral Effects of Polyphenols
390(1)
10 Nanotechnology and Drug Nanocarriers for Polyphenols
390(1)
11 Opportunities, Challenges, and Conclusions
391(1)
References
392(3)
31 Antiinflammatory Activity of Polyphenols on Dendritic Cells
395(24)
V. Francisco
G. Costa
B.M. Neves
M.T. Cruz
M.T. Batista
1 Introduction
395(1)
2 Immunobiology of Dendritic Cells
395(9)
3 Modulation of DC Activation and Function by Polyphenols
404(7)
4 Future Perspectives
411(1)
Acknowledgments
411(1)
References
411(4)
Further Reading
415(4)
VII Polyphenols And Health
32 Effects and Usage of a Citrus Compound, Limonene
419(6)
Merve Bacanli
A. Ahmet Basaran
Nursen Basaran
1 General Information
419(1)
2 Bioavailability and Kinetics
419(1)
3 Limonene and Health
419(3)
4 Toxic Effects of Limonene
422(1)
5 Conclusion
423(1)
References
423(2)
33 A Phytoestrogen Puerarin and Its Health Effects
425(8)
Merve Bacanli
Sevtap Aydin
A. Ahmet Basaran
Nursen Basaran
1 General Information
425(1)
2 Bioavailability and Kinetics
425(1)
3 Puerarin and Health
425(4)
4 Toxic Effects of Puerarin
429(1)
5 Conclusion
429(1)
References
429(4)
34 Galangin as a Plant Phenolic and Usage in Health and Disease
433(6)
Merve Bacanli
A. Ahmet Basaran
Nursen Basaran
1 General Information
433(1)
2 Bioavailability and Kinetics of Galangin
433(1)
3 Galangin and Health
433(4)
4 Toxic Effects of Galangin
437(1)
5 Conclusions
437(1)
References
437(2)
35 Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome?
439(16)
Randall J. Roper
Charles R. Goodlett
1 Down Syndrome
439(2)
2 Dyrk la and DS Phenotypes
441(1)
3 Treatment of Cognitive DS Phenotypes with EGCG
441(4)
4 Clinical Trials of Green Tea Extracts to Correct Cognitive Deficits in Individuals With DS
445(1)
5 The Use of EGCG to Potentially Correct Other Phenotypes Related to DS
446(2)
6 Why All of the Differences in the Effects of EGCG in Different Studies?
448(3)
7 Conclusions
451(1)
Acknowledgments
451(1)
References
451(4)
Index 455
Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watsons career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at Kings College Hospital and Emeritus Professor of Nutritional Biochemistry at Kings College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at Kings College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books. Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadis research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.