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1 Introduction 2 A Review of Third-Variable Effect Inferences 3 Advanced Statistical Modeling and Machine Learning Methods Used in the Book 4 The General Third-Variable Effect Analysis Method 5 The Implementation of General Third-Variable Effect Analysis Method 6 Assumptions for the General Third-Variable Analysis 7 Multiple Exposures and Multivariate Responses 8 Regularized Third-Variable Effect Analysis for High-Dimensional Dataset 9 Interaction/Moderation Analysis with Third-Variable Effects 10 Third-Variable Effect Analysis with Multilevel Additive Models 11 Bayesian Third-Variable Effect Analysis 12 Other Issues