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E-book: Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues

Edited by (Professor of Computational Bioengineering, University of Leeds, UK)
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Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System reviews how a wide range of materials are modelled and how this modelling is applied. Computational modelling is increasingly important in the design and manufacture of biomedical materials, as it makes it possible to predict certain implant-tissue reactions, degradation, and wear, and allows more accurate tailoring of materials' properties for the in vivo environment.

Part I introduces generic modelling of biomechanics and biotribology with a chapter on the fundamentals of computational modelling of biomechanics in the musculoskeletal system, and a further chapter on finite element modelling in the musculoskeletal system. Chapters in Part II focus on computational modelling of musculoskeletal cells and tissues, including cell mechanics, soft tissues and ligaments, muscle biomechanics, articular cartilage, bone and bone remodelling, and fracture processes in bones. Part III highlights computational modelling of orthopedic biomaterials and interfaces, including fatigue of bone cement, fracture processes in orthopedic implants, and cementless cup fixation in total hip arthroplasty (THA). Finally, chapters in Part IV discuss applications of computational modelling for joint replacements and tissue scaffolds, specifically hip implants, knee implants, and spinal implants; and computer aided design and finite element modelling of bone tissue scaffolds.

This book is a comprehensive resource for professionals in the biomedical market, materials scientists and mechanical engineers, and those in academia.

  • Covers generic modelling of cells and tissues; modelling of biomaterials and interfaces; biomechanics and biotribology
  • Discusses applications of modelling for joint replacements and applications of computational modelling in tissue engineering

More info

A complete guide to computational modelling for bioengineers, covering joint replacement, bone tissue scaffolds, and more
Contributor contact details xi
Woodhead Publishing Series in Biomaterials xv
Foreword xxi
Preface xxiii
Part I Generic modelling of biomechanics and biotribology 1(90)
1 Fundamentals of computational modelling of biomechanics in the musculoskeletal system
3(9)
Z. Jin
1.1 Computational approach and its importance
3(4)
1.2 Generic computational approach and important considerations
7(1)
1.3 Computational methods and software
8(1)
1.4 Future trends
8(1)
1.5 Sources of further information and advice
9(1)
1.6 References
10(2)
2 Finite element modeling in the musculoskeletal system: generic overview
12(27)
L. Ren
Z. Qian
2.1 The musculoskeletal (MSK) system
12(2)
2.2 Overview of the finite element (FE) method
14(2)
2.3 State-of-the-art FE modeling of the MSK system
16(5)
2.4 Key modeling procedures and considerations
21(4)
2.5 Challenges and future trends
25(2)
2.6 References
27(12)
3 Joint wear simulation
39(52)
M. Strickland
M. Taylor
3.1 Introduction
39(1)
3.2 Classification of wear
40(1)
3.3 Analytic and theoretical modelling of wear
41(10)
3.4 Implementation of wear modelling in the assessment of joint replacement
51(13)
3.5 Validating wear models
64(5)
3.6 Future trends 66 3:7 References
69(7)
3.8 Appendix: useful tables
76(15)
Part II Computational modelling of musculoskeletal cells and tissues 91(212)
4 Computational modeling of cell mechanics
93(48)
M.L. Rodriguez
N.J. Sniadecki
4.1 Introduction
93(1)
4.2 Mechanobiology of cells
94(6)
4.3 Computational descriptions of whole-cell mechanics
100(1)
4.4 Liquid drop models
100(7)
4.5 Solid elastic models
107(2)
4.6 Power-law rheology model
109(2)
4.7 Biphasic model
111(2)
4.8 Tensegrity model
113(2)
4.9 Semi-flexible chain model
115(1)
4.10 Dipole polymerization model
116(2)
4.11 Brownian ratchet models
118(3)
4.12 Dynamic stochastic model
121(1)
4.13 Constrained mixture model
122(3)
4.14 Bio-chemo-mechanical model
125(3)
4.15 Computational models for muscle cells
128(2)
4.16 Future trends
130(2)
4.17 References
132(9)
5 Computational modeling of soft tissues and ligaments
141(32)
M. Marino
G. Vairo
5.1 Introduction
141(1)
5.2 Background and preparatory results
142(4)
5.3 Multiscale modeling of unidirectional soft tissues
146(12)
5.4 Multiscale modeling of multidirectional soft tissues
158(6)
5.5 Mechanics at cellular scale: a submodeling approach
164(2)
5.6 Limitations and conclusions
166(2)
5.7 Acknowledgments
168(1)
5.8 References
169(4)
6 Computational modeling of muscle biomechanics
173(32)
T. Siebert
C. Rode
6.1 Introduction
173(2)
6.2 Mechanisms of muscle contraction: muscle structure and force production
175(2)
6.3 Biophysical aspects of skeletal muscle contraction
177(7)
6.4 One-dimensional skeletal muscle modeling
184(4)
6.5 Causes and models of history-dependence of muscle force production
188(3)
6.6 Three-dimensional skeletal muscle modeling
191(4)
6.7 References
195(10)
7 Computational modelling of articular cartilage
205(39)
L.P. Li
S. Ahsanizadeh
7.1 Introduction
205(6)
7.2 Current state in modelling of articular cartilage
211(9)
7.3 Comparison and discussion of major theories
220(8)
7.4 Applications and challenges
228(5)
7.5 Conclusion
233(1)
7.6 References
234(10)
8 Computational modeling of bone and bone remodeling
244(24)
H. Gong
L. Wang
M. Zhang
Y. Fan
8.1 Introduction
244(1)
8.2 Computational modeling examples of bone mechanical properties and bone remodeling
245(12)
8.3 Results of computational modeling examples
257(3)
8.4 Conclusion and future trends
260(5)
8.5 Sources of further information and advice
265(1)
8.6 Acknowledgments
265(1)
8.7 References
265(3)
9 Modelling fracture processes in bones
268(35)
A. Abdel-Wahab
S. Li
V.V. Silberschmidt
9.1 Introduction
268(1)
9.2 A brief update on the literature
269(4)
9.3 Physical formulation and modelling methods
273(12)
9.4 Results and discussion
285(13)
9.5 Challenges, applications and future trends
298(1)
9.6 Sources of further information and advice
299(1)
9.7 Acknowledgement
299(1)
9.8 References
300(3)
Part III Computational modelling of orthopaedic biomaterials and interfaces 303(84)
10 Modelling fatigue of bone cement
305(26)
A.B. Lennon
10.1 Introduction
305(3)
10.2 Modelling fatigue of bulk cement
308(7)
10.3 Cement-implant interface
315(1)
10.4 Cement-bone interface
316(1)
10.5 Current and future trends
317(7)
10.6 Conclusion
324(1)
10.7 References
324(7)
11 Modelling fracture processes in orthopaedic implants
331(38)
S. Stacj
11.1 Introduction
331(1)
11.2 The fracture mechanics approach
332(2)
11.3 Mechanical properties
334(8)
11.4 Determination of fracture mechanics parameters
342(8)
11.5 Overview of computer methods used in mechanics
350(7)
11.6 Simulation and modelling of the crack path in biomaterials
357(8)
11.7 Challenges and future trends
365(1)
11.8 References
366(3)
12 Modelling cementless cup fixation in total hip arthroplasty (THA)
369(18)
C. Schulze
C. Zietz
R. Souffrant
R. Bader
D. Kluess
12.1 Cup fixation in acetabular bone stock
369(2)
12.2 Measurement and numerical analysis of cup fixation
371(2)
12.3 Summary of the relevant literature
373(1)
12.4 Materials and assumptions
374(4)
12.5 Modelling methods and details
378(4)
12.6 Understanding and interpretation
382(1)
12.7 Challenges, applications and future trends
383(1)
12.8 References
384(3)
Part IV Applications of computational modelling for joint replacements and tissue scaffolds 387(126)
13 Computational modeling of hip implants
389(28)
J. Geringer
L. Imbert
K. Kim
13.1 Introduction
389(2)
13.2 Modeling and methods
391(5)
13.3 Results
396(10)
13.4 Discussion
406(5)
13.5 Future trends
411(1)
13.6 Conclusion
412(1)
13.7 References
413(4)
14 Computational modelling of knee implants
417(30)
J.H. Muller
14.1 Introduction
417(7)
14.2 Application of computational models in analysis of knee implants
424(2)
14.3 Assumptions for kinematics and kinetics
426(2)
14.4 Model definition
428(4)
14.5 Model formulation
432(3)
14.6 Model solution
435(3)
14.7 Model validation
438(4)
14.8 Conclusion, challenges and future trends
442(1)
14.9 Sources of further information and advice
443(1)
14.10 References
443(4)
15 Computational modelling of spinal implants
447(38)
J. Noailly
A. Malandrino
F. Galbusera
15.1 Introduction
447(2)
15.2 Spine and implant computational biomechanics
449(9)
15.3 Numerical assessments of spinal implants
458(9)
15.4 Future trends
467(6)
15.5 Conclusion
473(1)
15.6 References
474(11)
16 Finite element modelling of bone tissue scaffolds
485(28)
A. Boccaccio
A. Messina
C. Pappalettere
M. Scaraggi
16.1 Introduction
485(5)
16.2 Fundamentals of computational mechanobiology
490(6)
16.3 Applications of finite element modelling (FEM) and computational mechanobiology to bone tissue engineering
496(8)
16.4 Discussion
504(3)
16.5 Conclusions and future trends
507(1)
16.6 References
507(6)
Index 513
Prof. Jin is Professor of Computational Bioengineering at the Institute of Medical and Biological Engineering, and Visiting Honorary Professor for Mechanical Engineering, University of Leeds, UK. His research interests are joint replacement and substitution, tissue re-engineering, and functional spinal interventions, focusing on improving function using structural biomaterials.
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