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E-book: Biomaterials in Translational Medicine

Edited by (Professor, Orthopaedic Institute and the Department of Orthopaedics, the First Affiliated Hospital, Soochow University, China), Edited by (School of), Edited by (Professor & Director, Multi-functional Materials Laboratory, Departments of MIME and Surgery)
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Translational Medicine: A Biomaterials Approach delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine.

  • Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine
  • Includes the translational or commercialization status of these new biomaterials
  • Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine
  • Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials
List of Contributors
xi
Foreword xv
Preface xvii
1 Translational medicine and biomaterials: Basics and relationship
1(22)
Amit K. Roy
Akhenaton-Andrew D. Jones III
Thomas J. Webster
1.1 Overview of biomaterials in translational medicine
1(3)
1.2 Fundamentals of translational medicine
4(3)
1.2.1 Definitions
4(2)
1.2.2 Challenges
6(1)
1.2.3 Ethics
6(1)
1.2.4 Education
7(1)
1.3 Fundamentals of biomaterials science
7(8)
1.3.1 Biomaterials and orthopedics
9(2)
1.3.2 Hydrogels as biomaterials
11(1)
1.3.3 Infectious disease control and biomaterials
12(1)
1.3.4 Biomaterials for neurological disorders and neuroregeneration
12(1)
1.3.5 Biomaterials for cancer
12(1)
1.3.6 Biomaterials and teeth
13(1)
1.3.7 Nanotechnology and picotechnology as biomaterials
13(1)
1.3.8 Biomaterials as sensors
14(1)
1.3.9 Biomaterials for drug delivery
14(1)
1.3.10 Biomaterials and 3D printing
14(1)
1.3.11 Biomaterials and stem cells
14(1)
1.4 The role of biomaterials in translational medicine
15(1)
References
16(7)
2 Regulatory aspects of medical devices and biomaterials
23(14)
Prabaha Sikder
Sarit B. Bhaduri
2.1 Introduction
23(1)
2.2 Terminology
24(2)
2.3 Basic pathways to medical device approval
26(6)
2.3.1 Premarketing notification: the 510(k) application
27(2)
2.3.2 Premarket approval
29(2)
2.3.3 The humanitarian device exemption
31(1)
2.4 Comparison and contrasts between the various pathways
32(1)
2.5 Postapproval follow-up for devices
33(1)
2.6 Comparison with EU approval protocols of devices
34(1)
2.7 Summary
35(1)
References
35(2)
3 The translatory aspects of calcium phosphates for orthopedic applications
37(20)
Huan Zhou
Sarit B. Bhaduri
3.1 Brief introduction of calcium phosphates
37(2)
3.2 Orthopedic implant coating
39(3)
3.2.1 The translatory aspects of calcium phosphate orthopedic coatings
39(1)
3.2.2 Porosity and roughness
40(1)
3.2.3 Adhesion strength
40(1)
3.2.4 Crystallinity
41(1)
3.2.5 Surface chemistry
41(1)
3.3 Synthetic bone grafts
42(5)
3.3.1 The translatory aspects of calcium phosphate bone grafts
42(1)
3.3.2 Porosity and interconnectivity
43(3)
3.3.3 Phase composition
46(1)
3.3.4 Mechanical strength
47(1)
3.4 New trends
47(2)
3.4.1 Carriers for active agents
47(2)
3.4.2 Three-dimensional-printing
49(1)
3.5 Conclusion
49(1)
References
50(7)
4 Cardiovascular engineering materials in translational medicine
57(36)
Weihua Song
Bae Hoon Lee
Lay Poh Tan
Huaqiong Li
4.1 Introduction
57(1)
4.2 The replacement of cardiovascular system using engineered biomaterials
58(5)
4.2.1 Valves
58(2)
4.2.2 Vascular grafts
60(3)
4.3 Injectable materials and their applications for cardiac repair and regeneration
63(10)
4.3.1 Injectable hydrogels
65(1)
4.3.2 Natural materials
66(5)
4.3.3 Synthetic materials
71(1)
4.3.4 Hybrid materials
72(1)
4.4 Discussion and concluding remarks
73(1)
References
74(19)
5 Delivery systems for biomedical applications: Basic introduction, research frontiers and clinical translations
93(24)
Changlu Xu
Varun Sivarajan Thiruvadi
Rachel Whitmore
Huinan Liu
5.1 Introduction
93(6)
5.1.1 Overview of delivery systems
93(6)
5.2 Biological cargos utilized in delivery systems
99(1)
5.2.1 Types of biological cargos
99(1)
5.2.2 Approaches and mechanisms of cargo loading
99(1)
5.3 Mechanism for cargo delivery
100(5)
5.3.1 Passive delivery
100(1)
5.3.2 Active delivery
101(4)
5.4 Research frontiers of delivery systems
105(2)
5.4.1 Development trends of delivery systems
105(1)
5.4.2 Current emphasis of delivery systems
106(1)
5.5 Clinical translation of delivery systems
107(3)
5.5.1 Oral delivery systems
107(2)
5.5.2 Nanoparticles and liposomes
109(1)
5.5.3 3D scaffolds and implants
109(1)
5.6 Conclusions
110(1)
References
111(6)
6 Biomaterials and scaffolds for the treatment of spinal cord injury
117(24)
Xiaoxiao Wen
Saijilafu
Zongping Luo
Huilin Yang
Weihua Wang
Lei Yang
6.1 Introduction
117(1)
6.2 Electrospun scaffolds
118(4)
6.2.1 Electrospun scaffolds with aligned structures
118(3)
6.2.2 Establishing 3D fibrous guidance channels
121(1)
6.2.3 Incorporation of bioactive components
122(1)
6.3 Self-assembling peptide scaffolds
122(5)
6.4 Scaffolds based on carbon nanomaterials
127(4)
6.4.1 Carbon nanotubes
127(2)
6.4.2 Graphene
129(2)
6.5 Scaffolds combined with nanoparticles
131(2)
6.6 Summary
133(1)
References
134(7)
7 MoS2-based biomaterials for cancer therapy
141(22)
Xiaocheng Wang
Jiang Chang
Chengtie Wu
7.1 Introduction
141(1)
7.2 MoS2-based nanomaterials for PTT
142(6)
7.2.1 Basic properties and synthesis of MoS2 nanomaterials
142(1)
7.2.2 MoS2 nanoparticles for photothermal monotherapy
143(2)
7.2.3 MoS2-based nanomaterials for photothermal combination therapy
145(3)
7.3 MoS2-based biomaterials for tumor therapy and tissue regeneration
148(7)
7.3.1 Conceptual background on integrating tumor therapy with tissue engineering
148(1)
7.3.2 Preparation of MoS2-based bioceramic scaffolds
149(1)
7.3.3 Functional evaluation of MoS2-based scaffolds
150(5)
7.4 Conclusions and perspectives
155(1)
Acknowledgments
156(1)
References
156(7)
8 Surface modification of medical devices at nanoscale---recent development and translational perspectives
163(28)
Kate E. Fox
Nhiem L. Tran
Tuan A. Nguyen
Thuat T. Nguyen
Phong A. Tran
8.1 Coating as a surface additive modification approach
164(6)
8.1.1 Nanostructured coatings with antibacterial properties
165(1)
8.1.2 Nanostructured coatings with antiinflammation properties
166(1)
8.1.3 Nanostructured coating in preventing thrombosis and restenosis
167(1)
8.1.4 Key coating techniques that have high translation potential
168(2)
8.2 Surface subtractive modification approaches
170(3)
8.2.1 Blasting
170(1)
8.2.2 Acid etching
171(1)
8.2.3 Anodization
172(1)
8.3 Nanofabrication---recent development originated from microelectronic industry for medical device applications
173(5)
8.3.1 Fabrication techniques
175(2)
8.3.2 Some important applications of micro- and nanofabrication in medical devices
177(1)
8.4 Translation and perspectives
178(2)
8.5 Concluding remarks and future directions
180(1)
References
181(10)
9 Nanotechnology and picotechnology: A new arena for translational medicine
191(22)
Ebrahim Mostafavi
Pooneh Soltantabar
Thomas J. Webster
9.1 Introduction
191(1)
9.2 Definition of nanotechnology
192(2)
9.3 Nanomaterials and synthesis approaches
194(2)
9.3.1 Bottom-up
196(1)
9.3.2 Top-down
196(1)
9.4 Definition of regenerative medicine
196(1)
9.5 Nanotechnology in regenerative medicine
197(10)
9.5.1 Nanotechnology in wound dressings (skin regeneration)
204(1)
9.5.2 Nanotechnology in cardiac tissue regeneration
205(1)
9.5.3 Nanotechnology in bone regeneration (cartilage, orthopedics, and periodontal)
206(1)
9.6 Concerns of using nanotechnology in medicine: nanotoxicity
207(1)
9.7 Definition and promises of picotechnology
208(2)
References
210(3)
10 Advanced biomaterials for biosensor and theranostics
213(44)
Haoran Liu
Jun Ge
Eugene Ma
Lei Yang
10.1 Introduction to biosensors and theranostics
213(3)
10.1.1 Definition and classification of biosensors
213(3)
10.1.2 Theranostics: concept and purposes
216(1)
10.2 Advanced biomaterials for biosensors
216(15)
10.2.1 Carbon-based nanomaterials
216(6)
10.2.2 Conductive polymers
222(2)
10.2.3 Quantum dots-based biosensor
224(7)
10.3 Novel materials for theranostics
231(12)
10.3.1 Constitution of theranostic systems
231(1)
10.3.2 Novel materials for carriers in theranostic systems
232(5)
10.3.3 Imaging or sensing agents
237(3)
10.3.4 Therapeutic agents
240(3)
10.3.5 Translational status
243(1)
10.4 Summary and outlook
243(1)
References
244(13)
11 Biomedical applications and biomaterial delivery strategies of growth factors
257(12)
Shuge Sun
Anne Yau
Yupeng Chen
11.1 Introduction
257(1)
11.2 Growth factors for the treatment of wound healing
258(1)
11.3 Growth factors for the treatment of Traumatic Brain Injury (TBI)
258(1)
11.4 Growth factors for the treatment of Rheumatoid Arthritis (RA)
259(1)
11.5 Growth factor for the treatment of cancer
260(1)
11.6 Materials for growth factor delivery
260(1)
11.7 Polymers
261(1)
11.8 Hydrogel
261(1)
11.9 Inorganic materials
262(1)
11.10 Other bio-inspired materials
262(1)
11.11 Conclusion
263(1)
References
264(5)
12 3D printing in the research and development of medical devices
269(22)
Huan Zhou
Sarit B. Bhaduri
12.1 Introduction
269(1)
12.2 Brief overview of 3D printing
270(5)
12.3 Regulation guidance of 3D printing in medical devices
275(1)
12.4 FDA approved applications of 3D printed medical devices
276(6)
12.5 Bioprinting
282(1)
12.6 4D printing
283(1)
12.7 Conclusions
284(1)
References
284(7)
13 Adipose tissue regeneration: Scaffold---Biomaterial strategies and translational perspectives
291(31)
Mina Mohseni
Nathan J. Castro
Hoang Phuc Dang
Tan Dat Nguyen
Hieu Minh Ho
Minh Phuong Nam Tran
Thi Hiep Nguyen
Phong A. Tran
13.1 Introduction
291(1)
13.2 Scaffold fabrication methods
292(1)
13.3 Adipose tissue-engineered scaffolds
293(10)
13.3.1 Natural scaffolds
295(4)
13.3.2 Synthetic scaffolds
299(4)
13.4 Regeneration strategy---growth factor delivery
303(5)
13.4.1 Natural polymers as delivery vehicle
304(3)
13.4.2 Synthetic polymers as delivery vehicle
307(1)
13.5 Regeneration strategy: stem cells/tissue/fat delivery
308(2)
13.5.1 Stem cell delivery
308(1)
13.5.2 Tissue delivery
309(1)
13.6 Regeneration strategies: antimicrobial properties
310(4)
13.7 Anticancer drug delivery for breast cancer
314(1)
13.8 Translation perspective and future outlook
315(7)
References 322(9)
Index 331
Professor, Orthopaedic Institute and the Department of Orthopaedics, the First Affiliated Hospital, Soochow University, China Thomas J. Webster is a Professor at the School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, China. He is also a Visiting Professor at the Center for Biomaterials, Vellore Institute of Technology, Vellore, India and the Department of Materials Science and Engineering, Federal University of Piaui, Brazil. His degrees are in chemical engineering from the University of Pittsburgh (B.S., 1995) and in biomedical engineering from Rensselaer Polytechnic Institute (M.S., 1997; Ph.D., 2000). He has served as a professor at Purdue University (2000-2005), Brown University (2005-2012), and Northeastern University (2012-2021). He was the founding editor-in-chief of the International Journal of Nanomedicine (pioneering the open-access format). Prof. Webster has received numerous honors including: 2012, Fellow, American Institute for Medical and Biological Engineering; 2013, Fellow, Biomedical Engineering Society; 2016, International College of Fellows, Biomaterials Science and Engineering; 2016, Acta Biomaterialia Silver Award; 2019, Overseas Fellow, Royal Society of Medicine (UK); and 2022, Clarivate Most Distinguished Researcher (Top 0.1% in citations). He also served as the President of the U.S. Society For Biomaterials.
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