Advances in Genetics, Volume 107, provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Advances in Asthma Genetics: Filling persistent gaps, Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans, Genetic determinants of climate-resilience traits in millets, Founder variants and population genomes - towards precision medicine, and much more.
- Critically analyzes future directions for the study of clinical genetics
- Written and edited by recognized leaders in the field
- Presents new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics
| Contributors |
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ix | |
| Preface |
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xi | |
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1 Advances in asthma genetics |
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1 | (32) |
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1 | (1) |
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2 | (9) |
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11 | (4) |
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4 Asthma and the microbiome |
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15 | (7) |
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5 Pharmacogenomics of asthma |
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22 | (4) |
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6 Precision medicine in asthma |
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26 | (7) |
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27 | (6) |
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2 Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans |
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33 | (56) |
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1 Nutritional control of development in C. elegans---Why do we care? |
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34 | (1) |
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2 C. elegans postembryonic development |
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35 | (4) |
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3 Methods to measure developmental timing in C. elegans |
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39 | (3) |
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4 Nutrient sensing pathways in C. elegans |
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42 | (2) |
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5 Food deprivation provokes arrest at the L1 stage |
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44 | (29) |
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6 Larval arrest at other stages |
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73 | (2) |
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7 Diet-induced changes in developmental speed |
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75 | (14) |
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76 | (1) |
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76 | (13) |
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3 Diverse role of phytic acid in plants and approaches to develop low-phytate grains to enhance bioavailability of micronutrients |
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89 | (32) |
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Mehanathan Muthamilarasan |
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90 | (2) |
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2 Phytic acid structure, biosynthesis, and accumulation |
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92 | (4) |
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3 Diverse roles of phytic acid |
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96 | (3) |
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4 Antinutritional properties of phytic acid |
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99 | (2) |
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5 Conventional and molecular breeding for low phytic acid lines |
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101 | (5) |
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6 Transgene-based approaches to produce zero phytate grains |
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106 | (5) |
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111 | (10) |
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112 | (1) |
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112 | (9) |
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4 Founder variants and population genomes---Toward precision medicine |
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121 | (32) |
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122 | (2) |
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2 Resources cataloging founder variants |
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124 | (2) |
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3 Population databases of human genetic variants |
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126 | (2) |
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4 Approaches for detection of founder variants |
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128 | (1) |
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5 Founder variations and genetic diseases across the world |
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129 | (8) |
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6 Implications of founder mutations in public health |
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137 | (3) |
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7 Challenges and future directions |
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140 | (1) |
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141 | (12) |
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142 | (11) |
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5 Genomic perspectives on the circadian clock hypothesis of psychiatric disorders |
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153 | (40) |
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1 Introduction: Circadian clocks and their role in mental health and psychiatric disorders |
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154 | (8) |
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2 Phenotypic evidence for connections between circadian rhythms and psychiatric disorders |
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162 | (3) |
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3 Predictions of circadian clock genes as candidate genes for psychiatric disorders |
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165 | (2) |
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4 GWAS analysis of circadian phenotypes and psychiatric disorders, and the search for a connection |
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167 | (10) |
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177 | (16) |
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182 | (1) |
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182 | (11) |
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6 Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery |
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193 | (64) |
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194 | (3) |
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2 Chemistry of fungal SMs |
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197 | (27) |
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3 Drug discovery from fungi |
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224 | (15) |
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4 Genomics of fungal secondary metabolic clusters |
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239 | (18) |
| References |
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257 | |
Professor Kumar has considerable previous experience in writing and editing books and journals related to genetics and genomics. His books include Genomics and Clinical Medicine and Genomics and Health in the Developing World. He founded and leads the new open access journal Applied and Translational Genomics, published by Elsevier. He has published 40 articles in the journals literature. Professor Dhavendra Kumar is a Visiting Professor, Genomic Policy Unit, Faculty of Life Sciences and Education, The University of South Wales and Consultant in Clinical Genetics at the University Hospital of Wales, Institute of Medical Genetics, Cardiff University, Cardiff, United Kingdom. He is one of the Consultants for the All Wales Medical Genetics Service and the lead Clinician for Clinical Cardiovascular Genetics. After qualifying in Medicine from the King Georges Medical College, University of Lucknow, India, he completed postgraduate training in Pediatrics with an MD. Since 1980 he has pursued a career in Medical Genetics in the UK. In 1990 he became a Diplomate of the American Board of Medical Genetics. He is a Fellow of the American College of Medical Genetics (FACMG) and as well as Royal Colleges of Physicians (FRCP-London and FRCP-Ireland) and Pediatrics and Child Health (FRCPCH-UK).
In 2015, he was conferred with the higher degree of DSc by his Alma Mater, King Georges Medical University, Lucknow (UP, India) based on his life-time contributions and achievements to genetic and genomic applications in medicine and health.
Lisainfo e-raamatute kohta