Covers chemical, biological, medical, and industrial aspects of synthetic antioxidants. Contains sections on general concepts, synthetic derivatives of natural antioxidants, phenolic antioxidants, 21-aminosteroids or lazaroids, sulfhydryl- and selenium-containing, nitrones and nitroxides, SOD mimics, and metal chelators, surveying physicochemical properties of compounds and their applications in clinical medicine and the food industry. Of interest to pharmacologists, physiologists, biochemists, and cell biologists. Annotation c. by Book News, Inc., Portland, Or.
Emphasizes the efficacy of synthetically occurring compounds in the management of free radical-mediated illnesses. The text details the design, development and delivery of therapeutic antioxidants used in the treatment of pathophysiological disorders, from amylotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) to Alzheimer's disease.
Series Introduction iii(4) Lester Packer Jurgen Fuchs Preface vii(6) Contributors xiii Part I General Concepts 1(52)
1. Approaches and Rationale for the Design of Synthetic Antioxidants as Therapeutic Agents 1(52) Craig E. Thomas Part II Synthetic Derivatives of Natural Antioxidants 53(124)
2. Design and Biological Evaluation of Tissue-Directed a-Tocopherol Analogs 53(42) Margaret A. Petty Frank N. Bolkenius James Dow Gilbert Marciniak
3. Physical and Chemical Mechanisms of the Antioxidant Action of Tirilazad Mesylate 95(44) Dennis E. Epps John M. McCall
4. Anionic Tocopherol Esters as Antioxidants and Cytoprotectants 139(38) Marc W. Fariss Part III Phenolic Antioxidants 177(84)
5. Phenolic Antioxidants: Physiological and Toxicological Aspects 177(48) Regine Kahl
6. Antioxidant Properties of Probucol 225(16) Etsuo Niki Noriko Noguchi
7. Antioxidant Properties of the Catechol Derivative Nitecapone 241(20) Nobuya Haramaki Lucia Marcocci Teruyuki Kawabata Lester Packer Part IV 21-Aminosteroids or Lazaroids 261(24)
8. Neuroprotective Efficacy and Mechanisms of the Lazaroids 261(24) Edward D. Hall Part V Sulfhydryl- and Selenium-Containing Compounds 285(54)
9. Antioxidant Properties of Ebselen 285(20) Noriko Noguchi Etsuo Niki
10. The Development of Diaryl Chalcogenides and a-(Phenylselenenyl) Ketones with Antioxidant and Glutathione Peroxidase-Mimetic Properties 305(16) Ian A. Cotgreave Lars Engman
11. Modulation of Glutathione 321(18) Mary E. Anderson Part VI Nitrones and Nitroxides 339(36)
12. Nitrone Radical Traps as Protectors of Oxidative Damage in the Central Nervous System 339(12) Robert A. Floyd Guang-Jun Liu Peter K. Wong
13. Antioxidant Properties of Nitroxides and Nitroxide SOD Mimics 351(24) Amram Samuni Murali C. Krishna Part VII SOD Mimics 375(34)
14. Mimics of Superoxide Dismutase 375(34) Kevin M. Faulkner Irwin Fridovich Part VIII Metal Chelators 409(28)
15. Antioxidant Properties of Synthetic Iron Chelators 409(28) Clifford S. Collis Catherine A. Rice-Evans Index 437
LESTER PACKER is Professor of Molecular and Cell Biology, Division of Cell and Developmental Biology, University of California, Berkeley. Dr. Packer is the author of over 500 published articles and coeditor of the Handbook of Antioxidants, Oxidative Stress in Dermatology, Vitamin E in Health and Disease, Retinoids: Progress in Research and Clinical Applications, and Biothiols in Health and Disease (all tides, Marcel Dekker, Ine.). He is President of the Oxygen Club of California, President of the International Society of Free Radical Research, and a member of the Oxygen Society, the American Society of Biochemistry and Molecular Biology, and the American Institute of Nutrition, among others. Dr. Packer received the B.S. (1951) and M.S. (1952) degrees in biologyand chemistry from Brooklyn College, Brooklyn, New York, and the Ph.D. degree (1956) in microbiology and biochemistry from Yale University, New Haven, Connecticut., ENRIQUE CADENAS is a Professor in and Chairman of the Department of Molecular Pharmaeology and Toxicology in the School of Pharmacy and a Professor of Biochemistry in the School of Medicine, University of Southern California, Los Angeles. The author of over 160 professionai publications and coeditor of the Handbook of Antioxidants and Biothiols in Health and Disease (both titles, Marcel Dekker, Inc.), Dr. Cadenas is a member of the American Chemical Society, the American Society of Photobiology, the Biochemical Society (United Kingdom), and the European Society for Photobiology, among others. Dr. Cadenas received the M.D. degree (1973) and the Ph.D. degree (1977) in biochemistry from the University of Buenos Aires School of Medicine, Argentina.
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