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E-raamat: 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part A

Volume editor (University of Malta, Malta), Volume editor (Centre National de la Recherche Scientifique, France)
  • Formaat: PDF+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 02-Feb-2021
  • Kirjastus: Elsevier Science Publishing Co Inc
  • Keel: eng
  • ISBN-13: 9780128245682
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5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part ASuurem pilt
  • Formaat: PDF+DRM
  • Sari: Progress in Brain Research
  • Ilmumisaeg: 02-Feb-2021
  • Kirjastus: Elsevier Science Publishing Co Inc
  • Keel: eng
  • ISBN-13: 9780128245682
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5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance, Part B, Volume 260 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Serotonin-noradrenalin interactions, Electrophysiological and neurochemical evidence for an interaction of serotonin on noradrenergic neurons, Serotonin and cannabinoid system, 5-HT/CB interaction in the CNS in health and disease, Serotonin2A receptors and Cannabinoids, CB1/5-HT/GABA in food intake, A close interaction between serotonergic system and BDNF in the mechanism of action of antidepressant, 5-HT/ Ach, Interaction of 5-HT2A/2C ligands and nicotine, and more.
  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Progress in Brain Research series
  • Includes the latest information on the 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance, Part B
Dedication v
Contributors vii
Chapter 1 5-HT interaction with other neurotransmitters: An overview
1(6)
Philippe De Deurwaerdere
Giuseppe Di Giovanni
Chapter 2 Role of central serotonin and noradrenaline interactions in the antidepressants' action: Electrophysiological and neurochemical evidence
7(76)
Sarah Delcourte
Adeline Etievant
Nasser Haddjeri
1 Introduction
8(1)
2 Morpho-physiological aspects of serotonin system
9(7)
2.1 5-HT neurons
9(3)
2.2 Modulation of 5-HT release
12(4)
3 Morpho-physiological aspects of noradrenergic system
16(3)
3.1 Noradrenergic neurons
16(1)
3.2 Modulation of NA release
17(2)
4 Inter-modulations of noradrenaline and serotonin systems
19(6)
4.1 Interactions at somatodendritic level
20(2)
4.2 Interactions at terminal level
22(3)
5 Effects of antidepressant drugs on noradrenaline and serotonin systems
25(11)
5.1 Effects on NA system
25(7)
5.2 Selective 5-HT and NA reuptake inhibitors
32(4)
6 Other candidates
36(6)
6.1 "Non-5-HT/NA" antidepressants
37(1)
6.2 Multimodal antidepressant
38(1)
6.3 Combinatory therapeutic strategies
38(2)
6.4 Non-pharmacological antidepressants
40(2)
7 Concluding remarks
42(1)
Funding
43(1)
References
43(40)
Chapter 3 Endocannabinoid-serotonin systems interaction in health and disease
83(52)
Roberto Colangeli
G. Campbell Teskey
Giuseppe Di Giovanni
1 The endocannabinoid system
84(5)
1.1 Historical background
84(1)
1.2 The eCB system
85(1)
1.3 Endogenous cannabinoids
85(2)
1.4 Synthetic cannabinoids
87(1)
1.5 Physiology of the eCB system
88(1)
2 eCB and 5-HT systems
89(8)
2.1 Influence of the eCB system on 5-HT transmission
89(2)
2.2 eCB signaling influences 5-HT release
91(2)
2.3 Interaction of (endo)cannabinoids with 5-HT receptor subtypes
93(3)
2.4 Influence of 5-HT signaling on eCB system
96(1)
3 Cannabinoid/serotonin interaction in psychiatric disorders
97(14)
3.1 Depression
97(3)
3.2 Anxiety
100(3)
3.3 Psychosis
103(3)
3.4 Epilepsy
106(5)
4 Conclusions
111(1)
Acknowledgments
111(1)
References
111(24)
Chapter 4 Serotonin 2A receptors and cannabinoids
135(42)
Ines Ibarra-Lecue
Rebeca Diez-Alarcia
Leyre Uriguen
1 Introduction
135(2)
2 5-HT2ARS
137(5)
2.1 General aspects
137(1)
2.2 5-HT2ARs in the brain
137(1)
2.3 5-HT2AR intracellular signaling
138(2)
2.4 5-HT2AR in mental disorders
140(2)
3 Cannabinoids
142(3)
3.1 Pharmacology of cannabinoid compounds
142(1)
3.2 Endocannabinoid system
143(2)
3.3 Endocannabinoid system in mental disorders
145(1)
4 5-HT2AR and cannabinoids interaction
145(3)
4.1 5-HT2AR/CB1R heterocomplex
147(1)
5 5-HT2AR and cannabinoids interaction in mental disorders
148(8)
5.1 Schizophrenia
148(5)
5.2 Depression and anxiety
153(2)
5.3 Cognitive processes
155(1)
5.4 5-HT2AR and cannabinoids interaction in pain
155(1)
6 Conclusions
156(1)
References
157(20)
Chapter 5 CB1/5-HT/GABA interactions and food intake regulation
177(20)
Rodrigo Erick Escartm Perez
Juan Manuel Mancilla Diaz
Felipe Cortes Salazar
Veronica Elsa Lopez Alonso
Benjamin Floran Garduno
1 Introduction
177(1)
2 Interaction between cannabinoid 1 receptors and serotonin
178(4)
3 Interactions between GAB A and serotonin
182(3)
4 Implications of 5-HT/GABA/CB1 in pathological eating behavior
185(3)
5 Conclusion
188(1)
Acknowledgment
188(1)
References
188(9)
Chapter 6 Serotonergic neurons in the treatment of mood disorders: The dialogue with astrocytes
197(32)
Mathieu Charveriat
Bruno P. Guiard
1 Organization of the serotonergic system and role in the regulation of mood
198(4)
1.1 Developmental and functional diversity of 5-HT neuron
198(1)
1.2 A high heterogeneity of serotonergic receptors in neurons
199(1)
1.3 Expression of 5-HT receptors by astrocytes
200(1)
1.4 5-HT, a neurotransmitter involved in the regulation of mood
201(1)
2 Overview of the role of astrocytes in mood disorders
202(4)
2.1 Modification of astrocyte morphology and density during MD and antidepressant treatment
203(1)
2.2 MD-induced transcriptomic and proteomic alterations in astrocytes
203(3)
2.3 Astrocytes control neurogenesis, a key process in mood disorders and the therapeutic activity of antidepressant drugs
206(1)
3 A tight control of mood and serotonergic system by the main gliotransmitters
206(4)
3.1 Regulation of serotonergic pathways by neuronal and astrocyte glutamate
206(1)
3.2 D-Serine, a gliotransmitter with conflicting roles in MD
207(1)
3.3 Complex roles of ATP and adenosine
208(2)
4 Role of astrocyte neurotrophic factors in mood control and 5-HT pathways
210(4)
4.1 BDNF
210(3)
4.2 S100P
213(1)
4.3 GDNF
213(1)
5 Conclusion
214(1)
Acknowledgments
214(1)
References
214(15)
Chapter 7 5-HT2A and 5-HT2C receptors as potential targets for the treatment of nicotine use and dependence
229(36)
Guy A. Higgins
Edward M. Sellers
1 Introduction
230(1)
2 Behavioral and biological features of nicotine use and dependence
231(7)
2.1 Behavioral factors
231(3)
2.2 Biological factors
234(1)
2.3 Current treatments for nicotine dependence
235(3)
3 5-HT systems and the treatment of nicotine use and dependence
238(12)
3.1 Selective serotonin reuptake inhibitors (SSRIs)
238(1)
3.2 5-HT2A receptor approach
239(6)
3.3 5-HT2C receptor approach
245(5)
4 Summary and conclusions
250(1)
References
251(14)
Chapter 8 5-HT/GABA interaction in epilepsy
265(22)
Gabriele Deidda
Vincenzo Crunelli
Giuseppe Di Giovanni
1 Introduction
265(1)
2 Opposite role of GABA in epilepsy
266(1)
3 Role of serotonin in epilepsy
266(1)
4 Pathophysiology of temporal lobe epilepsy
267(1)
5 5-HT/GABA control of temporal lobe epilepsy and generalized seizures
267(4)
6 Pathophysiology of absence epilepsy and the role of GABA
271(1)
7 5-HT/GABA control of ASs
272(3)
7.1 5-HT receptors in the cortico-thalamic loop and modulation of GABA tonic current
273(2)
8 Concluding remarks
275(1)
Acknowledgments
276(1)
References
276(11)
Chapter 9 5-HT/GABA interaction in neurodevelopment and plasticity
287
Gabriele Deidda
Massimo Pierucci
Vincenzo Crunelli
Giuseppe Di Giovanni
1 Introduction
287(1)
2 The GABAergic system
288(4)
3 5-HT/GABA role in prenatal neurodevelopment
292(5)
3.1 5-HT/GABA interaction in the development of the spinal cord
292(2)
3.2 5-HT/GABA interaction in early cortical development
294(3)
4 5-HT/GABA role in postnatal development and critical period plasticity
297(10)
4.1 Postnatal development
297(2)
4.2 Critical period plasticity of somatosensory and visual systems
299(8)
5 5-HT role in adult neurogenesis
307(2)
6 5-HT and 5-HT/GABA role in adult plasticity
309(1)
7 Concluding remarks
309(1)
Acknowledgments
310(1)
References
310
Prof. Giuseppe Di Giovanni received his Ph.D. in Neuroscience from the University of Chieti, Italy and was a postdoctoral fellow at Yale University, USA. Previously Senior Lecturer of Human Physiology at the Faculty of Medicine and Surgery, University of Palermo, and Associate Professor at the University of Malta, from 2013 he is Professor of Human Physiology at the Medical School of the University of Malta and from 2018 Honorary Professor at Cardiff University, UK. His research focuses on understanding the pathophysiology of monoaminergic systems using electrophysiological and neurochemical approach. He has published more than 120 peer-reviewed papers, edited 7 books and 6 special issues of various journals. Professor Philippe De Deurwaerdère, Centre National de la Recherche Scientifique Bordeaux Cedex France
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