This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well more experienced investigators.
1. Introduction to the complexity of cell surface and tissue matrix
glycoconjugates..-
2. Introduction to cells comprising the nervous system..-
3. Synthesis.- processing.- and function of N-glycans in N-glycoproteins..-
4. Synthesis of O-linked glycoconjugates in the nervous system..- 5.
Chemistry and function of glycosaminoglycans in the nervous system..- 6. Use
of glycan-targeted antibodies/lectins to study the expression/function of
glycosyltransferases in the nervous system..- 7. Capillary electrophoresis
and mass spectrometry-based glycosylation analysis in glycomics and
glycoproteomics..- 8. Structural analysis of oligosaccharides and
glycoconjugates using NMR..- 9. Glycolipid and glycoprotein expression
during neural development..-
10. Gangliosides and cell surface ganglioside
glycohydrolases in the nervous system (request them to include gal-cer and
sulfatide)..-
11. Role of myelin-associated glycoproteins in the peripheral
nervous system..-
12. Glycosignaling: a general review..-
13.
Glycosphingolipids in the regulation of the nervous system..-
14.
O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in
neurodegeneration..- 15. Glycoconjugates in nuclear membranes..-
16.
N-glycosylation in regulation of the nervous system..-
17. Role of
carbohydrates in the interaction of pathogens with neural cells..-
18.
Glycoconjugate changes in aging and age-related diseases..-
19. Gangliosides
and glycolipids in neurodegenerative disorders..-
20. Inborn errors of
glycosphingolipid catabolism and potential treatment..-
21. Neurological
aspects of human glycosylation disorders..-
22. Glycoconjugates and neural
tumors..-
23. Galectins and neuroinflammation ..-
24. Glycoconjugates and
neuroimmunological diseases..-
25. Targeting nanoparticle drug carriers to
the brain..-
26. Use of quantum dots to treat inherited lysosomal storage
diseases..- 27. MALDI-FTICR MS imaging of nervous system glycoconjugates.
Cara-Lynne Schengrund, PhD, is Professor Emeritus, Department of Biochemistry and Molecular Biology, Penn State University, Hershey, Pennsylvania
Robert K. Yu, PhD, Med ScD, was Professor, Department of Neuroscience and Regenerative Medicine, and GRA Eminent Scholar in Molecular and Cellular Neurobiology, Medical College of Georgia at Augusta University, Augusta, Georgia
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