The pathological role of advanced glycation end products (AGEs) and of oxidative-carbonylic stress is well known in the context of diabetes. Moreover, there is also strong evidence that they play a pivotal role in the pathogenesis of some chronic disorders related to uremia, and namely to cardiovascular complications and dialysis-related amyloidosis. They may even play a crucial role in the loss of function of the peritoneal membrane in patients on peritoneal dialysis, a problem which limits the duration of such a treatment. Written by some of the most authoritative European experts, this publication includes up-to-date contributions on AGEs as related to diabetic nephropathy, hemodialysis and, particularly, peritoneal dialysis. The topics covered range from basic research (e.g. novel pathogenic pathways triggered by AGEs) to clinical issues, including substitutive therapy in uremic diabetic patients as well as original and new results from a clinical trial on peritoneal dialysis with a new bag. This publication will be of interest to nephrologists as well as those working in the field of diabetes or otherwise involved in AGE research, giving an idea into what direction research in this complex field is going and which will probably be the major clinical breakthroughs in the near future.
Introduction vii Chemistry and Pathobiology of Advanced Glycation End Products 1(9) Schleicher E.D. Bierhaus, A. Haring, H.-U. Nawroth, P.P. Lehmann, R. Age in Micro-and Macroangiopathy 10(12) Lapolla, A. Traldi, P. Fedele, D. Diabetic Nephropathy and Advanced Glycation End Products 22(11) Mene, P. Festuccia, F. Polci, R. Pugliese, F. Cinotti, G.A. Hemodialysis Techniques and Advanced Glycation End Products 33(7) Tessitore, N. Lapolla, A. Arico, N. Gammaro, L. Bernich, P. Fedele, D. (Padua) Diabetic Uraemia and Haemodialytic Treatments 40(11) Naso, A. Zagatti, R. Puma, G. Antonello, A. Romagnoli, G. Peritoneal Dialysis in Diabetic Patients 51(10) Bertoli, M. Bonfante, L. Gambaro, G. Cara, M. Virgilio, B. DAngelo, A. Molecular Biology of the Peritoneal Membrane: In Between Morphology and Function 61(13) Anglani, F. Forino, M. Del Prete, D. Ceol, M. Favaro, S. Peritoneal Transport in Long-Term Peritoneal Dialysis Patients and Its Relation with AGEs 74(8) Feriani, M. Exogenous Uptake of Carbonyl Stress Compounds Promoting AGE Formation from Peritoneal Dialysis Fluids 82(8) Wieslander, A. Linden, T. Musi, B. Jarkelid, L. Speidel, R. Beck, W. Henle, T. Deppisch, R. The Dialytic Failure of the Peritoneal Membrane 90(7) Lupo, A. Rugiu, C. Lapolla, A. Maiorca, P. Arico, C.N. Bernich, P. Brezzi, B. Maschio, G. A Peritoneal Dialysis Solution Prepared from a Three-Compartment Bag: Biological and Clinical Effects 97(10) Capelli, G. Amore, A. Bandiani, G. Cancarini, G. Coppo, R. Feriani, M. DellAquila, R. Saffioti, S. Spisni, C. Stingone, A. Orazi, E. Ballocchi, S. Renaux, J.L. Inhibition of Transforming Growth Factor-β1 Gene Overexpression as a Strategy to Prevent Fibrosis 107(7) Gambaro, G. Weigert, C. Ceol, M. Schleicher, E.D. Strategy for Preventing Peritoneal Dialysis Failure 114(11) Cancarini, G. Clinical Research in Peritoneal Dialysis 125(7) Coles, G.A. Contribution of the Mesangium to Elastic Strength and Anchorage of the Glomerular Capillary Tuft 132(10) Sterzel, R.B. Hartner, A. Hilgers, K.F. Bressan, G.M. Author Index 142(1) Subject Index 143
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